DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG40470 and Trhde

DIOPT Version :9

Sequence 1:	NP_001036635.1	Gene:	CG40470 / 3355093	FlyBaseID:	FBgn0058470	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_666353.2	Gene:	Trhde / 237553	MGIID:	2384311	Length:	1066	Species:	Mus musculus

Alignment Length:	958	Identity:	222/958 - (23%)
Similarity:	393/958 - (41%)	Gaps:	155/958 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 SEVRLPKEVLPLSYEVLIEPHMDNQNFEGSIRMHLRWIGDSKKVYFHAHDTLLIDVSQINLTTLN 113
            :::||...:.||.|.:::...|:|..|.|.:.:.:.....::.|..||        |::.:..:.
Mouse   179 TQLRLSGHLKPLHYNLMLTAFMENFTFSGEVNVEIACRNATRYVVLHA--------SRVAVEKVQ 235

  Fly   114 MGDGTLDKNVIILRGVRLPRKPVFVLYLKDKIKKGSECLLDIYFQGNISETEEGLFRSYYTNSGN 178
            :.:......|.:......|:..|.|:.|...:.......|.|.:...|.....|.|||.|.   .
Mouse   236 VAEDRAFGAVPVAGFFLYPQTQVLVVVLNRTLDAQRHYNLKIIYNALIENELLGFFRSSYV---I 297

  Fly   179 DGEEIYL-ATNLKPNNARRLFPCFDEPGIKVPFNVSIARPKGYITLFNTPLHNTINHPKLRSYSL 242
            .||..:| .|...|.:||:.|||||||..|..|.:||.....|::|.|.|:..::....  .:..
Mouse   298 HGERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNMPVETSVFEED--GWVT 360

  Fly   243 DFFHTTAPMSTHAFGF---------------VILKLHMWNEHKIVKSSDIPAINIWSNNLSSTNL 292
            |.|..|..|||:...:               |:::|:. ....|.:.|...|::|      :..|
Mouse   361 DHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYA-RPDAIRRGSGDYALHI------TKRL 418

  Fly   293 LDIQNKLNVAHTTIQHFFNIPLPLTKLDVIAIPSLATLPFISAS--GILIARESEI-LKKDVFEI 354
            ::.          .:.:|.:|..|.|||::|:|.   .|:.:..  |:.|..|..| |...|..|
Mouse   419 IEF----------YEDYFKVPYSLPKLDLLAVPK---HPYAAMENWGLSIFVEQRILLDPSVSSI 470

  Fly   355 S----------RELIYQWIGIWITPEWWTDANVNKALISFIASEIVFEINGGIEFNGK---YP-- 404
            |          .|:.:||.|..:||.||.|..:.:....:            .||.|.   ||
Mouse   471 SYLLDVTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHY------------FEFVGTDYLYPAW 523

  Fly   405 ----MTILYSLYYE------LSKRYPNS----HITGIKHEF---ASIKVQLIIRMLSLTVGKYTF 452
                ...|..:.:|      |:..:|.|    ..|.|...|   |..|...:||||:..:|...|
Mouse   524 NMEKQRFLTDVLHEVMLLDGLASSHPVSQEVLRATDIDRVFDWIAYKKGAALIRMLANFMGHSVF 588

  Fly   453 RLGIQSFICDYKFKTYKSSDFWNAITTQAKADNSLDSDLSILSIAESWLEHSRLPLVTIIRDYDS 517
            :.|:|.::..:|:.....:|.||.::...:.:...   ::|..:.:.|......|::||:.:..:
Mouse   589 QRGLQDYLTIHKYGNAARNDLWNTLSEALRRNGKY---VNIQEVMDQWTLQMGYPVITILGNTTA 650

  Fly   518 ETAIVQQKVYLRERLHDVP--------DQDNMLWWIPIALKRQDSLSFVNTGSFKWM-NKTRQML 573
            |..|:   :..:..::|:.        ...:.||.||:.:. ..:.|.|::.:..|: ||:....
Mouse   651 ENRIL---ITQQHFIYDIGAKTKALQLQNSSYLWQIPLTIV-VGNRSHVSSEAIIWVSNKSEHHR 711

  Fly   574 ISNLPSKNMFIIVNEEEIGPFPVNYDDNNWNMLSKYLRTEEKRESIPVYTRAKLLHDAWNLAYAG 638
            |:.| .:..:|:.|..:.|.|.||||..||.:|...|  ....|.:.|..||.|:.||::||.||
Mouse   712 IAYL-DRGSWILGNINQTGYFRVNYDLRNWRLLIDQL--IRNHEVLSVSNRAALIDDAFSLARAG 773

  Fly   639 ELNFSTALNVTLFLKYERNHIVW---SPVFTFLDQVGKRLEKSSINKKFELYIIELLAPLYEYLG 700
            .|..:..|.:..:|..|::.:.|   |.....||::..|:|..:|   |..||::.:|..|..||
Mouse   774 YLPQNIPLEIIRYLSEEKDFLPWHAASRALYPLDKLLDRMENYNI---FNEYILKQVATTYIKLG 835

  Fly   701 TAHFNEDINIT-------ELRKLTTSFLCKAGYFPCFKEARRAFNIWINSSFPNFETPVPNEYIC 758
            ....|.:.::.       |||:......|..|...|.::|....:.||:|:.......|.:...|
Mouse   836 WPRNNFNGSLVQASYQHEELRREVIMLACSFGNKHCHQQASTLISDWISSNRNRIPLNVRDIVYC 900

  Fly   759 SIFK------WGSMKEWMFGLDRLCEFPKSRIQSDRTHLLKMLAGCPAQRDKIFILLELAILKNI 817
            :...      |..:  ||       :|..:...|::..||:.|. |...|:.:..||.|::  |.
Mouse   901 TGVSLLDEDVWEFI--WM-------KFHSTTAVSEKKILLEALT-CSDDRNLLSRLLNLSL--NS 953

  Fly   818 SIFSDTDKMLIISTVTSRSIGYTTLLDFLSNNWDDIHHKFYNNTNIWTKLISSATGMFSTQEGYD 882
            .:..|.|.:.:|..|.....|......|..:.|..::.::.....:.:||||..|...:|:....
Mouse   954 EVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTEGELK 1018

  Fly   883 LVKKF---YDEHYGHFGRAQHIIEKSLRNIKEGIQWSKQNIPVIEEWI 927
            .:|.|   ||      |.|.....:::..::..::|.:.....:.:|:
Mouse  1019 ELKNFMKSYD------GVASASFSRAVETVEANVRWKRFYQDELFQWL 1060

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG40470	NP_001036635.1	GluZincin	60..503	CDD:301352	113/493 (23%)
CG40470	NP_001036635.1	ERAP1_C	584..906	CDD:288671	87/340 (26%)
Trhde	NP_666353.2	M1_APN-Q_like	190..635	CDD:341064	113/492 (23%)
Trhde	NP_666353.2	ERAP1_C	720..1044	CDD:378732	87/346 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020