DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG40470 and ENPEP

DIOPT Version :9

Sequence 1:	NP_001036635.1	Gene:	CG40470 / 3355093	FlyBaseID:	FBgn0058470	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_001968.3	Gene:	ENPEP / 2028	HGNCID:	3355	Length:	957	Species:	Homo sapiens

Alignment Length:	941	Identity:	217/941 - (23%)
Similarity:	401/941 - (42%)	Gaps:	139/941 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 RLPKEVLPLSYEVLIEPHMDNQNFEGSIRMHLRWIGDSKKVYFHAHDTLLIDVSQINLTTLNMGD 116
            |||..|.|:.|::.::|.::...:.|::.:.:.....::.::.|..:|.:..:.::...:   ||
Human    92 RLPDFVNPVHYDLHVKPLLEEDTYTGTVSISINLSAPTRYLWLHLRETRITRLPELKRPS---GD 153

  Fly   117 GTLDKNVIILRGVRLPRKPVFVLYLKDKIKKGSE---CLLDIYFQGNISETEEGLFRSYYTNSGN 178
                 .|.:.|.....::...|:..::::...|.   .||.:.|.|.::.:..|.:|:.||.:|.
Human   154 -----QVQVRRCFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGWLNGSLVGFYRTTYTENGQ 213

  Fly   179 DGEEIYLATNLKPNNARRLFPCFDEPGIKVPFNVSIARPKGYITLFNTPLHNTINHPKLRSYSLD 243
              .:..:||:.:|.:||:.|||||||..|..:.:||..||.|..|.|.|:        .:..|:|
Human   214 --VKSIVATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGALSNMPV--------AKEESVD 268

  Fly   244 ------FFHTTAPMSTHAFGFVILKLHMWNEHKIVKSSDIPAINIWSNNLSSTNLLDIQNKLNVA 302
                  .|..:.||||:...|.:   |.::..|.:.:|..|              |.|..:....
Human   269 DKWTRTTFEKSVPMSTYLVCFAV---HQFDSVKRISNSGKP--------------LTIYVQPEQK 316

  Fly   303 HTT-------------IQHFFNIPLPLTKLDVIAIPSLATLPFISASGILIARESEIL------- 347
            ||.             .:.:|.:...|.|||.||||...| ..:...|::..||:.:|
Human   317 HTAEYAANITKSVFDYFEEYFAMNYSLPKLDKIAIPDFGT-GAMENWGLITYRETNLLYDPKESA 380

  Fly   348 ----KKDVFEISRELIYQWIGIWITPEWWTDANVNKALISF------------------IASEIV 390
                ::....::.||::||.|..:|.:||.|..:|:...||                  :..|.|
Human   381 SSNQQRVATVVAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLEDV 445

  Fly   391 FEINGGIEFNGKYPMTILYSLYYELSKRYPNSHITGIKHEFASIKVQLIIRMLSLTVGKYTFRLG 455
            ..:.........:|:.:..:...|::     |...||.:.    |...|:|||...:....|:.|
Human   446 LPVQEDDSLMSSHPIIVTVTTPDEIT-----SVFDGISYS----KGSSILRMLEDWIKPENFQKG 501

  Fly   456 IQSFICDYKFKTYKSSDFWNAITTQAKADNSLDSDLSILSIAESWLEHSRLPLVTIIRDYDSETA 520
            .|.::..|:||..|:||||.|:...::        |.:..:.::|......|::.:    :....
Human   502 CQMYLEKYQFKNAKTSDFWAALEEASR--------LPVKEVMDTWTRQMGYPVLNV----NGVKN 554

  Fly   521 IVQQKVYLRERLH--DVPDQDNMLWWIPIALKRQDSLSFVNTGSFKWMNKTRQMLISNLPSKNMF 583
            |.|::..|..|.:  ..|......|.||:.....:..|.|   .|....|....|.|:.||.|.|
Human   555 ITQKRFLLDPRANPSQPPSDLGYTWNIPVKWTEDNITSSV---LFNRSEKEGITLNSSNPSGNAF 616

  Fly   584 IIVNEEEIGPFPVNYDDNNWNMLSKYLRTEEKRESIPVYTRAKLLHDAWNLAYAGELNFSTALNV 648
            :.:|.:.||.:.|||:...|:.::..|....|..|..  .||.|:.||:.||.|..|::..|||:
Human   617 LKINPDHIGFYRVNYEVATWDSIATALSLNHKTFSSA--DRASLIDDAFALARAQLLDYKVALNL 679

  Fly   649 TLFLKYERNHIVWSPVFTFLDQVGKRLE-KSSINKKFELYIIELLAPLYEYLGTAHFNEDINITE 712
            |.:||.|.|.:.|..|.:.:..:....| ...:....|.|....:.|:.:.||.....:  ::|:
Human   680 TKYLKREENFLPWQRVISAVTYIISMFEDDKELYPMIEEYFQGQVKPIADSLGWNDAGD--HVTK 742

  Fly   713 -LRKLTTSFLCKAGYFPCFKEARRAFNIWINSSFPNFETPVPNEYICSIFKWGSMK-----EWMF 771
             ||.....|.||.|.......|...|..|:|.:     ..:|......::::|...     .|.:
Human   743 LLRSSVLGFACKMGDREALNNASSLFEQWLNGT-----VSLPVNLRLLVYRYGMQNSGNEISWNY 802

  Fly   772 GLDRLCEFPKSRIQSDRTHLLKMLAGCPAQRDKIFILLELAILKNISIFSDTDKMLIISTVTSRS 836
            .|:   ::.|:.:..::.   |:|.|..:.::...:...|.:||:.::....|...:|..::..|
Human   803 TLE---QYQKTSLAQEKE---KLLYGLASVKNVTLLSRYLDLLKDTNLIKTQDVFTVIRYISYNS 861

  Fly   837 IGYTTLLDFLSNNWDDIHHKF-YNNTNIWTKLISSATGMFSTQEGYDLVKKFYDEHYGHFGRAQH 900
            .|.....:::..|||.:.::: .||.|: .::::.|. .|:|:.....::.|:.: |...|..:.
Human   862 YGKNMAWNWIQLNWDYLVNRYTLNNRNL-GRIVTIAE-PFNTELQLWQMESFFAK-YPQAGAGEK 923

  Fly   901 IIEKSLRNIKEGIQWSKQNIPVIEEWIDHYL 931
            ..|:.|..:|..|:|.||:...|.||..:.|
Human   924 PREQVLETVKNNIEWLKQHRNTIREWFFNLL 954

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG40470	NP_001036635.1	GluZincin	60..503	CDD:301352	109/493 (22%)
CG40470	NP_001036635.1	ERAP1_C	584..906	CDD:288671	74/329 (22%)
ENPEP	NP_001968.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	44..83
		Peptidase_M1	92..482	CDD:279741	95/434 (22%)
		M1_APN_2	100..545	CDD:189008	109/497 (22%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:23888046, ECO:0007744\|PDB:4KXA, ECO:0007744\|PDB:4KXB, ECO:0007744\|PDB:4KXC, ECO:0007744\|PDB:4KXD	357..361		0/3 (0%)
		ERAP1_C	617..931	CDD:288671	75/331 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920