DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG40470 and R03G8.6

DIOPT Version :9

Sequence 1:	NP_001036635.1	Gene:	CG40470 / 3355093	FlyBaseID:	FBgn0058470	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_510175.1	Gene:	R03G8.6 / 181438	WormBaseID:	WBGene00011000	Length:	747	Species:	Caenorhabditis elegans

Alignment Length:	760	Identity:	165/760 - (21%)
Similarity:	292/760 - (38%)	Gaps:	133/760 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LFILTILLT-APGLEAFVNDFSSLHVISEVRLPKEVLPLSYEVLIEPHMDNQNFEGSIRMHLRWI 86
            :|||.|:.. |..|:|.:.|      ::..|||:.|.|..|::.|:.::....          |.
Worm     7 VFILAIIKPFASELDARIAD------VASYRLPRHVSPSHYDIHIKTYLPGYG----------WK 55

  Fly    87 GDSKKVYFHAHDTLLIDVSQ------INLTTLNMGDGTL---DKNVIILRGVRLPRKPVFVLYLK 142
            .|..|:.|..:..:|:|:.:      ::.::||:...|.   ::||.|..............||.
Worm    56 ADENKITFEGNVNILLDIKETTDKLVLHSSSLNIISATFQSDEQNVSISHWNVQTESQFLTFYLN 120

  Fly   143 DKIKKGSECLLDIYFQGNISETEEGLFRSYYTNSGNDGEEIY--LATNLKPNNARRLFPCFDEPG 205
            :.:|..|...:.|.|||.:.....|||.   |||..:...:.  .||..:...||.:.||||||.
Worm   121 NTVKVQSSAGIQINFQGKVRTDGLGLFA---TNSTREDGTVMTNFATQFETIFARNMIPCFDEPE 182

  Fly   206 IKVPFNVSIARPKGYITLFNTPLHNTINHPKLRSYSLDFFHTTAPMSTHAFGFVILKLHMWNEHK 270
            .|..:|||:..|.|     :|.|.|.|   ::.|...|.:.||....|......||.|.:
Worm   183 FKATWNVSLEHPTG-----STALSNGI---EVESKVNDDWKTTTYKKTLKMSSYILALFI----- 234

  Fly   271 IVKSSDIPAINIWSNN-------LSSTNLLDIQNKLNVAHTTIQHF---FNIPLPLTKLDVIAIP 325
                .||.......||       ....|:..:.:.||::...::.|   |.|..|:.|||.:::.
Worm   235 ----GDIQFKETILNNGVRIRVYTDPVNIDRVDHALNISRIVLEGFERQFGIRYPMEKLDFVSVQ 295

  Fly   326 SLATLPFISASGILIARESEIL--KKDVFEI-SRELIYQWIGIWITPEWWTDANVNKALISFIAS 387
            :. ....:...|::|.....::  ..||.|| ..|:.:||.|..:|.::|....:|:...|::.|
Worm   296 NF-KFGAMENWGLVIHNAYSLIGDPMDVTEIVIHEIAHQWFGNLVTMKYWDHIWLNEGFASYMTS 359

  Fly   388 -----------EIVFEIN---------GGIEFN-GKYPMTILYSLYYELSKRYPNSHITGIKHEF 431
                       ...|.:|         ||:..| ||                    :::.:.:..
Worm   360 YGLTFLDPDYQRDTFYLNCQFNPQINDGGVSLNFGK--------------------NLSSVMNNA 404

  Fly   432 ASIKVQ--LIIRMLSLTVGKYTFRLGIQSFICDYKFKTYKSSDFWNAITTQAKADNSLDSDLSIL 494
            |::.::  ..:|||....|...|...|:.::...::.....:|.:.|..|.::..::......|.
Worm   405 ATVYMKGCSFVRMLENIFGTEYFNEAIKFYLEKNQYDNVDDNDLYEAFRTSSETLDTNGKPFDIE 469

  Fly   495 SIAESWLEHSRLPLVTIIRDYDSETAIVQQKVYLRERLHDVPDQDNMLWWIPIALKRQDSLSFVN 559
            ..|..|...:..|.:.:..|....| :.|..:|..:.:.:..|..   |.|||..:.......
Worm   470 KFARCWTHQNGFPTIQVSNDNGIAT-LTQSHLYEPQLMLNECDYK---WDIPIWYQEPGEARV-- 528

  Fly   560 TGSFKWMNKTRQMLISNLPSKNMFIIVNEEEIGPFPVNYDDNNWNMLSKYLRTEEKRESIPVYTR 624
              ...|:|:....|  .|.:.:. :|:|...||.:.|.|.|..:..:::.:.....|.|:....|
Worm   529 --QMAWLNRNSTSL--ELVADDS-VIINANSIGYYEVLYSDKMYEKIAEQVAINVSRYSVNSLRR 588

  Fly   625 AKLLHDAWNLAYAGELNFSTALNVTLFLKYERNHIV-WSPVFTFLDQVGKRLEKSSINKK----- 683
            .  |||.:..:..|...|..|..:...|.:..|.|: ...|...:|.|.....||.:|.|
Worm   589 T--LHDVFRYSRDGLTPFHNAFIIAYVLVFGENEILRHESVLYLVDAVYNTNNKSIVNSKDIETV 651

  Fly   684 ---------FELYIIELLAPLYEYLGTAHFNEDINITELRKLTTS 719
                     |||:...:.:..:.........::||:..:.:|..|
Worm   652 KGLVNQIENFELFPKCVQSQTFSSCYQKRIPQNINLRAIMQLKLS 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG40470	NP_001036635.1	GluZincin	60..503	CDD:301352	105/489 (21%)
CG40470	NP_001036635.1	ERAP1_C	584..906	CDD:288671	33/151 (22%)
R03G8.6	NP_510175.1	Peptidase_M1	31..389	CDD:279741	93/388 (24%)
		M1_APN_2	39..482	CDD:189008	105/493 (21%)
		ERAP1_C	548..>622	CDD:288671	18/75 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920