DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG40470 and AC3.5

DIOPT Version :9

Sequence 1:	NP_001036635.1	Gene:	CG40470 / 3355093	FlyBaseID:	FBgn0058470	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_001256214.1	Gene:	AC3.5 / 179447	WormBaseID:	WBGene00007071	Length:	1090	Species:	Caenorhabditis elegans

Alignment Length:	1001	Identity:	224/1001 - (22%)
Similarity:	403/1001 - (40%)	Gaps:	204/1001 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 EVRLPKEVLPLSYEVLIEPHMDNQNFEGSIRMHLRWIGDSKKVYFHAHD---TLLIDVSQINL-- 109
            |:.|||.|.|:.|:|.:.|.:......|...:.|.....:.|:..:|.|   |..::..|::.
Worm   153 ELALPKNVQPVWYDVSLSPKVGGNGTMGLAHVKLNIEEPTNKIVLNAKDIEFTRNLEKIQLSKEV 217

  Fly   110 -------------TTLNMGDG-----------------TLDKNVIILRGVRL------PRKPVFV 138
                         :|..|.:|                 |...:..:..|:::      .......
Worm   218 TKRAKKSVDSGTNSTSEMPEGSGEEAMATTATTTTTESTTPVSSFVDTGIKVTNIEFDENLEKVT 282

  Fly   139 LYLKDKIKKGSECLLDIYFQGNISETEEGLFRSYYTNSGNDGEEIYLATNLKPNNA--RRLFPCF 201
            |.|..::||||..:|.|.|...:| ...||....|.||  :|:|..:.|. :|:.:  |.:||.|
Worm   283 LTLDQELKKGSTVVLKIPFTSKVS-NNNGLKEYKYKNS--EGKEQSMFTT-QPSYSYLRHVFPSF 343

  Fly   202 DEPGIKVPFNVSIARPKGYITLFNTPLH---------NTINHPKLRSYSLDFFHTTAPMSTHAFG 257
            |:...|.|..:::...||.|.:.||.:.         :|:|    :....||          ..|
Worm   344 DQEAFKAPAAITLMHSKGSIVVANTGVKTKDDGDAQTSTLN----KVLDPDF----------VIG 394

  Fly   258 FVILKLHMWNEHKIVKSSDIPAINIWSN---NLSSTNLLDIQNKLNVAHTTIQHFFNIPLPLTKL 319
            .::..       ::..:|.| .|.||:.   ..|:...||..|:   |...::|.....|....|
Worm   395 DLVAS-------EVNTTSGI-TIRIWTRPEVKHSTEQSLDYANQ---AIDAMEHILQSRLESKSL 448

  Fly   320 DVIAIPSLATLPFISASGILIARESEIL----KKDVFE-------ISRELIYQWIGIWITPEWWT 373
            |::|:|...|...:|.|.|::. |.:||    ..|:.:       ||..:..||.|....||.:.
Worm   449 DIVAVPGFQTGNRVSPSFIVLP-EEDILYNEQSNDINQKTRIARMISNRIAAQWFGGITNPEEFG 512

  Fly   374 DANVNKALISFIASEIVFEINGGIEFNGKYPMTILYSLYYELSK-----------------RYPN 421
            ...:|:||..|:..|.:.:|   ::.|.....|      ||:.|                 .:.:
Worm   513 TFWLNEALPRFLEVEALEKI---LDINSDDLWT------YEMEKILERDATATSQPLRVKNVFSS 568

  Fly   422 SHITGIKHEFASIKVQLIIRMLSLTVGKYTFRLGIQSFICDYKFKTYKSSD-----FWNAITTQA 481
            :.|..|.|||...|...::||:..:||...|...|:||:..|: ..|...|     |..|:..:.
Worm   569 ADIAEIDHEFIGKKGAAVLRMIQKSVGVNVFNKAIRSFVSSYR-SAYPYDDGLWKSFEKALGGKL 632

  Fly   482 KADNSLDSDLSILSIAESWLEHSRLPLVTIIRDYDSETAIVQQKVYLRERLHDVPDQ---DNMLW 543
            |..|  :..|.:.....:|::....|||: :...|.||..:.|:.:..:  |...:|   .|..:
Worm   633 KGWN--NEPLDVAKFVNTWVDQIGFPLVS-VEKLDDETVELSQERFKND--HKTKEQFKFRNAKY 692

  Fly   544 W----IPIALKRQDSLSFVNTGSFKWMNKTRQMLISNLPSKNMFIIVNEEEIGPFPVNYDDNNWN 604
            |    :|:.||....:     |:..|:::..::.::...|    |.:|.:..|.:.|||::..||
Worm   693 WFNWEVPLFLKSSGPV-----GNVSWLHEAFRLPLNTSDS----IYLNTDSNGVYRVNYEEKRWN 748

  Fly   605 MLSKYLRTEEKRESIPVYTRAKLLHDAWNLAYAGELNFSTALNVTLFLKYERNHIVWSPVFTFLD 669
            .::|.|  |:....:...|||:|:.|.:.||.:|.|.|.||||||.:|..|...:.|........
Worm   749 DIAKQL--EKSHGKLSERTRARLISDVFALANSGALPFETALNVTSYLPMETATVPWLIATRIFK 811

  Fly   670 QVGKRLEKSSINKKFELYIIELLAPLYEYLGTAHFNEDINITELR-------------------K 715
            ::.:|||.:.|..|...:|.:.:...:|.:.::......|..:.|                   |
Worm   812 KLTERLEGAPIQDKLNSFIYQKIHKKFEEISSSPGEASSNYLKNRLYANLLDLMAIVKPEKSNEK 876

  Fly   716 LTTSFLCKAGYF-PCFKEARRAFNIWINSSFPNFETPVPNE----YICSIFKWGSMKEWMFGLDR 775
            |...|:  .|:. ||          ..:.:|.:..:.||.:    ..|:..::|:  :.:|  :.
Worm   877 LNELFV--EGFLAPC----------QFSGNFSSDCSEVPGDLREKVYCNGVEFGN--DTVF--ET 925

  Fly   776 LCEFPKSRIQSDRTHLLKMLAGCPAQRDKIFILLELAILKNISIFSDTDKMLIISTVTSRSIGYT 840
            :.|..:..:......||:....|  .||.  ..|...||.|::  |.:...|::..:.||.:|..
Worm   926 VRELAEKEVDGAEKDLLQNSLAC--FRDP--RALRRLILDNLN--STSTVTLLLRKMNSRPVGKE 984

  Fly   841 TLLDFLSNNWDDIHHKFYNNTNIWTKLISSATGMFSTQEGYDLVKKFYDEHYGHFGRAQHIIEKS 905
            ...:::.:||..:..|.:.|.......|:.|..:...:....:::.|.:.|:    ::.|.||..
Worm   985 IATNWIIDNWSTVLKKKFKNDPETLNAIADAGIILDNEREKSMIETFMEHHH----KSTHGIESL 1045

  Fly   906 LRNIKEG---IQWSKQNIPVIEEWID 928
            .:.|:|.   |.|.||.|..:.:::|
Worm  1046 DKKIEEATTDIYWRKQKINELNDYLD 1071

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG40470	NP_001036635.1	GluZincin	60..503	CDD:301352	116/530 (22%)
CG40470	NP_001036635.1	ERAP1_C	584..906	CDD:288671	77/345 (22%)
AC3.5	NP_001256214.1	Peptidase_M1	156..574	CDD:279741	99/456 (22%)
		GluZincin	165..656	CDD:301352	116/532 (22%)
		ERAP1_C	728..1052	CDD:288671	78/351 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020