Protein Alignment CG40470 and Anpep

DIOPT Version :10

• Sequence 1: NP_001036635.1
• Gene: CG40470 / 3355093
• FlyBaseID: FBgn0058470
• Length: 941
• Species: Drosophila melanogaster
• Sequence 2: NP_032512.2
• Gene: Anpep / 16790
• MGIID: 5000466
• Length: 966
• Species: Mus musculus
• Alignment Length: 1012
• Identity: 241/1012 - (23%)
• Similarity: 430/1012 - (42%)
• Gaps: 153/1012 - (15%)

  Fly    16 MASG---TRTLFILTILL---------------------------TAPGLEAFVNDFSSLHV--- 47
            ||.|   ::||.||.|||                           |||.|....:..::...
Mouse     1 MAKGFYISKTLGILGILLGVAAVCTIIALSVVYAQEKNRNAENSATAPTLPGSTSATTATTTPAV 65

  Fly    48 -----ISEVRLPKEVLPLSYEVLIEPHMDNQN-----FEGSIRMHLRWIGDSKKVYFHAH---DT 99
                 .::.||||.::|.||.|::.|::...|     |:|           :..|.|..:   |.
Mouse    66 DESKPWNQYRLPKTLIPDSYRVILRPYLTPNNQGLYIFQG-----------NSTVRFTCNQTTDV 119

  Fly   100 LLIDVSQINLT-------TLNMGDGT----LDKNVIILRGVRLPRKPVFVLYLKDKIKKGSECLL 153
            ::|...::|.|       .|...|||    :||..::      .|....|::|:..:.:|.:..:
Mouse   120 IIIHSKKLNYTLKGNHRVVLRTLDGTPAPNIDKTELV------ERTEYLVVHLQGSLVEGRQYEM 178

  Fly   154 DIYFQGNISETEEGLFRSYYTNSGNDGEEIYLATNLKPNNARRLFPCFDEPGIKVPFNVSIARPK 218
            |..|||.:::...|.:||.|..  .|.:::...|.::..:||:.|||||||.:|..||:::..|.
Mouse   179 DSQFQGELADDLAGFYRSEYME--GDVKKVVATTQMQAADARKSFPCFDEPAMKAMFNITLIYPN 241

  Fly   219 GYITLFNTPLHNTINHPKLRSYSLDFFHTTAPMSTHAFGFVILKLHMWNEHKIVK--SSDIPAIN 281
            ..|.|.|.....:..:|:..|.::..||:|..|||:...:::      :|.|.:.  |::...|.
Mouse   242 NLIALSNMLPKESKPYPEDPSCTMTEFHSTPKMSTYLLAYIV------SEFKNISSVSANGVQIG 300

  Fly   282 IWSNNLSSTNLLDIQNKLNVAHTTIQHF---FNIPLPLTKLDVIAIPSL--------ATLPFISA 335
            ||:.. |:.:.......|||....:..|   :|...||.|.|.||:|..        ..:.:..:
Mouse   301 IWARP-SAIDEGQGDYALNVTGPILNFFAQHYNTSYPLPKSDQIALPDFNAGAMENWGLVTYRES 364

  Fly   336 SGILIARESEILKKD--VFEISRELIYQWIGIWITPEWWTDANVNKALISFIA------SEIVFE 392
            |.:..::.|.|..|:  |..|:.||.:||.|..:|..||.|..:|:...|::.      :|..:.
Mouse   365 SLVFDSQSSSISNKERVVTVIAHELAHQWFGNLVTVAWWNDLWLNEGFASYVEYLGADYAEPTWN 429

  Fly   393 INGGIEFNGKYPMTILYSLYYELSKRYPNSHI---TGIKHEFASI---KVQLIIRMLSLTVGKYT 451
            :...:..|..|.:..:.:|........|...|   ..|...|.||   |...:|||||..:.:..
Mouse   430 LKDLMVLNDVYRVMAVDALASSHPLSSPADEIKTPDQIMELFDSITYSKGASVIRMLSSFLTEDL 494

  Fly   452 FRLGIQSFICDYKFKTYKSSDFWNAITTQAKADNSLDSDLSILSIAESWLEHSRLPLVTIIRDYD 516
            |:.|:.|::..|::......|.|..:........::....::.:|.:.|:.....|::|:    :
Mouse   495 FKKGLSSYLHTYQYSNTVYLDLWEHLQKAVNQQTAVQPPATVRTIMDRWILQMGFPVITV----N 555

  Fly   517 SETAIVQQKVYLRERLHDV--PDQDNMLWWIPIALKRQDSLSFVNTG--SFKWMNKTRQMLISNL 577
            :.|..:.||.:|.:...:|  |.:.|.:|..||        .|:.:|  ...|::..:.......
Mouse   556 TNTGEISQKHFLLDSKSNVTRPSEFNYIWIAPI--------PFLKSGQEDHYWLDVEKNQSAKFQ 612

  Fly   578 PSKNMFIIVNEEEIGPFPVNYDDNNWNMLSKYLRTEEKRESIPVYTRAKLLHDAWNLAYAGELNF 642
            .|.|.:|::|....|.:.||||:|||..|...|:|:  ...|||..||:::||::|||.|..:..
Mouse   613 TSSNEWILLNINVTGYYLVNYDENNWKKLQNQLQTD--LSVIPVINRAQIIHDSFNLASAKMIPI 675

  Fly   643 STALNVTLFLKYERNHIVWSPVFTFLDQVGKRLEKSSINKKFELYIIELLAPLYEYLGTAHFN-- 705
            :.||:.||||..|..::.|....:.|:......::|.:....:.|:.:.:.||:.|......|
Mouse   676 TLALDNTLFLVKEAEYMPWQAALSSLNYFTLMFDRSEVYGPMKRYLKKQVTPLFFYFQNRTNNWV 740

  Fly   706 -------EDINITELRKLTTSFLCKAGYFPCFKEARRAFNIWINSSFPNFETPVPN---EYICSI 760
                   |..|  |:..::|:  |.:|...|.......::.|:.:  ||..|..||   ...|:.
Mouse   741 NRPPTLMEQYN--EINAISTA--CSSGLKECRDLVVELYSQWMKN--PNNNTIHPNLRSTVYCNA 799

  Fly   761 FKWGSMKEWMFGLDRLCEFPKSRIQSDRTHLLKMLAGCPAQRDKIFILLELAILKNISIFSDTDK 825
            ..:|..:||.|..:   :|..:.:.::...|...||   ..:|...:...|:...|.......|.
Mouse   800 IAFGGEEEWNFAWE---QFRNATLVNEADKLRSALA---CSKDVWILNRYLSYTLNPDYIRKQDT 858

  Fly   826 MLIISTVTSRSIGYTTLLDFLSNNWDDIHHKFYNNTNIWTKLISSATGMFSTQEGYDLVKKF-YD 889
            ...|.::.|...|:..:.||:.:||..:...:...:..:..||...|..||::.....:::| .|
Mouse   859 TSTIISIASNVAGHPLVWDFVRSNWKKLFENYGGGSFSFANLIQGVTRRFSSEFELQQLEQFKAD 923

  Fly   890 EHYGHFGRAQHIIEKSLRNIKEGIQWSKQNIPVIEEW 926
            .....||.....:|::|...:..|.|.|:|...:.:|
Mouse   924 NSATGFGTGTRALEQALEKTRANIDWVKENKDAVFKW 960

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG40470	NP_001036635.1	GluZincin	60..502	CDD:472708	117/487 (24%)
		ERAP1_C	583..910	CDD:463368	83/339 (24%)
Anpep	NP_032512.2	Cytosolic Ser/Thr-rich junction	33..68		4/34 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	42..64		4/21 (19%)
		Metalloprotease	69..966		227/944 (24%)
		M1_APN-Q_like	84..545	CDD:341064	117/486 (24%)
		ERAP1_C	618..945	CDD:463368	83/340 (24%)