DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG40470 and trhde

DIOPT Version :9

Sequence 1:	NP_001036635.1	Gene:	CG40470 / 3355093	FlyBaseID:	FBgn0058470	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	XP_002939988.3	Gene:	trhde / 100489066	XenbaseID:	XB-GENE-1013649	Length:	1020	Species:	Xenopus tropicalis

Alignment Length:	946	Identity:	233/946 - (24%)
Similarity:	398/946 - (42%)	Gaps:	134/946 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 VRLPKEVLPLSYEVLIEPHMDNQNFEGSIRMHLRWIGDSKKVYFHAHDTLLIDVSQINLTTLNMG 115
            :|||..:.||.|.:::...|:|..|.|.:.:.:..:..|:.:..|||        ::.:..:.:.
Frog   134 LRLPTHLRPLHYNLMVTAFMNNFTFCGEVNVEIECLNSSRYIVVHAH--------RLTVERVQVA 190

  Fly   116 DGTLDKNVIILRGVRLPRKPVFVLYLKDKIKKGSECLLDIYFQGNISETEEGLFRSYYTNSGNDG 180
            :..:...|.:......|:..|.|:.|...::......|.|.:...|.....|.|||.|.   ..|
Frog   191 EDRVAGEVKVSHYFPYPQNQVLVVVLNRSLEAQKSYNLKIIYSAIIENELLGFFRSSYV---LHG 252

  Fly   181 EEIYLA-TNLKPNNARRLFPCFDEPGIKVPFNVSIARPKGYITLFNTPLHNTINHPKLRSYSLDF 244
            |...|| |...|.:||:.|||||||..|..|.:||.....|::|.|.|:..::...  ..:..|.
Frog   253 ERRSLAVTQFSPIHARKAFPCFDEPIYKATFKISIRHQTSYLSLSNMPVETSVFEE--GGWVTDH 315

  Fly   245 FHTTAPMSTHAFGF---------------VILKLHMWNEHKIVKSSDIPAINIWSNNLSSTNLLD 294
            |..|..|||:...:               |:::|:. ....|.:.|...|:||      :..||:
Frog   316 FSQTPLMSTYYLAWAVCNFTFKEAVTQSGVVVRLYA-RPDAIRRGSGDYALNI------TKRLLE 373

  Fly   295 IQNKLNVAHTTIQHFFNIPLPLTKLDVIAIPSLATLPFISAS--GILIARESEILKK-------- 349
            .          .:.:|.:|..|.|||::|:|.   .|:.:..  |:.:..|..||..
Frog   374 F----------YEDYFRVPYSLPKLDLLAVPK---HPYAAMENWGLSVFVEQRILLDPSISSISY 425

  Fly   350 --DV-FEISRELIYQWIGIWITPEWWTDANVNKALISFIASEIVFEINGGIEFNGK---YP---- 404
              || ..|..|:.:||.|..:||.||.|..:.:.|..:            .||.|.   ||
Frog   426 LLDVTMVIVHEICHQWFGDLVTPIWWEDVWLKEGLAHY------------FEFVGTDYLYPGWNM 478

  Fly   405 --MTILYSLYYE------LSKRYPNSH----ITGIKHEF---ASIKVQLIIRMLSLTVGKYTFRL 454
              ...|..:.:|      |:..:|.|.    .|.|...|   |..|...:||||:..:|...|:.
Frog   479 EKQRFLTDVLHEVMLLDGLASSHPVSQEVLKATDIDRVFDWIAYKKGAALIRMLANFMGHKVFQR 543

  Fly   455 GIQSFICDYKFKTYKSSDFWNAITTQAKADNSLDSDLSILSIAESWLEHSRLPLVTIIR-DYDSE 518
            |:|.::..:|:.....:|.||.:|...|.:..|   |:|..:.:.|......|::||:| |...:
Frog   544 GLQDYLTTHKYGNAARNDLWNTLTKVLKNEGKL---LNIREVMDQWTLQMGYPVITILRNDTTDD 605

  Fly   519 TAIVQQKVYL---RERLHDVPDQD-NMLWWIPIALKRQDSLSFVNTGSFKWM-NKTRQMLISNLP 578
            ...:.|:.:|   .:|..|...:: :.||.||:.: ...:.|.::..:..|: ||:....|.:|.
Frog   606 IITITQEHFLYNIDKRTRDKEFRNKSSLWQIPLTI-AVGNTSHISPQAIIWVSNKSEYHRIPSLD 669

  Fly   579 SKNMFIIVNEEEIGPFPVNYDDNNWNMLSKYLRTEEKRESIPVYTRAKLLHDAWNLAYAGELNFS 643
            ..| :::.|.::||.|.||||..||.:|:..|.  ...|.|.|..||.|:.||:|||.||.|..:
Frog   670 ESN-WVLGNLDQIGYFRVNYDVRNWRLLTDQLM--RNSEVISVSNRAALIDDAFNLARAGYLTQN 731

  Fly   644 TALNVTLFLKYERNHIVWSPVFTFLDQVGKRLEKSSINKKFELYIIELLAPLYEYLG-------- 700
            ..|.:..:|..|::.:.|......|..:.|.|:::.....|..||::.::.:|..||
Frog   732 IPLEIIRYLSEEKDFLPWHAASRALYPLDKLLDRTEDYSIFSEYILKQVSTMYFRLGWPTNGQNG 796

  Fly   701 ----TAHFNEDINITELRKLTTSFLCKAGYFPCFKEARRAFNIWINSSFPNFETPVPNEYICSIF 761
                |::..|     |||:......|..|...|.::|....:.||:|:.......|.:...|:..
Frog   797 SAVPTSYQTE-----ELRREVIMLACSFGNKQCHQKAATMISDWISSNRNRIPPNVRDIVYCTGV 856

  Fly   762 KWGSMKEWMFGLDRLCEFPKSRIQSDRTHLLKMLAGCPAQRDKIFILLELAILKNISIFSDTDKM 826
            .......|.|   ...:|..|...|::..||:.|. |...|:.:..||.|::  |..:..|.|.:
Frog   857 SLMDEDVWEF---IWMKFHSSTAVSEKKILLEALT-CSDNRNLLNRLLNLSL--NSEVVLDQDAI 915

  Fly   827 LIISTVTSRSIGYTTLLDFLSNNWDDIHHKFYNNTNIWTKLISSATGMFSTQEGYDLVKKFYDEH 891
            .:|..|.....|......|..:.|..::.::.....:.:||||..|...:|:|..:.:|.|..:|
Frog   916 DVIIHVARNPHGRDLAWKFFRDKWKILNARYGEALFMNSKLISGVTEFLNTEEELNELKDFIQQH 980

  Fly   892 YGHFGRAQHIIEKSLRNIKEGIQWSKQNIPVIEEWI 927
            .|  |.|...:.::...:...::|.......:.:|:
Frog   981 KG--GSAVASLSRATETVDANVRWQHLYRDELFQWL 1014

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG40470	NP_001036635.1	GluZincin	60..503	CDD:301352	120/493 (24%)
CG40470	NP_001036635.1	ERAP1_C	584..906	CDD:288671	87/333 (26%)
trhde	XP_002939988.3	M1_APN-Q_like	143..588	CDD:341064	120/492 (24%)
trhde	XP_002939988.3	ERAP1_C	673..998	CDD:403137	87/339 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020