DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG40470 and LOC100004744

DIOPT Version :9

Sequence 1:	NP_001036635.1	Gene:	CG40470 / 3355093	FlyBaseID:	FBgn0058470	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	XP_001920418.2	Gene:	LOC100004744 / 100004744	-ID:	-	Length:	935	Species:	Danio rerio

Alignment Length:	1005	Identity:	232/1005 - (23%)
Similarity:	415/1005 - (41%)	Gaps:	185/1005 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 MASGTRTLFILTILLTAPGLEAFVNDFSSLHVISEVRLPKEVLPLSYEVLIEPHMDNQNFEGSIR 80
            |||....:.:.|:.| .|..|:.|..:      .|.|||..:.|..|.:.:.|.:...:
Zfish    18 MASLATIVGLWTVQL-LPTTESHVEPW------KEYRLPDTLFPHYYNITLWPRLQPDD------ 69

  Fly    81 MHLRWI--GDSKKVY--FHAHDTLLIDVSQINLTTLNMGDGTLDKNVIILRGVRLPRKP------ 135
             |..::  |:|..|:  ....|.::|..:::|||:   .||.|.|    |........|
Zfish    70 -HGLYVFTGNSSVVFKCLRETDIIIIHCNKLNLTS---EDGYLAK----LSAFSTSEVPSVKKTW 126

  Fly   136 ------VFVLYLKDKIKKGSECLLDIYFQGNISETEEGLFRSYYTNSGNDGEEIYLATN-LKPNN 193
                  ..||.|..|:|.|...:|...|.|.:::...||:||.|   ..|||:..:||: :.|.:
Zfish   127 IEEMTQYLVLQLNGKLKAGELYVLYTEFVGELADDLAGLYRSEY---DEDGEKKIVATSQMHPTH 188

  Fly   194 ARRLFPCFDEPGIKVPFNVSIARPKGYITLFN-TPLHNTINHPKLRSYSLDFFHTTAPMSTHAFG 257
            ||:.|||||||.:|..|::::...:|.:.|.| ..:.|.......:..::..|..|..||::...
Zfish   189 ARKTFPCFDEPAMKAVFHITLIHDRGTVALSNGMEIENVDTIVDGQPVTVTTFEPTKIMSSYLLA 253

  Fly   258 FVILKLHMWNEHKIVKSSDIPAINIWSNNLSSTNLLDIQN-----KLNVAHTTI---QHFFNIPL 314
            .|:      :::..|.|:|...|.||:...:      |::     .||:....:   ::::|:|.
Zfish   254 LVV------SDYTNVTSADGTLIRIWARKKA------IEDGHGDYALNITGPILKFFENYYNVPY 306

  Fly   315 PLTKLDVIAIPSLATLPFISAS---GILIARESEIL-----------KKDVFEISRELIYQWIGI 365
            ||:|.|.||:|..    :..|.   |:::.|||.:|           ::....|:.||.:.|.|.
Zfish   307 PLSKSDQIALPDF----YFGAMENWGLVMYRESNLLYDPTVSSNANKERTATIIAHELAHMWFGN 367

  Fly   366 WITPEWWTDANVNKALISFIASEIVFEINGGIEF-----NGKYPMTILYSLYYELS-KRYPNSHI 424
            .:|.:||.:..:|:...|:::..       |.:|     |.| .:.||..::...: ....:||.
Zfish   368 LVTLKWWNEVWLNEGFASYVSYL-------GADFAEPSWNVK-DLIILKDVHRVFAVDALASSHP 424

  Fly   425 TGIKHE-----------FASI---KVQLIIRMLSLTVGKYTFRLGIQSFICDYKFKTYKSSDFWN 475
            ...|.|           |.::   |...::||||..:.:..|..|:.:::..:..:.....|.|:
Zfish   425 LSSKEEDIIKPEQIIEQFDTVSYSKGASVLRMLSDFLTEPVFVQGLNTYLTMFADQNTVGEDLWD 489

  Fly   476 AITTQAKADNSLDSDLSILSIAESWLEHSRLPLVTIIRDYDSETAIVQQKVYLRERLHDVPDQD- 539
            .:.|......:: ..||:..|.:.|:.....|:||:    ::.|..|.|..:|.:     |:..
Zfish   490 HLQTAVNKTGTV-LPLSVKVIMDRWVLQMGFPVVTV----NTTTGQVSQMHFLLD-----PESSL 544

  Fly   540 ------NMLWWIPIALKRQDSLSFVNTGSFKWMN----KTRQMLISNLPSKN-------MFIIVN 587
                  |..|.:||                .||.    ::|..|:......|       .::::|
Zfish   545 QRTSPFNYEWIVPI----------------NWMKSKMVQSRFWLLERTAVYNDMKTTGSEWVLLN 593

  Fly   588 EEEIGPFPVNYDDNNWNMLSKYLRTEEKRESIPVYTRAKLLHDAWNLAYAGELNFSTALNVTLFL 652
            ....|.:.||||..||..|...|  .|..:.|.|..||:::.||:|||.|..:..:.||..|.:|
Zfish   594 LNITGYYRVNYDIGNWERLLNQL--AENHKVISVINRAQIVDDAFNLARAKIIPVTLALKTTTYL 656

  Fly   653 KYERNHIVWSPVFTFLDQVGKRLEKSSINKKFELYIIELLAPLYEYLGT----------AHFNED 707
            ..||.::.|......||.......::.:.:..:.|..:.:.||::|..|          .|.::.
Zfish   657 SEEREYMPWQSALNNLDYFYLMFTQTEVYRLLQSYTKKQVTPLFDYFKTITEDWSDVPSGHTDQY 721

  Fly   708 INITELRKLTTSFLCKAGYFPCFKEARRAFNIWINSSFPNFETPVPN---EYICSIFKWGSMKEW 769
            ..:..:|     |.|..|...|.......:..|::.  ||.....||   ...||....|..:||
Zfish   722 NQVNAIR-----FACSTGVDECQNLTSSWYKQWMDQ--PNHNPIHPNLRSTVYCSAIATGGAEEW 779

  Fly   770 MFGLDRLCEFPKSRIQSDRTHLLKMLAGCPAQRDKIFILLELAILKNISIFSDTDKMLIISTVTS 834
            .||...   |..:.|::|     |:::.....:::..:...|....:.|:....|...:|..:.|
Zfish   780 DFGWTM---FKNAAIEAD-----KLMSSLACAKNQTLLKRYLGYTLDPSMIRKQDATSVIVYIAS 836

  Fly   835 RSIGYTTLLDFLSNNWDDIHHKFYNNTNIWTKLISSATGMFSTQEGYDLVKKFYDEH--YGHFGR 897
            ...|.....:|:.|.|:.:..::...:..:..|||..|..|||:...:.:.||..::  .| ||.
Zfish   837 NPDGQKLAWEFVRNKWEYMFTEYGVGSFNFASLISGITKTFSTEAELEQLLKFKSDNSEIG-FGS 900

  Fly   898 AQHIIEKSLRNIKEGIQWSKQNIPVIEEWI 927
            |...:|:::...|..|:|..:|...|.:|:
Zfish   901 ATAALEQAIEKTKANIKWVAENQEDITDWL 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG40470	NP_001036635.1	GluZincin	60..503	CDD:301352	116/502 (23%)
CG40470	NP_001036635.1	ERAP1_C	584..906	CDD:288671	80/336 (24%)
LOC100004744	XP_001920418.2	Peptidase_M1	47..450	CDD:279741	106/443 (24%)
		M1_APN_2	57..520	CDD:189008	116/504 (23%)
		ERAP1_C	590..911	CDD:288671	80/338 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.020