DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mRpS5 and MRPS5

DIOPT Version :9

Sequence 1:	NP_001036652.1	Gene:	mRpS5 / 3355089	FlyBaseID:	FBgn0287187	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_114108.1	Gene:	MRPS5 / 64969	HGNCID:	14498	Length:	430	Species:	Homo sapiens

Alignment Length:	329	Identity:	139/329 - (42%)
Similarity:	194/329 - (58%)	Gaps:	19/329 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TLIRRLFNQACSRNIFILNQSLLSSHEPILPGYIGLRNTSFFNKLPAEDIWRGVTAVSNAGKKRG 68
            :|.|.|..|.|     |.:.|.|.|.:        .|..|||.||.|:::|:|..|.:.||.|:|
Human    62 SLSRALQTQCC-----ISSPSHLMSQQ--------YRPYSFFTKLTADELWKGALAETGAGAKKG 113

  Fly    69 RGKGSGKKVAKDLNKGQSIGFGKCGRIWPGLNSPLIRGN--ELINQQKLNENLDRENGILKLRDS 131
            |||.:.||..||||:||.||.|:.|.:|||||.||::..  :.|.|:...|....|..:::.|:.
Human   114 RGKRTKKKKRKDLNRGQIIGEGRYGFLWPGLNVPLMKNGAVQTIAQRSKEEQEKVEADMIQQREE 178

  Fly   132 MGSFKLMKLNPIDRGWSGSKMPGRSIGPPDPVG--DEEFVSFDTRVLENKIVFIMKGNMGRKRRY 194
            ....|.||:.. :|||||:...|.|:||||| |  .|.:..||||:||.:.||.|....|||:..
Human   179 WDRKKKMKVKR-ERGWSGNSWGGISLGPPDP-GPCGETYEDFDTRILEVRNVFTMTAKEGRKKSI 241

  Fly   195 SVLSVTGNGNGLAGFATAKAPEVRTALRKSKNRAGQKLINISLCENRTIFHDFRTDFGKTKIFCF 259
            .||...|||.|.|||:..||.:...|.||:||||...|..|...|:.|||||....|.:|.|...
Human   242 RVLVAVGNGKGAAGFSIGKATDRMDAFRKAKNRAVHHLHYIERYEDHTIFHDISLRFKRTHIKMK 306

  Fly   260 QKPDGYGLVCHRAIQTICKVIGIKDLYAKIEGSTNIQNIAKAFFIGLMTQRSYQYIANETNSNIV 324
            ::|.||||.|||||.|||::|||||:|||:.||.|:.::.:..|.||..|.::|.:|::...::|
Human   307 KQPKGYGLRCHRAIITICRLIGIKDMYAKVSGSINMLSLTQGLFRGLSRQETHQQLADKKGLHVV 371

  Fly   325 QLQK 328
            ::::
Human   372 EIRE 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mRpS5	NP_001036652.1	Ribosomal_S5	171..235	CDD:278748	31/63 (49%)
		rpsE_bact	178..323	CDD:130093	65/144 (45%)
		Ribosomal_S5_C	251..318	CDD:281681	33/66 (50%)
MRPS5	NP_114108.1	RpsE	221..373	CDD:223176	69/151 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143207
Domainoid	1	1.000	107	1.000	Domainoid score	I6548
eggNOG	1	0.900	-	-		E1_COG0098
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32726
Inparanoid	1	1.050	239	1.000	Inparanoid score	I3364
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45760
OrthoDB	1	1.010	-	-		D1262134at2759
OrthoFinder	1	1.000	-	-		FOG0003644
OrthoInspector	1	1.000	-	-		oto90368
orthoMCL	1	0.900	-	-		OOG6_104516
Panther	1	1.100	-	-	LDO	PTHR13718
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1257
SonicParanoid	1	1.000	-	-		X5316
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800