DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Snap25 and SNAP23

DIOPT Version :9

Sequence 1:	NP_001036641.1	Gene:	Snap25 / 3355084	FlyBaseID:	FBgn0011288	Length:	212	Species:	Drosophila melanogaster
Sequence 2:	XP_016878181.1	Gene:	SNAP23 / 8773	HGNCID:	11131	Length:	224	Species:	Homo sapiens

Alignment Length:	200	Identity:	100/200 - (50%)
Similarity:	129/200 - (64%)	Gaps:	31/200 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 EELQINAQGVADESLESTRRMLALCEESKEAGIRTLVALDDQGEQLDRIEEGMDQINADMREAEK 83
            ||:|..|..:.|||||||||:|.|..||::|||:|:..||:|.|||:|||||:||||.||||.||
Human     7 EEIQQRAHQITDESLESTRRILGLAIESQDAGIKTITMLDEQKEQLNRIEEGLDQINKDMRETEK 71

  Fly    84 NLSGMEKCCGICVLPCNK--------------SQSFKEDDGTWKGNDDGK-----VVNNQPQRVM 129
            .|:.:.||||:||.|||:              .:|.|....||  .|.|:     ||:.||..|
Human    72 TLTELNKCCGLCVCPCNRFSDVGCFYETRTKNFESGKAYKTTW--GDGGENSPCNVVSKQPGPV- 133

  Fly   130 DDRNGMM-------AQAGYIGRITNDAREDEMEENMGQVNTMIGNLRNMALDMGSELENQNRQID 187
              .||.:       |..|||.||||||||||||||:.||.:::|||::|||::|:|::.||.||.
Human   134 --TNGQLQQPTTGAASGGYIKRITNDAREDEMEENLTQVGSILGNLKDMALNIGNEIDAQNPQIK 196

  Fly   188 RINRK 192
            ||..|
Human   197 RITDK 201

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snap25	NP_001036641.1	SNARE_SNAP25N_23N	28..87	CDD:277242	39/58 (67%)
		SNAP-25	98..149	CDD:279208	24/76 (32%)
		SNARE_SNAP25C	151..209	CDD:277238	23/41 (56%)
SNAP23	XP_016878181.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156686
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3065
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60093
OrthoDB	1	1.010	-	-		D495812at33208
OrthoFinder	1	1.000	-	-		FOG0000822
OrthoInspector	1	1.000	-	-		mtm8607
orthoMCL	1	0.900	-	-		OOG6_102919
Panther	1	1.100	-	-	O	PTHR19305
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3593
SonicParanoid	1	1.000	-	-		X1125
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.750