DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Snap25 and ric-4

DIOPT Version :9

Sequence 1:	NP_001036641.1	Gene:	Snap25 / 3355084	FlyBaseID:	FBgn0011288	Length:	212	Species:	Drosophila melanogaster
Sequence 2:	NP_001123033.1	Gene:	ric-4 / 179427	WormBaseID:	WBGene00004364	Length:	234	Species:	Caenorhabditis elegans

Alignment Length:	213	Identity:	122/213 - (57%)
Similarity:	157/213 - (73%)	Gaps:	12/213 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPADPSEEVAPQVPKTELEELQINAQGVADESLESTRRMLALCEESKEAGIRTLVALDDQGEQLD 65
            :|||.|:         ||:.|.:.......|||||||||||||||||||||:|||.||||||||:
Worm    30 LPADMSD---------ELKGLNVGIDEKTIESLESTRRMLALCEESKEAGIKTLVMLDDQGEQLE 85

  Fly    66 RIEEGMDQINADMREAEKNLSGMEKCCGICVLPCNKSQSFKEDD--GTWKGNDDGKVVNNQPQRV 128
            |.|..:|.||.||:|||.:|.|||||||:||||.||:..|::.:  ..||.:|||.|:::||:..
Worm    86 RCEGALDTINQDMKEAEDHLKGMEKCCGLCVLPWNKTDDFEKTEFAKAWKKDDDGGVISDQPRIT 150

  Fly   129 MDDRNGMMAQAGYIGRITNDAREDEMEENMGQVNTMIGNLRNMALDMGSELENQNRQIDRINRKG 193
            :.| :.|..|.|||.:||||||||||:||:.||:||:|||||||:||.:|:.|||||:|||:.|.
Worm   151 VGD-SSMGPQGGYITKITNDAREDEMDENVQQVSTMVGNLRNMAIDMSTEVSNQNRQLDRIHDKA 214

  Fly   194 ESNEARIAVANQRAHQLL 211
            :|||.|:..||:||..|:
Worm   215 QSNEVRVESANKRAKNLI 232

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snap25	NP_001036641.1	SNARE_SNAP25N_23N	28..87	CDD:277242	43/58 (74%)
		SNAP-25	98..149	CDD:279208	21/52 (40%)
		SNARE_SNAP25C	151..209	CDD:277238	37/57 (65%)
ric-4	NP_001123033.1	SNARE_SNAP25N_23N	45..107	CDD:277242	43/61 (70%)
		SNAP-25	118..170	CDD:279208	21/52 (40%)
		SNARE_SNAP25C	172..230	CDD:277238	37/57 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164670
Domainoid	1	1.000	115	1.000	Domainoid score	I3775
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H83182
Inparanoid	1	1.050	237	1.000	Inparanoid score	I2131
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60093
OrthoDB	1	1.010	-	-		D1197028at2759
OrthoFinder	1	1.000	-	-		FOG0000822
OrthoInspector	1	1.000	-	-		otm14169
orthoMCL	1	0.900	-	-		OOG6_102919
Panther	1	1.100	-	-	LDO	PTHR19305
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3593
SonicParanoid	1	1.000	-	-		X1125
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.940