DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG41099 and RIPK1

DIOPT Version :9

Sequence 1:	NP_001015359.1	Gene:	CG41099 / 3355072	FlyBaseID:	FBgn0039955	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_001341859.1	Gene:	RIPK1 / 8737	HGNCID:	10019	Length:	671	Species:	Homo sapiens

Alignment Length:	728	Identity:	131/728 - (17%)
Similarity:	235/728 - (32%)	Gaps:	255/728 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 DLLSNIQQLDWSDLNEDVVLS------------------LLRWIYTDLIDLQNDGLALDLLKAAH 148
            |:..|:.::..||..|...|.                  :::.:|.....::::...|:..|..:
Human     4 DMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMN 68

  Fly   149 RF---GLPSLLGICERALVTSVGVRSCIRFYCVAEEVGASTLLEYCSSIISTHWDDLTTDDFQHM 210
            |.   .:..|||:                   :.||...|.::||                   |
Human    69 RLRHSRVVKLLGV-------------------IIEEGKYSLVMEY-------------------M 95

  Fly   211 SGPLLFEMLKTKTKHPLHAAVRLLREDVVSLCIQKYGNSLVNTFSENGILPLEMALSSKNAKIAK 275
            ....|..:||.:...||....|::.|.:..:| ..:|..:::                |:.|...
Human    96 EKGNLMHVLKAEMSTPLSVKGRIILEIIEGMC-YLHGKGVIH----------------KDLKPEN 143

  Fly   276 SLVDN---------GMANI---NAVNMEGFSLLK----SALKNG--------------------- 303
            .||||         |:|:.   :.:|.|..:.|:    :|.|||
Human   144 ILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEK 208

  Fly   304 -DAFS---------------ANFLLDQNCLLDLPS--KPSSD----------TALHIIC-NYGPD 339
             |.:|               .|.:.:|..::.:.|  :|..|          .:|..:| ...|:
Human   209 SDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPE 273

  Fly   340 NTPEIMEVVKKI-------LQRQLNINIQNIKGETPLHIAIARRNVEMVKLLLKVPNIDINLRTY 397
            ..|....:.:|.       |:..:..:::::|.|.....|:.:|...:....:.||:...|..|
Human   274 ARPTFPGIEEKFRPFYLSQLEESVEEDVKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSAT- 337

  Fly   398 DEKCALELSLSMG------------------DHEFLIASILLS------MGARTDRTNSKTGDSL 438
            ::..:|..|..:|                  ::|..:.|.|..      .|:|.||   :|....
Human   338 EQPGSLHSSQGLGMGPVEESWFAPSLEHPQEENEPSLQSKLQDEANYHLYGSRMDR---QTKQQP 399

  Fly   439 LQVFALDRHRGEKSAIFLADFA-DLDHINFRGL----TALHIAALNNMPNLVKKLIVNGASSNLK 498
            .|..|.:|....:..:....|| ...:.||:..    ||...||               :..|..
Human   400 RQNVAYNREEERRRRVSHDPFAQQRPYENFQNTEGKGTAYSSAA---------------SHGNAV 449

  Fly   499 HIDCGLKSALHIAVEANAIDALEAF------------------VELKNKS-HDIDFNCQDINGDS 544
            |...||.|...:..:.|.:.:...|                  :.....| |:|.....:..|::
Human   450 HQPSGLTSQPQVLYQNNGLYSSHGFGTRPLDPGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNT 514

  Fly   545 PLSLCLSL-------KRTTLVPTLIRGGS----DVNGKNKNNLSPLHQSIKNEDSDISLFLLEQG 598
            |.....||       |.|....|.|:.|:    ::.|.:.:.|          ||..:.|..|..
Human   515 PTMPFSSLPPTDESIKYTIYNSTGIQIGAYNYMEIGGTSSSLL----------DSTNTNFKEEPA 569

  Fly   599 ADITALTENLDSALDLSIKHDLSEVVDAL------CRRGIALS------INKNGESPLWSALEKG 651
            |...|:.:|..|..|   || |..:.:.|      |.|.:..:      |:.:.|..  ...||.
Human   570 AKYQAIFDNTTSLTD---KH-LDPIRENLGKHWKNCARKLGFTQSQIDEIDHDYERD--GLKEKV 628

  Fly   652 YEDVAKILVRHGI 664
            |:.:.|.::|.||
Human   629 YQMLQKWVMREGI 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG41099	NP_001015359.1	BTB	67..164	CDD:279045	13/82 (16%)
		BTB	75..166	CDD:197585	13/84 (15%)
		ANK	252..385	CDD:238125	32/205 (16%)
		ANK repeat	291..322	CDD:293786	10/71 (14%)
		ANK repeat	325..362	CDD:293786	7/54 (13%)
		Ank_2	330..431	CDD:289560	24/132 (18%)
		ANK	463..595	CDD:238125	30/165 (18%)
		ANK repeat	468..501	CDD:293786	6/36 (17%)
		Ank_2	473..572	CDD:289560	22/128 (17%)
		ANK repeat	503..539	CDD:293786	8/54 (15%)
		ANK	536..660	CDD:238125	32/146 (22%)
		ANK repeat	541..572	CDD:293786	10/41 (24%)
		ANK repeat	574..637	CDD:293786	16/74 (22%)
		Ank_2	579..670	CDD:289560	24/98 (24%)
		ANK repeat	639..670	CDD:293786	8/26 (31%)
		Ank_2	644..752	CDD:289560	7/21 (33%)
		ANK repeat	672..721	CDD:293786
		ANK	721..843	CDD:238125
		ANK repeat	723..752	CDD:293786
		ANKYR	752..977	CDD:223738
		ANK repeat	754..786	CDD:293786
		ANK	820..944	CDD:238125
		ANK repeat	822..855	CDD:293786
		ANK repeat	857..888	CDD:293786
		ANK	885..1017	CDD:238125
		ANK repeat	890..921	CDD:293786
		ANK repeat	923..955	CDD:293786
		ANK repeat	996..1021	CDD:293786
		FYVE_ANFY1	1054..1116	CDD:277267
RIPK1	NP_001341859.1	STKc_RIP1	23..290	CDD:270929	50/321 (16%)
		Interaction with SQSTM1. /evidence=ECO:0000269\|PubMed:10356400	290..582		59/320 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	331..354		5/23 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	389..458		19/86 (22%)
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269\|PubMed:11734559, ECO:0000269\|PubMed:29681455	531..547		4/15 (27%)
		Death_RIP1	583..668	CDD:260048	16/65 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900