DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG41099 and SPT23

DIOPT Version :9

Sequence 1:	NP_001015359.1	Gene:	CG41099 / 3355072	FlyBaseID:	FBgn0039955	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_012905.1	Gene:	SPT23 / 853848	SGDID:	S000001503	Length:	1082	Species:	Saccharomyces cerevisiae

Alignment Length:	1038	Identity:	204/1038 - (19%)
Similarity:	346/1038 - (33%)	Gaps:	357/1038 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   247 GN--SLVNTFSEN-----GILPLEMALSSKNAKIA-----KSLVDNGMANINAVNM--------- 290
            ||  |:::::|.|     |...|:: |.|:...||     .||.|.|:.::|...|
Yeast     6 GNVSSMLHSYSANIQHNDGSPDLDL-LESELLDIALLNSGSSLQDPGLLSLNQEKMITAGTTTPG 69

  Fly   291 ---EGFSLLKSALKNGDAFSANFLLDQNCLL--DLPSKPSSDTALHIICNYGPDNTPEIMEVV-- 348
               ||      .|:: |..|...|||::...  .||.:......|..| |..|.:.|..:|::
Yeast    70 KEDEG------ELRD-DIASLQGLLDRHVQFGRKLPLRTPYANPLDFI-NINPQSLPLSLEIIGL 126

  Fly   349 KKI----LQRQLNINIQNIKGETPLHIAIARRNVEMVKLL--------LKVPNIDINLRTYDEKC 401
            .|:    .|.:|:..|:|........|.:....:...|..        |.:||.|||.||.
Yeast   127 PKVSRVETQMKLSFRIRNAHARKNFFIHLPSDCIAKDKFFTSSDDPTNLTIPNRDINERTL---- 187

  Fly   402 ALELSLSMGDHEFLIASILLSMGARTDRTNSKTGDSLLQVFALDR--HRGEKSAIFLADFADLDH 464
                        ||.|.:|.:        ::...::..|.:..:|  :|.::.|          .
Yeast   188 ------------FLDAFLLCA--------SNNNSNNFKQTYVCNRCINREKRRA----------S 222

  Fly   465 INFRGLTALHIAALNNMPNLV----KKLIV---NGASSNLKHIDCGLKSALHIAVEANAIDALEA 522
            ....||....|...|.....:    |:|.:   ||.|.|...|:..|.:  .|........|...
Yeast   223 RRKSGLNDNSIWQNNENKRAIIFNSKQLFIISNNGLSGNSNCINFDLPT--RIVCYCRHHKATNG 285

  Fly   523 FVELKNKSHDIDFNCQDINGDSPLSLCLSLKRTTLVPTLIRGGSDVNGKNKNN-----------L 576
            ||.|        |..:|.|||       .|.:|...|.:|     ::.||.:|           :
Yeast   286 FVVL--------FLLRDHNGD-------ILAKTITDPIMI-----MDKKNASNTTTPTSTSNAQV 330

  Fly   577 SPL---HQSIKNEDSDI---SLFLLEQGADITALTENLDSALDLSIKHDLSEVVDALCRRGIALS 635
            ||:   .:|..:..||:   |.|.|...:....::.|.              ::|:.|......:
Yeast   331 SPMTNDTRSFSSPQSDLNFPSEFPLPSNSKNFVISTNC--------------MLDSNCNNNNNDN 381

  Fly   636 INKNG--------------ESPLWSALEKGYEDVAKILVRHGIDTDCWDEGPEGCRQTLLHRAID 686
            .|||.              .||. |:.|......:.|...:..|.:             |||::|
Yeast   382 DNKNNIKTNTAMMNNNRHFPSPN-SSSEDSNHSFSDIHFSNNNDNN-------------LHRSLD 432

  Fly   687 -------ENKESVAIFLIQSQCDLDSSRQPG-------------PN----------GEGGDEAQD 721
                   .:..:.|:..:.|.....|:|..|             ||          ....|.:..
Yeast   433 SWSSTGFNSSSNPALTTLTSDFSAASARHTGKRQRSVNEPFMSTPNTFSRLPQKFIDSSKDISNH 497

  Fly   722 KASPLHLCCHWGQTKVL--QTLIDHGANVNLIDAESKSPL------HVAIESQ-YDEIISILLCH 777
            .:.|:.|.......:|:  |..|:.|..|.|:.::.|..|      ::|:.|| ::|...:....
Yeast   498 NSVPVALNNKPSIQRVIPAQGSINGGIEVTLLGSKFKQGLIIKFGENIALSSQCWNESTMVTYLP 562

  Fly   778 PDIDLKLRDKSGNTPFATALD-----FRNHNAAQRILDRFPTAAEQMDIRGRNFLHL-------A 830
            |.      .|.|.. ..|.:|     .||::.:.     ..|:....||     |||       |
Yeast   563 PS------SKPGPV-LVTIVDPSETSMRNNSNSS-----VSTSNSTNDI-----LHLNKYTGEKA 610

  Fly   831 ILK--DDLESVLFLLAIQV---DVNSRVHDA---------NQSSP-------------------- 861
            |..  ||.:..|..||:|:   .:|.::.||         :.|||
Yeast   611 IFTYVDDTDRQLIELALQIVGLKMNGKLEDARNIAKRIVGSDSSPSNNNAGLHSQNSSLNSYTNM 675

  Fly   862 --------------------------------------LHLAAASQNEMITRNLILAGARMNERD 888
                                                  |||||.:....:...||..|:.:|::|
Yeast   676 MRNINDEQLITEVIKSFKRNNNLSTVNLSMCDVRGRTLLHLAAFNNWYSLVSLLIKYGSHLNDQD 740

  Fly   889 AVQKLPLHIAIERGNLPAVSALIQNNADYDATDADGNNALHIAVRCAQFFIVRELLTESRVNAEA 953
            .....|||:|...|:|..:..|::.|.:......:|..|       .|||::...:.::|.:...
Yeast   741 LFGFTPLHMACINGDLRIIRLLLECNVNIMKKTRNGFIA-------KQFFLMNYTVNKTRYSNYE 798

  Fly   954 TNLKGRNPLHELCRVVEDSTAGLICELFLESMPKYPIN---IPDMDGNTPLLLSFMRGQSPLCKI 1015
            |:|..    ..|.|:.:::|.....:.|..::.:...|   ..|.|.:.    .:::.:    |.
Yeast   799 TSLFD----DILTRLTKNTTGSSDTQPFERNVSQSSFNSSLFDDDDADH----DYVQER----KY 851

  Fly  1016 LVKAGACLGTENKD--------------GINIFNFKLATDQL------LHNLLD--QLPQESP 1056
            |:...|.|..|..:              |.:|.:.:.::|::      .|.:.|  ..|.|.|
Yeast   852 LLADSAALAPEQSNCNDNTSFSILDSDSGYDISDCESSSDEIALEFFNTHKIKDFSSKPNEIP 914

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG41099	NP_001015359.1	BTB	67..164	CDD:279045
		BTB	75..166	CDD:197585
		ANK	252..385	CDD:238125	37/170 (22%)
		ANK repeat	291..322	CDD:293786	9/32 (28%)
		ANK repeat	325..362	CDD:293786	10/42 (24%)
		Ank_2	330..431	CDD:289560	25/114 (22%)
		ANK	463..595	CDD:238125	36/155 (23%)
		ANK repeat	468..501	CDD:293786	10/39 (26%)
		Ank_2	473..572	CDD:289560	24/105 (23%)
		ANK repeat	503..539	CDD:293786	7/35 (20%)
		ANK	536..660	CDD:238125	30/154 (19%)
		ANK repeat	541..572	CDD:293786	7/30 (23%)
		ANK repeat	574..637	CDD:293786	12/79 (15%)
		Ank_2	579..670	CDD:289560	18/110 (16%)
		ANK repeat	639..670	CDD:293786	7/44 (16%)
		Ank_2	644..752	CDD:289560	24/139 (17%)
		ANK repeat	672..721	CDD:293786	12/78 (15%)
		ANK	721..843	CDD:238125	32/144 (22%)
		ANK repeat	723..752	CDD:293786	8/30 (27%)
		ANKYR	752..977	CDD:223738	62/315 (20%)
		ANK repeat	754..786	CDD:293786	7/38 (18%)
		ANK	820..944	CDD:238125	42/202 (21%)
		ANK repeat	822..855	CDD:293786	12/44 (27%)
		ANK repeat	857..888	CDD:293786	12/88 (14%)
		ANK	885..1017	CDD:238125	26/134 (19%)
		ANK repeat	890..921	CDD:293786	8/30 (27%)
		ANK repeat	923..955	CDD:293786	6/31 (19%)
		ANK repeat	996..1021	CDD:293786	3/24 (13%)
		FYVE_ANFY1	1054..1116	CDD:277267	2/3 (67%)
SPT23	NP_012905.1	ANKYR	79..>209	CDD:223738	33/154 (21%)
		IPT	508..578	CDD:238050	17/76 (22%)
		PLN03192	<612..>765	CDD:215625	29/152 (19%)
		Ank_2	694..772	CDD:403870	18/77 (23%)
		ANK repeat	709..740	CDD:293786	9/30 (30%)
		ANK repeat	742..767	CDD:293786	7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343612
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930