DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG41099 and LRRK1

DIOPT Version :9

Sequence 1:NP_001015359.1 Gene:CG41099 / 3355072 FlyBaseID:FBgn0039955 Length:1124 Species:Drosophila melanogaster
Sequence 2:NP_078928.3 Gene:LRRK1 / 79705 HGNCID:18608 Length:2015 Species:Homo sapiens


Alignment Length:1349 Identity:240/1349 - (17%)
Similarity:425/1349 - (31%) Gaps:451/1349 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    70 KNTYADIYIRSQTRVFPAHKIVLHA----RSEKW-----------------------GNDLLSNI 107
            |:|..:|.   ||...|.   |:|.    |:.||                       |...::.:
Human   651 KSTLLEIL---QTGRAPQ---VVHGEATIRTTKWELQRPAGSRAKVESVEFNVWDIGGPASMATV 709

  Fly   108 QQLDWSD-----------LNEDVVLSLLRWIYTDLIDLQND-----GLALDLLKAAHRF------ 150
            .|..::|           |.|:.|.:|..|:........|.     |..|||::|..|.      
Human   710 NQCFFTDKALYVVVWNLALGEEAVANLQFWLLNIEAKAPNAVVLVVGTHLDLIEAKFRVERIATL 774

  Fly   151 -----------------GLPS-----LLGICERALVTSVGVRSCIRFY--CVAEEVGAS------ 185
                             |.|.     |..|..::|....|:|..| |:  |..::||::      
Human   775 RAYVLALCRSPSGSRATGFPDITFKHLHEISCKSLEGQEGLRQLI-FHVTCSMKDVGSTIGCQRL 838

  Fly   186 -------TLLEYCSSIISTHWDDLTTDDFQHMSGPLLFEMLK------TKTKHPLHAAVRLLRED 237
                   :.|....::::........||.|:::...|.::::      .|....|.:|:..|.|.
Human   839 AGRLIPRSYLSLQEAVLAEQQRRSRDDDVQYLTDRQLEQLVEQTPDNDIKDYEDLQSAISFLIET 903

  Fly   238 VVSLCIQKYGNSLVNTFSENGILPLEMALSSKNAKIAKSLVDNGMANINAVNM--EGFSLLKSAL 300
            ...|......:.|.|.:..:.|...|......|.|.::|:..||:.....:.|  .|....:...
Human   904 GTLLHFPDTSHGLRNLYFLDPIWLSECLQRIFNIKGSRSVAKNGVIRAEDLRMLLVGTGFTQQTE 968

  Fly   301 KNGDAFSANF-----LLDQNCLLD--LPSKPSSDT--ALHIICN---------YGP--------- 338
            :....|.|.|     :.:.:.||.  |||||..||  ..|...|         :.|         
Human   969 EQYFQFLAKFEIALPVANDSYLLPHLLPSKPGLDTHGMRHPTANTIQRVFKMSFVPVGFWQRFIA 1033

  Fly   339 -------DNTPEIMEVVKKILQRQLNINIQNIKGETPLHIAIAR--RNVEMV---KLL------- 384
                   :...::.|..|....|...:.|.:..|......:..|  ||..:.   .||       
Human  1034 RMLISLAEMDLQLFENKKNTKSRNRKVTIYSFTGNQRNRCSTFRVKRNQTIYWQEGLLVTFDGGY 1098

  Fly   385 LKVPNIDINLRTYDEKCALELSLSMGDHEFLIASILLSMGAR---TDRTNS-------------K 433
            |.|.:.|:|.:          ....|..:.:..|.:....|.   ||..||             .
Human  1099 LSVESSDVNWK----------KKKSGGMKIVCQSEVRDFSAMAFITDHVNSLIDQWFPALTATES 1153

  Fly   434 TGDSLLQVF--------ALDRHR--GEKS------------------------------------ 452
            .|..|::.:        |..:|.  .|||                                    
Human  1154 DGTPLMEQYVPCPVCETAWAQHTDPSEKSEDVQYFDMEDCVLTAIERDFISCPRHPDLPVPLQEL 1218

  Fly   453 --AIFLADF--------ADLDHINFRGL--------TALHIAALNNMPNLVKKLIVN-------- 491
              .:|:.||        :.|:|....|.        |.::.|.....|..||:..:.        
Human  1219 VPELFMTDFPARLFLENSKLEHSEDEGSVLGQGGSGTVIYRARYQGQPVAVKRFHIKKFKNFANV 1283

  Fly   492 GASSNLKHIDCGLKSALHIAVEANAIDALEAFVELKNKS---HDIDFNC-QDINGDSPLSLCLSL 552
            .|.:.|:|:              .|.||::.|.|.:.::   |.:...| ..:.|.|...||.:|
Human  1284 PADTMLRHL--------------RATDAMKNFSEFRQEASMLHALQHPCIVALIGISIHPLCFAL 1334

  Fly   553 ----------------KRTTLVP-----------TLIRGGSDVNGKN-------KNNL------S 577
                            :.::.:|           .:..|.:.::.||       .:|:      .
Human  1335 ELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKKNIIFCDLKSDNILVWSLDV 1399

  Fly   578 PLHQSIKNEDSDISLFLLEQGADITALTENLDSALDLSIKHDLSEVVDALCRRGIALSINKNGES 642
            ..|.:||..|..||.....:||.....|... .|.::..:....|.|| :...|:.|....:|:.
Human  1400 KEHINIKLSDYGISRQSFHEGALGVEGTPGY-QAPEIRPRIVYDEKVD-MFSYGMVLYELLSGQR 1462

  Fly   643 P--------LWSALEKGYEDV----AKILVR--HGIDTDCWDEGPEGCRQTLLHRAIDENKE-SV 692
            |        :...|.||...|    .::..|  ..:..:|||..||  ::.|....:.:.|: :.
Human  1463 PALGHHQLQIAKKLSKGIRPVLGQPEEVQFRRLQALMMECWDTKPE--KRPLALSVVSQMKDPTF 1525

  Fly   693 AIFLIQSQCDLDSSRQPGPNGEGGDEAQDKASPLHLCCHWGQTKVLQTLIDHGANVNLI--DAES 755
            |.|:.:                             ||| ..||....:   .|....::  |.:.
Human  1526 ATFMYE-----------------------------LCC-GKQTAFFSS---QGQEYTVVFWDGKE 1557

  Fly   756 KSPLHVAIESQYDEIISILLCHPDIDLKLRDKSGNTPFATALDFRNH----------NAAQRILD 810
            :|..:..:.::...:....:|.|.:.:..:.:...:.:....|.:.:          |..|:.||
Human  1558 ESRNYTVVNTEKGLMEVQRMCCPGMKVSCQLQVQRSLWTATEDQKIYIYTLKGMCPLNTPQQALD 1622

  Fly   811 ---------RFPTAAEQMDIRGRNFLHLAILKDDLESVLFLLAIQVDVNSRVHDANQSSPLHLAA 866
                     ..|.      |:..::|.||.|.|.|.:|..:          |....:.|..:|.:
Human  1623 TPAVVTCFLAVPV------IKKNSYLVLAGLADGLVAVFPV----------VRGTPKDSCSYLCS 1671

  Fly   867 ASQNEMITRNLILAGARMNERDAVQKLPLHIAIERGNLPAVSALIQNNADYDATDADGNNALHIA 931
            .:.|.        :...:.:.||           |.|...|.|:...|:..:...::|...|  .
Human  1672 HTANR--------SKFSIADEDA-----------RQNPYPVKAMEVVNSGSEVWYSNGPGLL--V 1715

  Fly   932 VRCAQFFIVREL---LTESRVNAEATNLKGRNPLHELCRVVEDSTAGLIC--ELFLESMPKYPIN 991
            :.||...|.|.|   :..|.|.:...:.:||.  .|:...::|....|:.  ....:...:|...
Human  1716 IDCASLEICRRLEPYMAPSMVTSVVCSSEGRG--EEVVWCLDDKANSLVMYHSTTYQLCARYFCG 1778

  Fly   992 IPDMDGNTPLLLSFMRGQSPLCKILVKAGACLGTEN---KDGINI------FNFKLATDQLLHNL 1047
            :|     :||     |...|:..:..:..|...|.|   .:|.:|      ::.:|.|..|:|  
Human  1779 VP-----SPL-----RDMFPVRPLDTEPPAASHTANPKVPEGDSIADVSIMYSEELGTQILIH-- 1831

  Fly  1048 LDQLPQESPWAESDYCQHCTNRFTITMRKHHCRHCGRVLCSKCSCNDVP 1096
                 |||   .:|||.  .:.::.:..:...|....:..|..|.:.||
Human  1832 -----QES---LTDYCS--MSSYSSSPPRQAARSPSSLPSSPASSSSVP 1870

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG41099NP_001015359.1 BTB 67..164 CDD:279045 30/164 (18%)
BTB 75..166 CDD:197585 29/161 (18%)
ANK 252..385 CDD:238125 35/180 (19%)
ANK repeat 291..322 CDD:293786 7/37 (19%)
ANK repeat 325..362 CDD:293786 9/63 (14%)
Ank_2 330..431 CDD:289560 22/140 (16%)
ANK 463..595 CDD:238125 33/191 (17%)
ANK repeat 468..501 CDD:293786 9/48 (19%)
Ank_2 473..572 CDD:289560 21/137 (15%)
ANK repeat 503..539 CDD:293786 7/39 (18%)
ANK 536..660 CDD:238125 32/176 (18%)
ANK repeat 541..572 CDD:293786 7/57 (12%)
ANK repeat 574..637 CDD:293786 16/68 (24%)
Ank_2 579..670 CDD:289560 23/104 (22%)
ANK repeat 639..670 CDD:293786 8/44 (18%)
Ank_2 644..752 CDD:289560 20/116 (17%)
ANK repeat 672..721 CDD:293786 6/49 (12%)
ANK 721..843 CDD:238125 24/142 (17%)
ANK repeat 723..752 CDD:293786 6/30 (20%)
ANKYR 752..977 CDD:223738 42/246 (17%)
ANK repeat 754..786 CDD:293786 3/31 (10%)
ANK 820..944 CDD:238125 26/126 (21%)
ANK repeat 822..855 CDD:293786 8/32 (25%)
ANK repeat 857..888 CDD:293786 3/30 (10%)
ANK 885..1017 CDD:238125 27/136 (20%)
ANK repeat 890..921 CDD:293786 5/30 (17%)
ANK repeat 923..955 CDD:293786 9/34 (26%)
ANK repeat 996..1021 CDD:293786 4/24 (17%)
FYVE_ANFY1 1054..1116 CDD:277267 10/43 (23%)
LRRK1NP_078928.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 26..56
ANK 1 86..116
ANK 95..214 CDD:238125
ANK 2 119..148
Ank_2 126..221 CDD:289560
ANK 3 152..182
ANK repeat 156..186 CDD:293786
ANK repeat 188..218 CDD:293786
ANK 4 193..222
LRR_RI <214..488 CDD:238064
LRR 1 279..300
leucine-rich repeat 281..303 CDD:275380
LRR 302..614 CDD:227223
LRR 2 303..324
leucine-rich repeat 304..330 CDD:275380
LRR 3 330..351
leucine-rich repeat 331..353 CDD:275380
LRR 4 353..374
leucine-rich repeat 354..381 CDD:275380
LRR_RI 379..641 CDD:238064
LRR 5 381..402
leucine-rich repeat 382..405 CDD:275380
LRR 6 405..426
leucine-rich repeat 406..451 CDD:275380
LRR 7 427..447
LRR 8 451..472
leucine-rich repeat 452..474 CDD:275380
LRR 9 474..495
leucine-rich repeat 475..498 CDD:275380
LRR 10 498..519
leucine-rich repeat 499..549 CDD:275380
LRR 11 549..570
leucine-rich repeat 550..572 CDD:275380
LRR 12 572..594
LRR 13 596..617
Gem1 635..>781 CDD:224025 26/135 (19%)
P-loop_NTPase 639..821 CDD:304359 34/176 (19%)
COR 844..1036 CDD:292713 37/191 (19%)
S_TKc 1245..1511 CDD:214567 53/283 (19%)
STKc_LRRK1 1248..1523 CDD:270969 54/292 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1788..1810 4/21 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1841..1899 5/30 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0192
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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