DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG41099 and Ankrd42

DIOPT Version :9

Sequence 1:	NP_001015359.1	Gene:	CG41099 / 3355072	FlyBaseID:	FBgn0039955	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_082941.2	Gene:	Ankrd42 / 73845	MGIID:	1921095	Length:	516	Species:	Mus musculus

Alignment Length:	542	Identity:	115/542 - (21%)
Similarity:	189/542 - (34%)	Gaps:	181/542 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   563 RGGSDVNGKNKNNLSPLHQSIKNED----SDISLFLLEQGADITALTENLDSALDLSIKHDLSEV 623
            |..:|.:.:.|.:.|.:|.:::..|    |||    :|:||::..
Mouse    14 RETADSSSRKKVHFSSIHDAVRAGDVKQLSDI----VERGANLNE-------------------- 54

  Fly   624 VDALCRRGIALSINKNGESPL-WSALEKGYEDVAKILVRHGIDTDCWDEGPEGCRQTLLHRAIDE 687
            ||||           :..:|| |:|              |....:|            ||
Mouse    55 VDAL-----------HQFTPLHWAA--------------HSGSLEC------------LH----- 77

  Fly   688 NKESVAIFLIQSQCDLDSSRQPGPNGEGGDEAQDKASPLHLCCHWGQTKVLQTLIDHGANVNLID 752
                   :|:.|..|...:...|            .:..|:....||...||.||.:|||:...|
Mouse    78 -------WLLWSGADATQTTTRG------------WTAAHIAAIRGQDACLQALIINGANLATQD 123

  Fly   753 AESKSPLHVAIESQYDEIISILLCHPDIDLKLRDKSGNTPFATALDFRNHNAAQRILDRFPTAAE 817
            ....:|||:|....:...:.|:| ...:|..:.||....|...| .|.......::|.::....|
Mouse   124 DRGCTPLHLAATHGHSFSLQIML-RSGVDPSVTDKREWKPVHYA-SFHGRLGCLQLLVKWGCGIE 186

  Fly   818 QMDIRGRNFLHLAILKDDLESVLFLLAIQVDVNSRVHDANQSSPLHLAAASQN---------EMI 873
            .:|..|...:|||.::..|..:.|||       ||::.|.|:    |.|.:.|         ..:
Mouse   187 DVDYNGNLPVHLAAMEGHLHCLKFLL-------SRMNSATQA----LKAFNDNGENVLDLAQRFL 240

  Fly   874 TRNLI-------LAGARMNERDAVQKLPLHIAIERGNLPAVSALIQNNA-DYDATDADGNNALHI 930
            .:|::       ..|:..::.|.: ..|.|:|..:|:|..:..||.:.. :.:..|.:|:..:|.
Mouse   241 KQNVVEFIQGAQYEGSHPDDHDDL-AFPGHVAAFKGDLEVLKKLIGDGVINLNERDDNGSTPMHK 304

  Fly   931 A-----VRCAQFFIVRELLTESRVNAEATNLKGRNPLHELCRVVEDSTAGLICELFLESMPKYPI 990
            |     :.|.|:.|  |:..||.:    ||..|..|..     |....|.|.....||.:.||.|
Mouse   305 AAGQGHIDCLQWLI--EMGAESNI----TNKAGETPSD-----VAKRFAHLAAVKLLEGLQKYEI 358

  Fly   991 NIPDMDGNTPLLLSFMRGQSPLCKILVKAGACLGTENKDGINIFNFKLATDQLLHNLLDQLPQES 1055
            :..:.|                               ||.||.|.        .|.:     :.|
Mouse   359 DDIESD-------------------------------KDHINFFT--------RHGV-----EGS 379

  Fly  1056 PWAESDYCQHCTNRFTITMRKH 1077
            ..|:.|.|...:::....||.|
Mouse   380 TDAKDDLCLSESDKANARMRAH 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG41099	NP_001015359.1	BTB	67..164	CDD:279045
		BTB	75..166	CDD:197585
		ANK	252..385	CDD:238125
		ANK repeat	291..322	CDD:293786
		ANK repeat	325..362	CDD:293786
		Ank_2	330..431	CDD:289560
		ANK	463..595	CDD:238125	9/35 (26%)
		ANK repeat	468..501	CDD:293786
		Ank_2	473..572	CDD:289560	2/8 (25%)
		ANK repeat	503..539	CDD:293786
		ANK	536..660	CDD:238125	20/101 (20%)
		ANK repeat	541..572	CDD:293786	2/8 (25%)
		ANK repeat	574..637	CDD:293786	13/66 (20%)
		Ank_2	579..670	CDD:289560	18/95 (19%)
		ANK repeat	639..670	CDD:293786	6/31 (19%)
		Ank_2	644..752	CDD:289560	21/108 (19%)
		ANK repeat	672..721	CDD:293786	6/48 (13%)
		ANK	721..843	CDD:238125	32/121 (26%)
		ANK repeat	723..752	CDD:293786	10/28 (36%)
		ANKYR	752..977	CDD:223738	57/246 (23%)
		ANK repeat	754..786	CDD:293786	7/31 (23%)
		ANK	820..944	CDD:238125	34/145 (23%)
		ANK repeat	822..855	CDD:293786	10/32 (31%)
		ANK repeat	857..888	CDD:293786	6/46 (13%)
		ANK	885..1017	CDD:238125	31/137 (23%)
		ANK repeat	890..921	CDD:293786	7/31 (23%)
		ANK repeat	923..955	CDD:293786	9/36 (25%)
		ANK repeat	996..1021	CDD:293786	1/24 (4%)
		FYVE_ANFY1	1054..1116	CDD:277267	7/24 (29%)
Ankrd42	NP_082941.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27		3/12 (25%)
		ANK 1	25..54		9/32 (28%)
		Ank_4	26..80	CDD:290365	21/126 (17%)
		ANK	27..146	CDD:238125	41/203 (20%)
		ANK repeat	27..56	CDD:293786	9/52 (17%)
		ANK repeat	59..90	CDD:293786	11/68 (16%)
		ANK 2	59..88		11/66 (17%)
		Ank_2	64..156	CDD:289560	29/142 (20%)
		ANK repeat	92..123	CDD:293786	11/42 (26%)
		ANK 3	92..121		11/40 (28%)
		ANK	93..212	CDD:238125	33/132 (25%)
		ANK repeat	125..156	CDD:293786	7/31 (23%)
		ANK 4	125..154		7/29 (24%)
		ANK repeat	158..189	CDD:293786	5/31 (16%)
		ANK 5	158..187		4/29 (14%)
		Ank_4	159..212	CDD:290365	12/53 (23%)
		ANK	188..350	CDD:238125	43/184 (23%)
		ANK 6	191..220		11/35 (31%)
		Ank_2	197..328	CDD:289560	34/148 (23%)
		ANK 7	228..257		3/28 (11%)
		ANK 8	263..293		7/30 (23%)
		ANK repeat	297..328	CDD:293786	9/36 (25%)
		ANK 9	297..326		9/30 (30%)
		ANK 10	330..360		10/34 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1115202at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010