DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG41099 and ankrd28

DIOPT Version :9

Sequence 1:	NP_001015359.1	Gene:	CG41099 / 3355072	FlyBaseID:	FBgn0039955	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	XP_031760399.1	Gene:	ankrd28 / 734050	XenbaseID:	XB-GENE-5857499	Length:	1113	Species:	Xenopus tropicalis

Alignment Length:	1055	Identity:	237/1055 - (22%)
Similarity:	392/1055 - (37%)	Gaps:	270/1055 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   226 PLHAAVRLLREDVVSLCIQKYGNSLVNTFSENGILPLEMALSSKNAKIAKSLVDNGMANINAVNM 290
            |||.||....||.|.:.::...:  ||...:|...||.:|.::|..|.|::||.. ::|:|..:.
Frog   104 PLHRAVASCSEDAVQVLLKHSAD--VNARDKNWQTPLHIAAANKAVKCAEALVPL-LSNVNVSDR 165

  Fly   291 EGFSLLKSALKNGDAFSANFLLDQNC--------------------------------------- 316
            .|.:.|..|..:|.....:.||.:..
Frog   166 AGRTALHHAAFSGHVEMVSLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVTHGAEVMCKD 230

  Fly   317 ---------------------LLDL-----PSKPSSDTALHIICNYGPDNTPEIMEVVKKILQRQ 355
                                 ||||     .|....:|.||:.|..|.|      .||.:::...
Frog   231 KKSYTPLHAAASSGMISVIKYLLDLGVDMNESNAYGNTPLHVACYNGQD------VVVNELIDCG 289

  Fly   356 LNINIQNIKGETPLHIAIARRNVEMVKLLLKVPNIDINLRTYDEKCALELSLSMGDHEFLIASIL 420
            .|:|..|.:|.||||.|.|..:..:...||.....|:|:::.|.|..|.::...|  .|..:.|:
Frog   290 ANVNQVNERGFTPLHFAAASTHGALCLELLVCNGADVNIKSKDGKTPLHMTAIHG--RFSRSQII 352

  Fly   421 LSMGARTDRTNSKTGDSLLQVFALDRHRGEKSAI--FLADFADLDHINFRGLTALHIAALNNMPN 483
            :..||..| ...|.|::.|.:.|   ..|.:..|  .:...||.......|:..||:|||:...:
Frog   353 IQNGAEID-CEDKNGNTPLHIAA---RYGHELLINTLITSRADTSKRGIHGMFPLHLAALSGFSD 413

  Fly   484 LVKKLIVNGASSNLKHIDCGLKSALHIAVEANAIDALEAFVELKNKSHDIDFNCQDINGDSPLSL 548
            ..:||:.:|...: .|.|.| ::.||.|.....::.|...:     |...|||.:|..|.:||..
Frog   414 CCRKLLSSGFDID-THDDFG-RTCLHAAAAGGNLECLNLLL-----STGADFNKKDKFGRTPLHY 471

  Fly   549 CLSLKRTTLVPTLIRGGSDVNGKNKNNLSPLHQSIKNEDSD------------------------ 589
            ..:......:..|:..|:.||..::...||||.: ...|:|
Frog   472 AAANCNYQCLFALVGSGASVNDLDERGCSPLHYA-ATSDTDGKCLEYLLRNDANPGIRDKHGYNA 535

  Fly   590 ------------ISLFLLEQGADITALTENLD-----------SALDLSIKHDLSEVVDALCRRG 631
                        :.|...|...|:...|...|           |.|.|:..|...:.::.|.:..
Frog   536 VHYAAAYGHRLCLELIARETPLDVLMETSGTDMLNDAETRAPISPLHLAAYHGHHQALEVLVQSL 600

  Fly   632 IALSI-NKNGESPLWSALEKGYEDVAKILVRHGI------------------------------- 664
            :.|.: |..|.:||..|..||:.:...:|:..|.
Frog   601 LDLDVRNSTGRTPLDLAAFKGHVECVDVLINQGASILVKDYVVKRTPIHSAEIQMVDSRNSVNKN 665

  Fly   665 DTDCWDEGPEGCRQTLLHRAIDENKESVAIFL----IQSQCDLDSSRQPGP------NG------ 713
            :|:..:...:..|...:..||:.:.|.:.:.:    :|:..|:.......|      ||
Frog   666 NTELCNSAQKKVRAKDMPSAINGHSECLRLLIGNADVQAAVDIHDGNGQTPLMLSVLNGHTECVY 730

  Fly   714 ----EGGD-EAQDK--ASPLHLCCHWGQTKVLQTLIDHGANVNLIDAESKSPLHVAIESQYDEII 771
                :|.: :|:||  .:.||.....|..:.::.|:.|.||..|.|...::|:|:|....:..::
Frog   731 SLLNKGANVDAKDKWGRTALHRGAVTGHEECVEALLQHNANFLLRDCRGRTPIHLAAACGHIGVL 795

  Fly   772 SILL---CHPDIDLKLRDKSGNTPFATALDFRNHNAAQRILDRFPTAAEQ---MDIRGRNF--LH 828
            |.||   ...|:...:.|..|.||...|. :..|:|...:|      .||   ..:.|.:|  ||
Frog   796 SALLQTAISVDVVPAIADNHGYTPLHWAC-YNGHDACVELL------LEQEVFQKMEGNSFSPLH 853

  Fly   829 LAILKDD---LESVLFLLAIQVDVNSRVHDANQSSPLHLAAASQNEMITRNLILAGARMNERDAV 890
            .|::.|:   .|.::..|...: |||  .|:...:|||.||.:.:....:.|:...|::|..|:.
Frog   854 CAVINDNEGAAEMLIDTLGTSI-VNS--VDSKGRTPLHAAAFTDHIECLQLLLSHNAQVNAVDST 915

  Fly   891 QKLPLHIAIERGNLPAVSALIQN-NADYDATDADGNNALHIAVRCAQ------FFIVRELLTESR 948
            .|.||.:|.|.|...||..|:.: .||....|.:.|.|||:|  |::      ..|:.::...:.
Frog   916 GKTPLMMAAENGQTSAVEVLVSSAKADLTLQDKNKNTALHLA--CSKGHETSALLILEQITDRNL 978

  Fly   949 VNAEATNLKGRNPLHELCRVVEDSTAGLICELFLESMPKYPINIPDMDGNTPLLLSFMRGQSPLC 1013
            :|  |||...:.|||...|   :....::.||..:......:   |.:|.||.|
Frog   979 IN--ATNSALQTPLHVAAR---NGLTVVVQELLGKGASVLAV---DENGYTPAL----------- 1024

  Fly  1014 KILVKAGACLGTENKDGINIFNFKLATDQLLHNLLDQLPQESPWAESDYCQHCTNRF-----TIT 1073
                   ||  ..|||..:.....|||         .:|..|..:......:..|.:     |:|
Frog  1025 -------AC--APNKDVADCLALILAT---------MMPVSSSSSLPSMTLNAINHYNNTSKTVT 1071

  Fly  1074 ------MRKHHCRHC 1082
                  ||..|..:|
Frog  1072 FDTLPVMRSEHSSYC 1086

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG41099	NP_001015359.1	BTB	67..164	CDD:279045
		BTB	75..166	CDD:197585
		ANK	252..385	CDD:238125	41/197 (21%)
		ANK repeat	291..322	CDD:293786	10/95 (11%)
		ANK repeat	325..362	CDD:293786	10/36 (28%)
		Ank_2	330..431	CDD:289560	30/100 (30%)
		ANK	463..595	CDD:238125	35/167 (21%)
		ANK repeat	468..501	CDD:293786	10/32 (31%)
		Ank_2	473..572	CDD:289560	27/98 (28%)
		ANK repeat	503..539	CDD:293786	9/35 (26%)
		ANK	536..660	CDD:238125	33/171 (19%)
		ANK repeat	541..572	CDD:293786	7/30 (23%)
		ANK repeat	574..637	CDD:293786	17/110 (15%)
		Ank_2	579..670	CDD:289560	25/169 (15%)
		ANK repeat	639..670	CDD:293786	9/61 (15%)
		Ank_2	644..752	CDD:289560	28/161 (17%)
		ANK repeat	672..721	CDD:293786	11/69 (16%)
		ANK	721..843	CDD:238125	35/134 (26%)
		ANK repeat	723..752	CDD:293786	8/28 (29%)
		ANKYR	752..977	CDD:223738	66/242 (27%)
		ANK repeat	754..786	CDD:293786	7/34 (21%)
		ANK	820..944	CDD:238125	40/135 (30%)
		ANK repeat	822..855	CDD:293786	11/37 (30%)
		ANK repeat	857..888	CDD:293786	8/30 (27%)
		ANK	885..1017	CDD:238125	36/138 (26%)
		ANK repeat	890..921	CDD:293786	11/31 (35%)
		ANK repeat	923..955	CDD:293786	9/37 (24%)
		ANK repeat	996..1021	CDD:293786	4/24 (17%)
		FYVE_ANFY1	1054..1116	CDD:277267	8/40 (20%)
ankrd28	XP_031760399.1	ANK repeat	38..65	CDD:293786
		PHA03095	49..>337	CDD:222980	56/241 (23%)
		ANK repeat	67..98	CDD:293786
		ANK repeat	103..131	CDD:293786	10/28 (36%)
		ANK repeat	133..164	CDD:293786	11/31 (35%)
		ANK repeat	167..197	CDD:293786	6/29 (21%)
		ANK repeat	199..230	CDD:293786	0/30 (0%)
		ANK repeat	232..263	CDD:293786	4/30 (13%)
		PHA03095	246..>532	CDD:222980	78/305 (26%)
		ANK repeat	265..296	CDD:293786	10/36 (28%)
		ANK repeat	298..329	CDD:293786	11/30 (37%)
		ANK repeat	332..363	CDD:293786	9/33 (27%)
		ANK repeat	365..395	CDD:293786	7/32 (22%)
		ANK repeat	402..429	CDD:293786	8/27 (30%)
		Ank_2	416..>651	CDD:423045	48/242 (20%)
		ANK repeat	431..462	CDD:293786	9/36 (25%)
		ANK repeat	464..495	CDD:293786	7/30 (23%)
		ANK repeat	497..529	CDD:293786	6/32 (19%)
		ANK repeat	531..561	CDD:293786	3/29 (10%)
		ANK repeat	563..607	CDD:293786	8/43 (19%)
		ANK repeat	609..640	CDD:293786	8/30 (27%)
		PHA03095	694..>1023	CDD:222980	88/348 (25%)
		ANK repeat	712..743	CDD:293786	5/30 (17%)
		ANK repeat	745..776	CDD:293786	8/30 (27%)
		ANK repeat	882..913	CDD:293786	8/30 (27%)
		ANK repeat	915..947	CDD:293786	11/31 (35%)
		ANK repeat	949..1016	CDD:293786	17/76 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1115202at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010