DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG41099 and Lrrk2

DIOPT Version :9

Sequence 1:	NP_001015359.1	Gene:	CG41099 / 3355072	FlyBaseID:	FBgn0039955	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_080006.3	Gene:	Lrrk2 / 66725	MGIID:	1913975	Length:	2527	Species:	Mus musculus

Alignment Length:	944	Identity:	171/944 - (18%)
Similarity:	302/944 - (31%)	Gaps:	329/944 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   239 VSLCIQKYGNSLVNTFSENGILPLEMALSSKNAKIAKSLVDNGMANINAVNMEGFSLLKSALKNG 303
            :...:|...:.||.|:|:..    ......||..:...:|.:....:.:|...|:|||
Mouse    34 IETLLQLLEDMLVFTYSDRA----SKLFEDKNFHVPLLIVLDSYMRVASVQQAGWSLL------- 87

  Fly   304 DAFSANFLLDQNCLLDLPSKPSSDTALHIICNYGPDNTPEIMEV--VKKILQRQLNINIQNIKGE 366
                        |.| :...|.:..:|     .||.:.....||  :.:::.:.|.::..|:
Mouse    88 ------------CKL-IEVCPGTLQSL-----IGPQDIGNDWEVLGIHRLILKMLTVHHANV--- 131

  Fly   367 TPLHIAIARRNVEMVKLLLKVPNIDINLRTYDEKCALELSLSMGDHEFLIASILLSMGAR----- 426
               :::|    |.:..|.|.:.:..:.|...||:|.:.|.:....|.:.....:..:|.:
Mouse   132 ---NLSI----VGLKALDLLLDSGKLTLLILDEECDIFLLIFDAMHRYSANDEVQKLGCKALHVL 189

  Fly   427 ---------TDRTNSKTGDSLLQVFALDRHRGEKSAIFLADFADLDHINFRGLTALHIAAL--NN 480
                     |:...:|....||..|.  ..|.:|..::        |:    |..||..|:  :|
Mouse   190 FERVSEEQLTEFVENKDYTILLSTFG--SFRRDKEIVY--------HV----LCCLHSLAVTCSN 240

  Fly   481 MPNLVK------KLIVNG-----ASSNLKHIDCGLKSAL--------------HI---------- 510
            :..|:.      .|:|..     .:.|::.:.|.|...|              |:
Mouse   241 VEVLMSGNVRCYNLVVEAMKAFPTNENIQEVSCSLFQKLTLGNFFNILVLNEVHVFVVKAVRQYP 305

  Fly   511 ---AVEANAIDALEAFVELKNKSHDIDFNC----QDINGDSPLSLCLSLKRTTLVP---TLIRGG 565
               |::.:|:..|....|....:.|::...    |....||.       |...|.|   .|:|..
Mouse   306 ENAALQISALSCLALLTETIFLNQDLEERSETQEQSEEEDSE-------KLFWLEPCYKALVRHR 363

  Fly   566 SDVNGKNK-----NNL----SPLHQSIKNEDSDISLFLLEQGADITALTENLDSALDLSIKHDLS 621
            .|.:.:..     |||    :.||:.|.:||..   |...:...::.|..:....:..:..|.||
Mouse   364 KDKHVQEAACWALNNLLMYQNSLHEKIGDEDGQ---FPAHREVMLSMLMHSSSKDVFQAAAHALS 425

  Fly   622 EVVDALCRRGIALSINKNGESPLWSALEKG-YEDVAKILVRHGIDTDCWDEGPE----GCRQTLL 681
            .:::.          |.|....|   |.|| |.:|.:::.:|.       ..||    ||:. |.
Mouse   426 TLLEQ----------NVNFRKIL---LAKGVYLNVLELMQKHA-------HAPEVAESGCKM-LS 469

  Fly   682 HRAIDENKESVAIFLIQSQCDLDSSRQPGPNGEGGDEAQDKASPLHLCCHWGQTKVLQTLIDHGA 746
            |           :|                  ||.:.:.|..:.:       ..|:|..:..||.
Mouse   470 H-----------LF------------------EGSNPSLDTMAAV-------VPKILTVMKAHGT 498

  Fly   747 NVNLIDAESKSPLHVAIESQYDEIISILLCHPDIDLKLRDKSGNTPFATALDFRNHNAAQRILDR 811
            ::::.....::.||..:....:|......|.|::   ||.:...|..        |......|:|
Mouse   499 SLSVQLEALRAILHFVVPGLLEESREDSQCRPNV---LRKQCFRTDI--------HKLVLVALNR 552

  Fly   812 F--------------------PTAAEQMDIRGRNFLHLAILKDDLESVLFLLAIQVDVNSRVHDA 856
            |                    |.|.|.:.::|.           ::|||..|.:..|     ...
Mouse   553 FIGNPGIQKCGLKVISSLAHLPDATETLSLQGA-----------VDSVLHTLQMYPD-----DQE 601

  Fly   857 NQSSPLHLAAASQNEMITRNL----------ILAGARMNERDAVQ-------------------- 891
            .|...|||....   |..:|.          |||......:|..:
Mouse   602 IQCLGLHLMGCL---MTKKNFCIGTGHLLAKILASTLQRFKDVAEVQTTGLQTTLSILELSVSFS 663

  Fly   892 KLPLHIAIERGNLPAVSALIQNNADYD------------ATD-----------ADGNNALHIAVR 933
            ||.:|.:.:......:|:.:....|..            |.|           .|.||:  |.|.
Mouse   664 KLLVHYSFDVVIFHQMSSSVVEQKDEQFLNLCCKCFAKVAVDDELKNTMLERACDQNNS--IMVE 726

  Fly   934 CAQFFIVRELLTESRVNAEATNLKGRNPLHELCRVVEDSTAGLICELFLESMPKYPINIPDMDGN 998
            |        ||.   :.|:|..:||...|  :.:|.|..::..:.||.|..      ...:.|..
Mouse   727 C--------LLL---LGADANQVKGATSL--IYQVCEKESSPKLVELLLNG------GCREQDVR 772

  Fly   999 TPLLLSFMRGQSPLCKILVKAGA--------CLG 1024
            ..|.:|..:|.|.:..:|::..|        |||
Mouse   773 KALTVSIQKGDSQVISLLLRKLALDLANNSICLG 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG41099	NP_001015359.1	BTB	67..164	CDD:279045
		BTB	75..166	CDD:197585
		ANK	252..385	CDD:238125	23/134 (17%)
		ANK repeat	291..322	CDD:293786	6/30 (20%)
		ANK repeat	325..362	CDD:293786	6/38 (16%)
		Ank_2	330..431	CDD:289560	19/116 (16%)
		ANK	463..595	CDD:238125	37/187 (20%)
		ANK repeat	468..501	CDD:293786	9/45 (20%)
		Ank_2	473..572	CDD:289560	26/145 (18%)
		ANK repeat	503..539	CDD:293786	8/66 (12%)
		ANK	536..660	CDD:238125	30/140 (21%)
		ANK repeat	541..572	CDD:293786	8/33 (24%)
		ANK repeat	574..637	CDD:293786	13/66 (20%)
		Ank_2	579..670	CDD:289560	19/91 (21%)
		ANK repeat	639..670	CDD:293786	8/31 (26%)
		Ank_2	644..752	CDD:289560	21/112 (19%)
		ANK repeat	672..721	CDD:293786	9/52 (17%)
		ANK	721..843	CDD:238125	24/141 (17%)
		ANK repeat	723..752	CDD:293786	4/28 (14%)
		ANKYR	752..977	CDD:223738	53/297 (18%)
		ANK repeat	754..786	CDD:293786	6/31 (19%)
		ANK	820..944	CDD:238125	29/176 (16%)
		ANK repeat	822..855	CDD:293786	6/32 (19%)
		ANK repeat	857..888	CDD:293786	9/40 (23%)
		ANK	885..1017	CDD:238125	31/174 (18%)
		ANK repeat	890..921	CDD:293786	6/62 (10%)
		ANK repeat	923..955	CDD:293786	10/31 (32%)
		ANK repeat	996..1021	CDD:293786	6/24 (25%)
		FYVE_ANFY1	1054..1116	CDD:277267
Lrrk2	NP_080006.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	957..979
		LRR 1	983..1004
		leucine-rich repeat	985..1012	CDD:275380
		LRR 2	1012..1033
		leucine-rich repeat	1013..1036	CDD:275380
		LRR 3	1036..1057
		leucine-rich repeat	1037..1059	CDD:275380
		LRR 4	1059..1080
		leucine-rich repeat	1060..1084	CDD:275380
		LRR 5	1084..1105
		leucine-rich repeat	1085..1108	CDD:275380
		LRR 6	1108..1129
		leucine-rich repeat	1109..1130	CDD:275380
		LRR 7	1130..1151
		leucine-rich repeat	1131..1170	CDD:275380
		leucine-rich repeat	1171..1197	CDD:275380
		LRR 8	1174..1195
		LRR 9	1197..1218
		leucine-rich repeat	1198..1221	CDD:275380
		LRR 10	1221..1242
		leucine-rich repeat	1222..1246	CDD:275380
		LRR 11	1246..1267
		LRR 12	1269..1291
		leucine-rich repeat	1270..1291	CDD:275380
		Gem1	1333..1551	CDD:224025
		RocCOR	1334..1507	CDD:206741
		COR	1527..1740	CDD:292713
		STKc_LRRK2	1884..2135	CDD:270970
		S_TKc	1884..2128	CDD:214567
		WD 1	2139..2183
		WD 2	2188..2228
		WD 3	2233..2276
		WD 4	2281..2327
		WD 5	2333..2377
		WD 6	2402..2438
		WD 7	2443..2497
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900