DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG41099 and Map3k20

DIOPT Version :9

Sequence 1:	NP_001015359.1	Gene:	CG41099 / 3355072	FlyBaseID:	FBgn0039955	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_075544.1	Gene:	Map3k20 / 65964	MGIID:	2443258	Length:	802	Species:	Mus musculus

Alignment Length:	702	Identity:	141/702 - (20%)
Similarity:	229/702 - (32%)	Gaps:	275/702 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 LLGICERALVTSV-GVRSCIRFY----------CVAEEVGASTLLEYCSSIISTHWD-----DLT 203
            ||.|.:.|.:.|| ..|:.|:||          .|.|.....:|.:|.:|..|...|     ...
Mouse    47 LLKIEKEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMEHIMTWA 111

  Fly   204 TD-----DFQHMSGPLLFEMLKTKTKHPLHAAVRLLREDVVSLC---IQKYGN-----SLVNTF- 254
            ||     .:.||..|:.......|:::.:.||     :.|:.:|   ..::.|     |||.||
Mouse   112 TDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAA-----DGVLKICDFGASRFHNHTTHMSLVGTFP 171

  Fly   255 ------------SEN------GILPLEMALSSKNAKIAKSLVDNGMANINAVNMEGFSLLKSALK 301
                        ||.      |::..||        :.:.:...|        :||..:....::
Mouse   172 WMAPEVIQSLPVSETCDTYSYGVVLWEM--------LTREVPFKG--------LEGLQVAWLVVE 220

  Fly   302 NGDAFS------ANF--LLDQNCLLDLPSKP------------SSDTALHIICNYGPDNTPE--- 343
            ..:..:      .:|  ||.|....|...:|            |:||.|...||....|..|
Mouse   221 KNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESMSNDTNLPDQCNSFLHNKAEWRC 285

  Fly   344 ----IMEVVKKILQRQLNINIQNIKGETPLHIAIARRNVEMVKLLLKVPNIDINLRTYDEKCALE 404
                .:|.:|| |:|.|:...|.:|..       .||                 |:.:::|
Mouse   286 EIEATLERLKK-LERDLSFKEQELKER-------ERR-----------------LKMWEQK---- 321

  Fly   405 LSLSMGDHEFLIASILLSMGARTDRTNSKTGDSLLQVFALDRHRGEKSAIFLADFADLDHINFRG 469
              |:...:..|:.|  ..:||.|:      .|....|..|.| :|| |::.::.:|.|...|
Mouse   322 --LTEQSNTPLLPS--FEIGAWTE------DDVYFWVQQLVR-KGE-SSVEMSGYASLFKEN--- 371

  Fly   470 LTALHIAALNNMPNLVKKLIVNGASSNLKHIDCGLKSALHIAVEANAIDALEAFVELKNKSHDID 534
                         |:..|.::.....:||  |.|:.|..||....:||:.|         :||.
Mouse   372 -------------NITGKRLLLLEEEDLK--DMGIVSKGHIIHFKSAIEKL---------THDY- 411

  Fly   535 FNCQDINGDSPLSLCLSLKRTTLVPTLIRGGSDVNGKNKNNLSPLHQSIKNEDSDISLFL----- 594
                           |:|..   .|.||:   |..|:.:          :||:..::|.|
Mouse   412 ---------------LNLFH---FPPLIK---DSGGEPE----------ENEEKIVNLELVFGFH 445

  Fly   595 ---------------LEQGADITALTENLDSALDLSIKHDLSEVVDALCRRGIALSINKNGESPL 644
                           :|...|..|:|...|...:.|:.       ||        .|.|..:.|.
Mouse   446 LKPGTGPQDCKWKMYMEMDGDEVAITYIKDVTFNTSLP-------DA--------EILKMTKPPF 495

  Fly   645 WSALEK---------------GYEDVAKI--LVRHGIDTDCWDEGPEGCRQTLLHRAIDENKESV 692
              .:||               .||:..:.  |.:| :.:..||            |...:::...
Mouse   496 --VMEKWIVGIAEDQTVECTVTYENDVRTPKLTKH-VHSIQWD------------RTKPQDEVKA 545

  Fly   693 AIFLIQSQCDLDSSRQPGPNGEGGDEAQDKASPLHLCCHWGQTKVLQTLIDH 744
            ....||:   |.||.:..| |...|.:.|        |.|..|..::.:..|
Mouse   546 VQLAIQT---LFSSSEGNP-GSRSDSSAD--------CQWLDTLRMRQIASH 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG41099	NP_001015359.1	BTB	67..164	CDD:279045	4/8 (50%)
		BTB	75..166	CDD:197585	4/10 (40%)
		ANK	252..385	CDD:238125	34/178 (19%)
		ANK repeat	291..322	CDD:293786	7/38 (18%)
		ANK repeat	325..362	CDD:293786	14/43 (33%)
		Ank_2	330..431	CDD:289560	23/107 (21%)
		ANK	463..595	CDD:238125	26/151 (17%)
		ANK repeat	468..501	CDD:293786	4/32 (13%)
		Ank_2	473..572	CDD:289560	21/98 (21%)
		ANK repeat	503..539	CDD:293786	9/35 (26%)
		ANK	536..660	CDD:238125	26/160 (16%)
		ANK repeat	541..572	CDD:293786	7/30 (23%)
		ANK repeat	574..637	CDD:293786	12/82 (15%)
		Ank_2	579..670	CDD:289560	21/127 (17%)
		ANK repeat	639..670	CDD:293786	7/47 (15%)
		Ank_2	644..752	CDD:289560	22/118 (19%)
		ANK repeat	672..721	CDD:293786	9/48 (19%)
		ANK	721..843	CDD:238125	5/24 (21%)
		ANK repeat	723..752	CDD:293786	4/22 (18%)
		ANKYR	752..977	CDD:223738
		ANK repeat	754..786	CDD:293786
		ANK	820..944	CDD:238125
		ANK repeat	822..855	CDD:293786
		ANK repeat	857..888	CDD:293786
		ANK	885..1017	CDD:238125
		ANK repeat	890..921	CDD:293786
		ANK repeat	923..955	CDD:293786
		ANK repeat	996..1021	CDD:293786
		FYVE_ANFY1	1054..1116	CDD:277267
Map3k20	NP_075544.1	STKc_MLTK	22..263	CDD:270962	47/236 (20%)
		Leucine-zipper	287..308		7/21 (33%)
		SAM_MLTK	338..408	CDD:188928	24/104 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	624..802
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900