DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG41099 and Ripk3

DIOPT Version :9

Sequence 1:	NP_001015359.1	Gene:	CG41099 / 3355072	FlyBaseID:	FBgn0039955	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_064339.2	Gene:	Ripk3 / 56532	MGIID:	2154952	Length:	486	Species:	Mus musculus

Alignment Length:	273	Identity:	57/273 - (20%)
Similarity:	92/273 - (33%)	Gaps:	97/273 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 SQTRVFP--AHKIVLHARSE--------KWGNDLLSNIQQLDWSDLNEDVVLSL-----LRWIYT 129
            |..:::|  |..:.|.:|.|        |.|..::.......|   |.||.:.:     :.|...
Mouse     2 SSVKLWPTGASAVPLVSREELKKLEFVGKGGFGVVFRAHHRTW---NHDVAVKIVNSKKISWEVK 63

  Fly   130 DLIDLQNDGLALDLLKAAHRFGLPSLLGICE---------RALVTSVGVRSCIRFYCVAEEVGAS 185
            .:::|:|:.:.|             |||:.|         :||||        ||
Mouse    64 AMVNLRNENVLL-------------LLGVTEDLQWDFVSGQALVT--------RF---------- 97

  Fly   186 TLLEYCSSIISTHWDDLTTDDFQHMSGPLLFEMLKTKTKHPLHAAVRLLREDVVSLCIQKYGNSL 250
                                    |....|..:|:.:...|.....|||:|.|:.:|   |.:||
Mouse    98 ------------------------MENGSLAGLLQPECPRPWPLLCRLLQEVVLGMC---YLHSL 135

  Fly   251 VNTFSENGILPLEMALSSK-NAKIAKSLVDNGMANINAVNMEGFSLLKSALKNGDAFSANFL--L 312
            ........:.|..:.|..: :||:|    |.|::.....:..|     |...:|...|...|  |
Mouse   136 NPPLLHRDLKPSNILLDPELHAKLA----DFGLSTFQGGSQSG-----SGSGSGSRDSGGTLAYL 191

  Fly   313 DQNCLLDLPSKPS 325
            |...|.|:..|.|
Mouse   192 DPELLFDVNLKAS 204

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG41099	NP_001015359.1	BTB	67..164	CDD:279045	21/107 (20%)
		BTB	75..166	CDD:197585	23/109 (21%)
		ANK	252..385	CDD:238125	18/77 (23%)
		ANK repeat	291..322	CDD:293786	9/32 (28%)
		ANK repeat	325..362	CDD:293786	1/1 (100%)
		Ank_2	330..431	CDD:289560
		ANK	463..595	CDD:238125
		ANK repeat	468..501	CDD:293786
		Ank_2	473..572	CDD:289560
		ANK repeat	503..539	CDD:293786
		ANK	536..660	CDD:238125
		ANK repeat	541..572	CDD:293786
		ANK repeat	574..637	CDD:293786
		Ank_2	579..670	CDD:289560
		ANK repeat	639..670	CDD:293786
		Ank_2	644..752	CDD:289560
		ANK repeat	672..721	CDD:293786
		ANK	721..843	CDD:238125
		ANK repeat	723..752	CDD:293786
		ANKYR	752..977	CDD:223738
		ANK repeat	754..786	CDD:293786
		ANK	820..944	CDD:238125
		ANK repeat	822..855	CDD:293786
		ANK repeat	857..888	CDD:293786
		ANK	885..1017	CDD:238125
		ANK repeat	890..921	CDD:293786
		ANK repeat	923..955	CDD:293786
		ANK repeat	996..1021	CDD:293786
		FYVE_ANFY1	1054..1116	CDD:277267
Ripk3	NP_064339.2	Pkinase	24..284	CDD:278497	51/251 (20%)
		PKc_like	28..284	CDD:304357	51/247 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	312..333
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	349..388
		RHIM	410..457	CDD:289491
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269\|PubMed:18442983	440..461
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	462..486
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900