DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG41099 and ankhd1

DIOPT Version :9

Sequence 1:	NP_001015359.1	Gene:	CG41099 / 3355072	FlyBaseID:	FBgn0039955	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	XP_009293757.1	Gene:	ankhd1 / 563327	ZFINID:	ZDB-GENE-090421-1	Length:	2607	Species:	Danio rerio

Alignment Length:	1100	Identity:	237/1100 - (21%)
Similarity:	374/1100 - (34%)	Gaps:	358/1100 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 DVVSLCIQKYGNSLVNTFSENGILPLEMALSSKNAKIAKSLVDNGMANINA-------------- 287
            |||.:.:::..|  :...:|||..||..|.|:.:.::|:.|::.| |.||.
Zfish   314 DVVKVLLKEGAN--IEDHNENGHTPLMEAASAGHVEVARVLLEYG-AGINTHSNEFKESALTLAC 375

  Fly   288 ----VNMEGFSL----------------LKSALKNGDAFSANFLLDQNCLLDLPSKPSSDTALHI 332
                ::|..|.|                |..|..:|....|..|||....:::|: .|.::.|.:
Zfish   376 YKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPA-DSFESPLTL 439

  Fly   333 ICNYGPDNTPEIMEVVKKILQRQLNINIQNIKGETPLHIAIARRNVEMVKLLLKVPNIDINLRTY 397
            ....|.      :|:...:::|..|:...|.:|.|||..|....:.|||.||| ....:||.:|.
Zfish   440 AACGGH------VELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLL-AQGANINAQTE 497

  Fly   398 D-EKCALELSLSMGDHE---FLI-------------------------ASILLSMGARTDRTNSK 433
            : ::.||.|:...|..|   |||                         ...||:.||....|.:
Zfish   498 ETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTA- 561

  Fly   434 TGDSLLQVFALDRHRGEKSAIFLADFADLDHINFRGLTALHIAALNNMPNLVKKLI-----VNGA 493
            |||:.| .:|.:....:.:.:.|...|||:|.:..|.|.|..||.......|:.||     ||.|
Zfish   562 TGDTAL-TYACENGHTDVADVLLQTGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRA 625

  Fly   494 SSNLKH----IDCG--------------------LKSALHIAVEA----------------NAID 518
            ::|..|    :.|.                    ||....:.:||                |.|.
Zfish   626 TANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNIL 690

  Fly   519 ALEA--FVELKNKSHD------IDFNCQDINGDSPLSLCLSLKRTTLVPTLIRGGSDV--NGKNK 573
            ::.|  ..:|...|||      :.|..        |::.:..:....||:.|.....|  .|.:|
Zfish   691 SVPAPDLSQLTPPSHDTSQAPRVPFQA--------LAMVVPPQEPDRVPSTIPTPPPVTSKGASK 747

  Fly   574 NNLSPLH-QSIKNEDSDISLF-------------------LLEQGADITALTENLDSALDL---- 614
            ..||.|. .|:.:...|..|.                   |.|.|..|:|:.:....:|:|
Zfish   748 QRLSSLQSNSVASGGLDADLLPPFHPYQPLECIVEETEGKLNELGQRISAIEKAQLQSLELIQGE 812

  Fly   615 --------SIKHDLSEVVDALCRRGIALSINK-------------NGESPLWSALEKGYEDVAKI 658
                    .:|....|.|..  ::.|...:.|             ..|......|::.....|.:
Zfish   813 PLTKDKIEELKKSREEQVQK--KKKILKELQKVERQLQLKTQQQFTKEYMETKGLKEELGQAAGV 875

  Fly   659 ----------LVRHGIDTDCWDEGPEGCRQTLLHRAIDENKES---------------------- 691
                      ..:.|.|.:|     ||..:...||....|:|.
Zfish   876 EMPGTPLPLQATQLGSDNEC-----EGIHEKEDHRPTPTNEEDEDEEEDEDDIDCAKLPQVNTIL 935

  Fly   692 ----------------------VAIFLIQSQCDLDSSRQPGPNGEGGD----------------- 717
                                  |.|..:..|...|.|....|.....|
Zfish   936 QPPPPPPPQNQVLQSPPLQTSFVPIQPLTPQLSTDFSSAEYPGSSSPDLQRVLLGQPLTGLGPGL 1000

  Fly   718 --EAQD---KASPLHLCCHWGQTKVLQTLIDHGANVNL--------------------------- 750
              :|.|   .|:|       .|| :..||.|..|.||.
Zfish  1001 LAQASDGLMVATP-------AQT-LTDTLDDIMAAVNSRVPVVNTTTSPSPQPSAQTPINTASPP 1057

  Fly   751 ----------IDAESKS----PLHVAIESQYDEIISILLCHPDIDLKLRDKSGNTPFATALDFRN 801
                      |||.::|    .|.:|....::|::|:|:.. ..:::.|||.|.||...|....:
Zfish  1058 SMLPLYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIAR-GANIEHRDKKGFTPLILAATAGH 1121

  Fly   802 HNAAQRILDRFPTAAEQMDIRGRNFLHLAILKDDLESVLFLLAIQVDVNSRVHDANQSSPLHLAA 866
            ....:.:||:......|.:......|.|| .....:.|:.||.:: ..|....:.:..:||.|||
Zfish  1122 VGVVEILLDKGGDIEAQSERTKDTPLSLA-CSGGRQEVVELLLLR-GANKEHRNVSDYTPLSLAA 1184

  Fly   867 ASQNEMITRNLILAGARMNERDAVQKL---PLHIAIERGNLPAVSALIQNNADYDA-TDADGNNA 927
            :.....|.:.|:.|||.:|.|.. .||   ||.:|...|::|||..|:...:|.:| .:.:.|.|
Zfish  1185 SGGYVNIIKILLNAGAEINSRTG-SKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTA 1248

  Fly   928 LHIAVRCAQFFIVRELLTESRVNAEATNLKGRNPLHELC--------RVVEDSTAGL-------- 976
            |.:|....:..:| .||.:.:.|.|.....|..||.|..        ||:.|..|.:
Zfish  1249 LTLACFQGRAEVV-SLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSS 1312

  Fly   977 ---------------ICELFLESMPKYPINIPDMDGNTPLLLSFMRGQSPLCKILVKAGA 1021
                           .|||.:.....  |::.:..|||||.|:...|...:.::||:|||
Zfish  1313 RDTALTIAADKGHYKFCELLISRGAH--IDVRNKKGNTPLWLAANGGHFDVVQLLVQAGA 1370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG41099	NP_001015359.1	BTB	67..164	CDD:279045
		BTB	75..166	CDD:197585
		ANK	252..385	CDD:238125	40/166 (24%)
		ANK repeat	291..322	CDD:293786	9/46 (20%)
		ANK repeat	325..362	CDD:293786	6/36 (17%)
		Ank_2	330..431	CDD:289560	32/129 (25%)
		ANK	463..595	CDD:238125	40/206 (19%)
		ANK repeat	468..501	CDD:293786	13/41 (32%)
		Ank_2	473..572	CDD:289560	30/153 (20%)
		ANK repeat	503..539	CDD:293786	12/79 (15%)
		ANK	536..660	CDD:238125	28/180 (16%)
		ANK repeat	541..572	CDD:293786	6/32 (19%)
		ANK repeat	574..637	CDD:293786	17/94 (18%)
		Ank_2	579..670	CDD:289560	22/145 (15%)
		ANK repeat	639..670	CDD:293786	6/40 (15%)
		Ank_2	644..752	CDD:289560	30/220 (14%)
		ANK repeat	672..721	CDD:293786	14/111 (13%)
		ANK	721..843	CDD:238125	34/165 (21%)
		ANK repeat	723..752	CDD:293786	10/65 (15%)
		ANKYR	752..977	CDD:223738	66/263 (25%)
		ANK repeat	754..786	CDD:293786	6/35 (17%)
		ANK	820..944	CDD:238125	36/127 (28%)
		ANK repeat	822..855	CDD:293786	7/32 (22%)
		ANK repeat	857..888	CDD:293786	11/30 (37%)
		ANK	885..1017	CDD:238125	42/166 (25%)
		ANK repeat	890..921	CDD:293786	12/34 (35%)
		ANK repeat	923..955	CDD:293786	9/31 (29%)
		ANK repeat	996..1021	CDD:293786	10/24 (42%)
		FYVE_ANFY1	1054..1116	CDD:277267
ankhd1	XP_009293757.1	Ank_2	204..296	CDD:289560
		ANK repeat	204..230	CDD:293786
		ANK	227..353	CDD:238125	12/40 (30%)
		ANK repeat	232..264	CDD:293786
		ANK repeat	269..297	CDD:293786
		Ank_2	271..360	CDD:289560	15/48 (31%)
		ANK	294..420	CDD:238125	24/108 (22%)
		ANK repeat	299..330	CDD:293786	4/17 (24%)
		ANK repeat	332..360	CDD:293786	10/28 (36%)
		ANK	362..486	CDD:238125	27/130 (21%)
		ANK repeat	366..397	CDD:293786	3/30 (10%)
		Ank_4	369..420	CDD:290365	7/50 (14%)
		ANK repeat	401..430	CDD:293786	7/28 (25%)
		Ank_2	404..495	CDD:289560	28/98 (29%)
		ANK repeat	432..463	CDD:293786	6/36 (17%)
		ANK repeat	465..495	CDD:293786	13/30 (43%)
		ANK repeat	498..527	CDD:293786	8/28 (29%)
		Ank_4	502..550	CDD:290365	8/47 (17%)
		ANK	532..650	CDD:238125	29/119 (24%)
		ANK repeat	532..560	CDD:293786	4/27 (15%)
		Ank_2	534..624	CDD:289560	24/91 (26%)
		ANK repeat	562..593	CDD:293786	10/31 (32%)
		ANK repeat	595..624	CDD:293786	9/28 (32%)
		Ank_2	600..689	CDD:289560	17/88 (19%)
		ANK	625..>702	CDD:238125	12/76 (16%)
		ANK repeat	629..659	CDD:293786	2/29 (7%)
		Prefoldin	<816..854	CDD:298833	5/39 (13%)
		ANK	1075..1103	CDD:197603	5/28 (18%)
		ANK repeat	1077..1106	CDD:293786	5/29 (17%)
		Ank_2	1080..1173	CDD:289560	22/95 (23%)
		ANK	1104..1231	CDD:238125	38/129 (29%)
		ANK repeat	1108..1140	CDD:293786	7/31 (23%)
		ANK repeat	1142..1173	CDD:293786	7/32 (22%)
		Ank_2	1147..1240	CDD:289560	30/95 (32%)
		ANK repeat	1175..1206	CDD:293786	11/30 (37%)
		ANK repeat	1210..1240	CDD:293786	10/29 (34%)
		Ank_2	1215..1306	CDD:289560	26/91 (29%)
		ANK repeat	1243..1275	CDD:293786	9/32 (28%)
		ANK	1273..1399	CDD:238125	23/99 (23%)
		ANK repeat	1277..1306	CDD:293786	8/28 (29%)
		Ank_2	1282..1376	CDD:289560	21/90 (23%)
		ANK repeat	1314..1343	CDD:293786	4/30 (13%)
		ANK repeat	1345..1376	CDD:293786	11/25 (44%)
		KH-I	1736..1798	CDD:238053
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1115202at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010