DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG41099 and RIPK4

DIOPT Version :9

Sequence 1:NP_001015359.1 Gene:CG41099 / 3355072 FlyBaseID:FBgn0039955 Length:1124 Species:Drosophila melanogaster
Sequence 2:NP_065690.2 Gene:RIPK4 / 54101 HGNCID:496 Length:784 Species:Homo sapiens


Alignment Length:908 Identity:194/908 - (21%)
Similarity:315/908 - (34%) Gaps:308/908 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   198 HW---------DDLTTDDFQHMSGPLLFEMLKTKTKHPLHAAVRLLREDVVSLCIQKYGNSLVNT 253
            ||         ..|..||.:.|      |:|:...|..: |..|.:. .|..:|.:..|  ||..
Human    43 HWKTWLAIKCSPSLHVDDRERM------ELLEEAKKMEM-AKFRYIL-PVYGICREPVG--LVME 97

  Fly   254 FSENGILPLEMALSSK-------------------------------NAKIAKSLVD-------- 279
            :.|.|  .||..|:|:                               :.|.|..|:|        
Human    98 YMETG--SLEKLLASEPLPWDLRFRIIHETAVGMNFLHCMAPPLLHLDLKPANILLDAHYHVKIS 160

  Fly   280 -------NGMANINAVNMEG-FSLL----------KSAL--KNGDAFSANF----LLDQNCLLDL 320
                   ||:::.:.::|:| |..:          ||.|  ...|.:|...    :|.|      
Human   161 DFGLAKCNGLSHSHDLSMDGLFGTIAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQ------ 219

  Fly   321 PSKPSSD--TALHIICNYGPDNTPEIMEVVK----------KILQR------QLNINIQNIKGET 367
             .||.:|  ..|||:......:.||:..|.:          :::||      ::....|.|..||
Human   220 -KKPFADEKNILHIMVKVVKGHRPELPPVCRARPRACSHLIRLMQRCWQGDPRVRPTFQEITSET 283

  Fly   368 PLHIAIARRNVEMVK-----LLLKVPN------IDINLR-----TYDEKCALELSLSM------- 409
            .   .:..:..:.||     |.:|.|.      :...|:     |:|...:|...||.       
Human   284 E---DLCEKPDDEVKETAHDLDVKSPPEPRSEVVPARLKRASAPTFDNDYSLSELLSQLDSGVSQ 345

  Fly   410 ---GDHEFLIASILLSMGARTDRTNSKTGDSLLQVFALD---RHRGEKSAIFLADFADLDHINFR 468
               |..|      |....:.:...:|.:|..|..|.::|   ..||..|..|..:.:..|    .
Human   346 AVEGPEE------LSRSSSESKLPSSGSGKRLSGVSSVDSAFSSRGSLSLSFEREPSTSD----L 400

  Fly   469 GLTALHIAALNNMPNLVKKL---IVNGASSNL------KHIDCGLKSA---LHIAVEANAIDALE 521
            |.|.:.          .|||   ||:|.:|.|      :.:|..|.|.   ||:||||...:..:
Human   401 GTTDVQ----------KKKLVDAIVSGDTSKLMKILQPQDVDLALDSGASLLHLAVEAGQEECAK 455

  Fly   522 AFVELKNKSHDIDFNCQDINGDSPLSLCLSLKRTTLVPTLIRGGSDVNGKNKNNLSPLHQSIKNE 586
             ::.|.|.:.    |..:..|.:||.:.:..:...:|..|:.....||.|:::..:.||.:.:|.
Human   456 -WLLLNNANP----NLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNG 515

  Fly   587 DSDISLFLLEQGADITALTENLDSALDLSIKHDLSEVVDALCRRGIALSINKNGESPLWSALEKG 651
            |...:..|||:.|.:.                                .::..|.:|:..|.:.|
Human   516 DESSTRLLLEKNASVN--------------------------------EVDFEGRTPMHVACQHG 548

  Fly   652 YEDVAKILVRHGIDT-----DCWDEGPEGCRQTLLHRAIDENKESVAIFLIQSQCDLDSSRQPGP 711
            .|::.:||:|.|:|.     |.|         ..||.|..:....:...|         ::|||.
Human   549 QENIVRILLRRGVDVSLQGKDAW---------LPLHYAAWQGHLPIVKLL---------AKQPGV 595

  Fly   712 NGEGGDEAQDKASPLHLCCHWGQTKVLQTLIDHGANVNLIDAESKSPLHVAIESQYDEIISILLC 776
            :...  :..|..:||||....|..:|.:.|||..::||:....:::|||||.|:           
Human   596 SVNA--QTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAET----------- 647

  Fly   777 HPDIDLKLRDKSGNTPFATALDFRNHNAAQRILDRFPTAAEQMDIRGRNFLHLAILKDDLESVLF 841
                                    .|.:..|:|.......|.|...|...||||.....|.:|..
Human   648 ------------------------GHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKL 688

  Fly   842 LLAIQVDVNSRVHDANQSSPLHLAAASQNEMITRNLILAGARMNERDAVQKLPLHIAIERGNLPA 906
            |:..:.||.:| ...||:: ||||||..:..:...|:.|       |.:                
Human   689 LVEEKADVLAR-GPLNQTA-LHLAAAHGHSEVVEELVSA-------DVI---------------- 728

  Fly   907 VSALIQNNADYDATDADGNNALHIAVRCAQFFIVRELLTE-SRVNAEATNLK-GRNPLHELCR 967
                       |..|..|.:|||:|.:......|..||.. :.:|.::...: |..|...|.|
Human   729 -----------DLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLKFQGGHGPAATLLR 780

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG41099NP_001015359.1 BTB 67..164 CDD:279045
BTB 75..166 CDD:197585
ANK 252..385 CDD:238125 40/218 (18%)
ANK repeat 291..322 CDD:293786 9/47 (19%)
ANK repeat 325..362 CDD:293786 9/54 (17%)
Ank_2 330..431 CDD:289560 26/142 (18%)
ANK 463..595 CDD:238125 35/143 (24%)
ANK repeat 468..501 CDD:293786 10/41 (24%)
Ank_2 473..572 CDD:289560 27/110 (25%)
ANK repeat 503..539 CDD:293786 11/38 (29%)
ANK 536..660 CDD:238125 23/123 (19%)
ANK repeat 541..572 CDD:293786 7/30 (23%)
ANK repeat 574..637 CDD:293786 8/62 (13%)
Ank_2 579..670 CDD:289560 19/95 (20%)
ANK repeat 639..670 CDD:293786 11/35 (31%)
Ank_2 644..752 CDD:289560 29/112 (26%)
ANK repeat 672..721 CDD:293786 7/48 (15%)
ANK 721..843 CDD:238125 30/121 (25%)
ANK repeat 723..752 CDD:293786 11/28 (39%)
ANKYR 752..977 CDD:223738 48/218 (22%)
ANK repeat 754..786 CDD:293786 6/31 (19%)
ANK 820..944 CDD:238125 30/123 (24%)
ANK repeat 822..855 CDD:293786 11/32 (34%)
ANK repeat 857..888 CDD:293786 10/30 (33%)
ANK 885..1017 CDD:238125 16/85 (19%)
ANK repeat 890..921 CDD:293786 1/30 (3%)
ANK repeat 923..955 CDD:293786 9/32 (28%)
ANK repeat 996..1021 CDD:293786
FYVE_ANFY1 1054..1116 CDD:277267
RIPK4NP_065690.2 STKc_RIP4_like 25..290 CDD:270927 53/268 (20%)
STYKc 26..279 CDD:214568 50/254 (20%)
ANK 413..524 CDD:238125 29/115 (25%)
ANK repeat 437..468 CDD:293786 10/35 (29%)
Ank_2 442..534 CDD:289560 25/128 (20%)
ANK repeat 470..501 CDD:293786 7/30 (23%)
ANK 471..589 CDD:238125 31/158 (20%)
ANK repeat 503..534 CDD:293786 8/62 (13%)
Ank_2 508..600 CDD:289560 27/143 (19%)
ANK repeat 536..567 CDD:293786 10/30 (33%)
ANK repeat 569..600 CDD:293786 9/50 (18%)
ANK 598..723 CDD:238125 42/163 (26%)
ANK repeat 603..634 CDD:293786 12/30 (40%)
Ank_2 608..699 CDD:289560 31/125 (25%)
ANK repeat 636..667 CDD:293786 10/65 (15%)
ANK repeat 669..699 CDD:293786 10/29 (34%)
Ank_2 674..764 CDD:289560 32/125 (26%)
ANK 729..>764 CDD:238125 11/34 (32%)
ANK repeat 734..764 CDD:293786 9/29 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0192
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.