DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG41099 and TNNI3K

DIOPT Version :9

Sequence 1:NP_001015359.1 Gene:CG41099 / 3355072 FlyBaseID:FBgn0039955 Length:1124 Species:Drosophila melanogaster
Sequence 2:NP_057062.1 Gene:TNNI3K / 51086 HGNCID:19661 Length:835 Species:Homo sapiens


Alignment Length:863 Identity:166/863 - (19%)
Similarity:302/863 - (34%) Gaps:262/863 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   335 NYGPDNTPEIMEVVKKILQRQLNINIQNIKGETPLHIAIARRNVEMVKLLL----KVPNIDINLR 395
            ||....|....:..||.:.....|.|:.::.:    :.|..:.:..::.:.    ....:::|.|
Human     3 NYKSRPTQTCTDEWKKKVSESYVITIERLEDD----LQIKEKELTELRNIFGSDEAFSKVNLNYR 63

  Fly   396 TYDEKCALELSLSMGDHEFLIASILLSMGARTDRTNSKTGDSLLQVFALDRHRGEKSAIFLADFA 460
            |.:....|.|....|..:..|.:::|. |.|..|              |.|:             
Human    64 TENGLSLLHLCCICGGKKSHIRTLMLK-GLRPSR--------------LTRN------------- 100

  Fly   461 DLDHINFRGLTALHIAALNNMPNLVKKLIVNGASSNLKHIDCGLKSALHIAVEANAIDALEAFVE 525
                    |.||||:|...:...|:..|:.:||  :::.:..|..:|||||..|..::|.:..::
Human   101 --------GFTALHLAVYKDNAELITSLLHSGA--DIQQVGYGGLTALHIATIAGHLEAADVLLQ 155

  Fly   526 LKNKSHDIDFNCQDINGDSPLSLCLSLKRTTLVPTLIRGGSDVNGKNKNNLSPLHQSIKNEDSDI 590
                 |..:.|.||....:||.:........:...|::.|:|||...:....|||.:......:|
Human   156 -----HGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNI 215

  Fly   591 SLFLLEQG--ADITALTENLDSALDLSIKHDLSEVVDALCRRGIALS---INKNGESPLWSALEK 650
            :..|:|:|  ||:.|........|....:....::|..|.:..:.:.   :|..|::||..|...
Human   216 AKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYN 280

  Fly   651 GYEDVAKILVRHGIDTDCWDEGPEGC------RQTLLHRAIDENK--ESVAIFLIQSQCDLDSSR 707
            |..:|||.:::        ..|.|..      .:|..|.|....|  :.|...|.|:..:::...
Human   281 GKFEVAKEIIQ--------ISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQG 337

  Fly   708 QPGPNGEGGDEAQDKASPLHLCCHWGQTKVLQTLIDHGANVNLI---------DAESKSPLHVAI 763
            :.|..|            ||..|:.|..:::|.|:|:||::||:         :.:.::.|..|.
Human   338 RDGHTG------------LHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAY 390

  Fly   764 ESQYDEIISILLCH--PDIDLKLRDKS---GNTPFATALDFRNHNAAQRILDRFPTAAEQMDIRG 823
            |..:|.|:::|..:  |..:|...:.|   |:..:.:.                |:.        
Human   391 EKGHDAIVTLLKHYKRPQDELPCNEYSQPGGDGSYVSV----------------PSP-------- 431

  Fly   824 RNFLHLAILKDDLESVLFLLAIQVDVNSRVHDANQSSPLHLAAASQNEMI------------TRN 876
                 |..:|...:....:|.::..:.|..|       |.|:....:|:|            .||
Human   432 -----LGKIKSMTKEKADILLLRAGLPSHFH-------LQLSEIEFHEIIGSGSFGKVYKGRCRN 484

  Fly   877 LILAGARMNERDAVQKLPLHIAIERGNLPAVSALIQNNADYDATDADGNNALHIAV-----RC-- 934
            .|:|..|........|..:.:....     ||.|.|.|              |..|     .|  
Human   485 KIVAIKRYRANTYCSKSDVDMFCRE-----VSILCQLN--------------HPCVIQFVGACLN 530

  Fly   935 --AQFFIVRELLT-----------------ESRVNAEATNLKGRNPLHELCRVV----------- 969
              :||.||.:.::                 :|::.......||...||.|.:.:           
Human   531 DPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNIL 595

  Fly   970 --EDSTAGLICEL----FLESMPKYPINIPDMDGNTPLLLSFMRGQSP-----LCKILVKAGACL 1023
              ||..| ::.:.    ||:|:.:  .|:....||       :|..:|     ..:..:||    
Human   596 LYEDGHA-VVADFGESRFLQSLDE--DNMTKQPGN-------LRWMAPEVFTQCTRYTIKA---- 646

  Fly  1024 GTENKDGINIFNFKLATDQLLHNLLDQLPQESPWAESDYCQHCTNRFTITMRKHHCRHCGRVLCS 1088
                    ::|::.|.       |.:.|..|.|:|.........:     |..||.|        
Human   647 --------DVFSYALC-------LWEILTGEIPFAHLKPAAAAAD-----MAYHHIR-------- 683

  Fly  1089 KCSCNDVPILKFGINKPV 1106
                   |.:.:.|.||:
Human   684 -------PPIGYSIPKPI 694

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG41099NP_001015359.1 BTB 67..164 CDD:279045
BTB 75..166 CDD:197585
ANK 252..385 CDD:238125 8/49 (16%)
ANK repeat 291..322 CDD:293786
ANK repeat 325..362 CDD:293786 7/26 (27%)
Ank_2 330..431 CDD:289560 19/99 (19%)
ANK 463..595 CDD:238125 33/131 (25%)
ANK repeat 468..501 CDD:293786 10/32 (31%)
Ank_2 473..572 CDD:289560 26/98 (27%)
ANK repeat 503..539 CDD:293786 10/35 (29%)
ANK 536..660 CDD:238125 32/128 (25%)
ANK repeat 541..572 CDD:293786 7/30 (23%)
ANK repeat 574..637 CDD:293786 13/67 (19%)
Ank_2 579..670 CDD:289560 21/95 (22%)
ANK repeat 639..670 CDD:293786 8/30 (27%)
Ank_2 644..752 CDD:289560 28/124 (23%)
ANK repeat 672..721 CDD:293786 11/56 (20%)
ANK 721..843 CDD:238125 24/135 (18%)
ANK repeat 723..752 CDD:293786 11/37 (30%)
ANKYR 752..977 CDD:223738 47/280 (17%)
ANK repeat 754..786 CDD:293786 8/33 (24%)
ANK 820..944 CDD:238125 27/144 (19%)
ANK repeat 822..855 CDD:293786 4/32 (13%)
ANK repeat 857..888 CDD:293786 9/42 (21%)
ANK 885..1017 CDD:238125 30/179 (17%)
ANK repeat 890..921 CDD:293786 6/30 (20%)
ANK repeat 923..955 CDD:293786 8/57 (14%)
ANK repeat 996..1021 CDD:293786 6/29 (21%)
FYVE_ANFY1 1054..1116 CDD:277267 11/53 (21%)
TNNI3KNP_057062.1 ANK <56..121 CDD:238125 20/100 (20%)
ANK repeat 66..98 CDD:293786 8/46 (17%)
ANK 1 66..96 7/30 (23%)
ANK 99..220 CDD:238125 34/148 (23%)
ANK repeat 100..131 CDD:293786 10/53 (19%)
ANK 2 100..129 10/51 (20%)
ANK 3 133..162 9/33 (27%)
ANK repeat 134..164 CDD:293786 9/34 (26%)
ANK 161..290 CDD:238125 32/128 (25%)
ANK repeat 166..197 CDD:293786 7/30 (23%)
ANK 4 166..195 6/28 (21%)
ANK repeat 199..232 CDD:293786 10/32 (31%)
ANK 5 199..228 8/28 (29%)
ANK 229..360 CDD:238125 29/150 (19%)
ANK 6 234..263 3/28 (11%)
ANK repeat 234..262 CDD:293786 3/27 (11%)
ANK repeat 269..302 CDD:293786 10/40 (25%)
ANK 7 269..298 10/36 (28%)
ANK repeat 304..337 CDD:293786 7/32 (22%)
ANK 8 304..335 7/30 (23%)
ANK 334..>401 CDD:238125 18/78 (23%)
ANK repeat 339..369 CDD:293786 12/41 (29%)
ANK 9 339..368 11/40 (28%)
ANK 10 381..410 7/28 (25%)
PKc_TNNI3K 469..722 CDD:270966 53/294 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 732..751
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0192
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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