DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG41099 and Lrrk

DIOPT Version :9

Sequence 1:NP_001015359.1 Gene:CG41099 / 3355072 FlyBaseID:FBgn0039955 Length:1124 Species:Drosophila melanogaster
Sequence 2:NP_001262772.1 Gene:Lrrk / 42447 FlyBaseID:FBgn0038816 Length:2513 Species:Drosophila melanogaster


Alignment Length:520 Identity:109/520 - (20%)
Similarity:180/520 - (34%) Gaps:166/520 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   638 KNGESPLWSALEKGYEDVAKILVRHGIDTD---CWDEGPEGCRQTLLHRAIDENKESVAIFLIQS 699
            |:||  |.:|:..|.|...::|:. .:.|:   ..:..|.|. .|||..|.....||:...|:.:
  Fly   107 KHGE--LRTAVISGDERTVRVLLA-ALGTERQIIVNMAPSGA-NTLLFLACQSGYESITQRLLDA 167

  Fly   700 QCDLDSSRQPGPNGEGGDEAQDKASPLHLCCHWGQTKVLQTLIDHGAN-VNLIDAESKSPLHVAI 763
            ..|            |...|..|.|||:...|.|...:.:.::||... :.....|...|||.|.
  Fly   168 GAD------------GRSHAVTKYSPLYAAVHSGHLGIARLMLDHFPELIQQPTVERWLPLHAAC 220

  Fly   764 ESQYDEIISILL--CHPD-IDLKLRDKSGNTPFATALDFRNHNAAQRILDRFPTAAEQMDIRGRN 825
            .:.:.:::.:|:  .:|| :....||:.|...:                 |.|..|...|:.|:.
  Fly   221 INGHIKLLELLISYSYPDYLYQTYRDEEGQWEW-----------------RLPFDANAHDVTGQT 268

  Fly   826 FLHLAILKDDLESVLFLLAIQVDVNSRVHDANQS--------------------SPLHLAA---- 866
            .|::|.:..:.:.|..||..|:.....:.|:..|                    |.||::.    
  Fly   269 SLYIASILGNKQLVGVLLKWQLHCRRTLGDSASSVSTPITPTRKRISFGIQAIMSKLHISGESEG 333

  Fly   867 ----ASQNEM------ITRNLILAGARMNERDAVQKLPLHIAIERGNLPAVSALIQNNAD----- 916
                |||...      |..||:...||        :..|..|:..|:|..|.:|:|:.|:     
  Fly   334 PDDLASQESTECQRCPINVNLLCGAAR--------ETALLAAVRGGHLDVVQSLLQHGANPNIVA 390

  Fly   917 ----------------------------------------YDATDADGNNALHIAVRCAQFFIVR 941
                                                    :.|.| |...|:.:|:.|....|:.
  Fly   391 KPVEDHNDPKCCEEIYGLSNVPIAEACKQRSLAMLDLLLKHGARD-DNGTAIGMAITCGDEAILS 454

  Fly   942 ELLTESRVNAEA---TNLKGRNPLHELCRVVEDSTAGLICELFLESMPKYPINIPDMDGNTPLLL 1003
            .||.. ||:.::   .|.||      |...||       ..:||.|...  |:...|..|.|.::
  Fly   455 RLLAR-RVHPDSDYKINKKG------LPTPVE-------VNVFLPSTSN--ISYSAMFPNNPTII 503

  Fly  1004 SFMRGQSPLCKILVKAGACLGTENKDGINIFNFKLATDQLL--------------HNLLDQLPQE 1054
            .:....|.:...:|:....:     .|:.:.|.||.:...|              ||:|..:|||
  Fly   504 DWHSMGSSVQLSVVRVPWMV-----SGVLLLNPKLQSHPRLNEVALTAITRIDFSHNVLTSIPQE 563

  Fly  1055  1054
              Fly   564  563

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG41099NP_001015359.1 BTB 67..164 CDD:279045
BTB 75..166 CDD:197585
ANK 252..385 CDD:238125
ANK repeat 291..322 CDD:293786
ANK repeat 325..362 CDD:293786
Ank_2 330..431 CDD:289560
ANK 463..595 CDD:238125
ANK repeat 468..501 CDD:293786
Ank_2 473..572 CDD:289560
ANK repeat 503..539 CDD:293786
ANK 536..660 CDD:238125 7/21 (33%)
ANK repeat 541..572 CDD:293786
ANK repeat 574..637 CDD:293786
Ank_2 579..670 CDD:289560 9/34 (26%)
ANK repeat 639..670 CDD:293786 8/33 (24%)
Ank_2 644..752 CDD:289560 26/111 (23%)
ANK repeat 672..721 CDD:293786 12/48 (25%)
ANK 721..843 CDD:238125 27/125 (22%)
ANK repeat 723..752 CDD:293786 7/29 (24%)
ANKYR 752..977 CDD:223738 60/309 (19%)
ANK repeat 754..786 CDD:293786 8/34 (24%)
ANK 820..944 CDD:238125 36/202 (18%)
ANK repeat 822..855 CDD:293786 7/32 (22%)
ANK repeat 857..888 CDD:293786 12/64 (19%)
ANK 885..1017 CDD:238125 33/179 (18%)
ANK repeat 890..921 CDD:293786 9/75 (12%)
ANK repeat 923..955 CDD:293786 9/34 (26%)
ANK repeat 996..1021 CDD:293786 4/24 (17%)
FYVE_ANFY1 1054..1116 CDD:277267 1/1 (100%)
LrrkNP_001262772.1 Ank_2 111..200 CDD:289560 24/102 (24%)
ANK 146..286 CDD:238125 37/168 (22%)
ANK repeat 146..177 CDD:293786 10/42 (24%)
Ank_4 179..232 CDD:290365 12/52 (23%)
ANK repeat 179..209 CDD:293786 7/29 (24%)
Ank_2 216..389 CDD:289560 41/197 (21%)
ANK 361..477 CDD:238125 23/123 (19%)
ANK repeat 361..390 CDD:293786 8/28 (29%)
Ank_2 364..464 CDD:289560 19/101 (19%)
ANK repeat 406..435 CDD:293786 1/28 (4%)
ANK repeat 437..464 CDD:293786 8/27 (30%)
LRR_8 <544..580 CDD:290566 6/20 (30%)
leucine-rich repeat 547..569 CDD:275380 6/17 (35%)
LRR_8 569..629 CDD:290566
leucine-rich repeat 570..595 CDD:275380
leucine-rich repeat 596..618 CDD:275380
leucine-rich repeat 619..641 CDD:275380
leucine-rich repeat 642..676 CDD:275380
leucine-rich repeat 677..730 CDD:275380
LRR_8 729..788 CDD:290566
leucine-rich repeat 731..754 CDD:275380
LRR_8 855..933 CDD:290566
leucine-rich repeat 855..901 CDD:275380
leucine-rich repeat 902..924 CDD:275380
leucine-rich repeat 925..949 CDD:275380
P-loop_NTPase 993..1211 CDD:304359
COR 1230..1471 CDD:292713
STYKc 1796..2092 CDD:214568
STKc_LRRK 1801..2095 CDD:270902
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0192
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.900

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