DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG41099 and dstyk

DIOPT Version :9

Sequence 1:	NP_001015359.1	Gene:	CG41099 / 3355072	FlyBaseID:	FBgn0039955	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	XP_005168327.1	Gene:	dstyk / 402922	ZFINID:	ZDB-GENE-040826-2	Length:	885	Species:	Danio rerio

Alignment Length:	808	Identity:	153/808 - (18%)
Similarity:	258/808 - (31%)	Gaps:	303/808 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 LLEYCSSIISTHWDDLTTDD--FQHMSGPL--LFEMLKTKTKHPLHAAVRLLREDVVSLC--IQK 245
            |..:|.     .||.:...|  .|....|.  |.| |:....|.|...|:::    |..|  :|.
Zfish   146 LAAHCG-----RWDTVPRQDLEIQECEDPAQRLAE-LEITLHHTLLQEVKIM----VLPCRNVQP 200

  Fly   246 YGNSLVNTFSENGILPLEMALSSKNAKIAKSLVDNGMANINAVNMEGFSLLKSAL-------KNG 303
            ...:|.:  .:.||||:.:...|:.             :::|..:|....|:.:|       :..
Zfish   201 LEEALED--CKRGILPIVLYAVSRE-------------SLSAQQLEDLQTLRESLPFPVCFIRVS 250

  Fly   304 DAFSANFLLDQ------------NCLLDLPSKPSSDTALHIICNYGPDNTPEIMEVV----KKIL 352
            |......|..|            ||....|:..|:.....::|    |:...:..|:    :::|
Zfish   251 DGGGGGALFTQLASLQLISASAGNCACGAPAAQSAGRMQGVLC----DSLERLQRVLVPFTRQVL 311

  Fly   353 QRQLNINIQNIKGETPLHIAIARRNVEMVKLLLKVPNIDINLRTYDEKCALELSLSMGDHEFLIA 417
            |.|                     .||...|          |.|...:| |:|        |:|.
Zfish   312 QNQ---------------------QVEAATL----------LNTIHCRC-LDL--------FIIQ 336

  Fly   418 SI-----LLSMGARTDRTNSKTGDSLLQVFALDRHRGEKSAIFLAD---------FADLDHINFR 468
            :.     |.....|.:.|..|.|:....:.|:...:.|:....:.:         ..|..:::|.
Zfish   337 AFDMQRDLQITPRRLEYTREKEGELFCSLMAIANRKQEEMKEMIVETLSSMKEQLLEDAQNLDFT 401

  Fly   469 GLTALHIAALNNMP----------NLVKKLIVNGASSNLKHIDCGLKSALHIAVE---ANAIDAL 520
            .:    |.:.|..|          :.::.||||               .|:.||.   .|::|.|
Zfish   402 DI----IMSSNGEPVSSKDIKVCISQIQDLIVN---------------RLNQAVANKLTNSVDYL 447

  Fly   521 -EAFVELKNKSHDIDFNCQDINGDSPLSLCL-SLKRTTLVPTLIRGGSDVNGKNKNNLSPL---- 579
             |:||                   ..|..|| ||:::|  |.     |..:....|:|..:
Zfish   448 RESFV-------------------GTLERCLGSLEKST--PE-----SCAHNVTSNHLKQILNAA 486

  Fly   580 -HQSIK-NEDSDISLFLLEQGADIT-ALTENLDSALDLSIKHDLS-EVVDALCRRGIALSINKNG 640
             |..:. :..|.::....||...|. .:|.....|:....|..:: :.:::|....:|.||....
Zfish   487 YHVEVTFHSGSSVTRLFWEQIKQIIHRITWVNPPAITAEWKRKVAQDAIESLSAAKLAKSICSQF 551

  Fly   641 ESPLWSA----------LEKGY---------------EDVAKILVRHGIDTDCWDEGPEGCRQTL 680
            .:.|.|:          ||:|:               :|.|..|.|..:::       ...|..|
Zfish   552 RTRLNSSHEAFAASLRQLEEGHTGRLERTEDLWLRVRKDHAPRLARLSLES-------RSLRDIL 609

  Fly   681 LH------RAIDENKESVAIFLIQS-----QCDLDSSRQPGPNGEGGDEAQDKASPLHLCCHWGQ 734
            ||      |.:...:..| ::|..|     .|.|.|...|          .||        ||..
Zfish   610 LHGKPKLGRELGRGQYGV-VYLCDSWAGRHPCALKSVVPP----------DDK--------HWND 655

  Fly   735 TKV----LQTLIDHGANVNLIDAESKSPLHVAIESQYD--EIISILL----CHPDI------DLK 783
            ..:    .::|..|...|||..:        .|:..|.  ..|::||    .|.|:      .|.
Zfish   656 LALEFHYTRSLPKHERLVNLHGS--------VIDHSYSGGSSIAVLLIMERLHRDLYTGLKAGLS 712

  Fly   784 LRDKSGNTPFATALDFRNHNAAQRILDRFPTAAEQMDIRGRNFLH-LAILKDDLESVLFLLAIQ- 846
            |:::     ...|||.                     :.|..||| ..:|..|::....||..|
Zfish   713 LKER-----LLIALDV---------------------VEGIRFLHSQGLLHRDIKLKNVLLDKQN 751

  Fly   847 ----VDVNSRVHDANQS-----SPLHLA 865
                .|:.....:|..|     :|:|:|
Zfish   752 RAKITDLGFCKPEAMMSGSIVGTPIHMA 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG41099	NP_001015359.1	BTB	67..164	CDD:279045
		BTB	75..166	CDD:197585
		ANK	252..385	CDD:238125	25/155 (16%)
		ANK repeat	291..322	CDD:293786	8/49 (16%)
		ANK repeat	325..362	CDD:293786	7/40 (18%)
		Ank_2	330..431	CDD:289560	18/109 (17%)
		ANK	463..595	CDD:238125	29/152 (19%)
		ANK repeat	468..501	CDD:293786	7/42 (17%)
		Ank_2	473..572	CDD:289560	24/113 (21%)
		ANK repeat	503..539	CDD:293786	9/39 (23%)
		ANK	536..660	CDD:238125	29/157 (18%)
		ANK repeat	541..572	CDD:293786	8/31 (26%)
		ANK repeat	574..637	CDD:293786	13/70 (19%)
		Ank_2	579..670	CDD:289560	21/123 (17%)
		ANK repeat	639..670	CDD:293786	9/55 (16%)
		Ank_2	644..752	CDD:289560	30/147 (20%)
		ANK repeat	672..721	CDD:293786	12/59 (20%)
		ANK	721..843	CDD:238125	27/138 (20%)
		ANK repeat	723..752	CDD:293786	7/32 (22%)
		ANKYR	752..977	CDD:223738	27/137 (20%)
		ANK repeat	754..786	CDD:293786	9/43 (21%)
		ANK	820..944	CDD:238125	15/57 (26%)
		ANK repeat	822..855	CDD:293786	10/38 (26%)
		ANK repeat	857..888	CDD:293786	4/14 (29%)
		ANK	885..1017	CDD:238125
		ANK repeat	890..921	CDD:293786
		ANK repeat	923..955	CDD:293786
		ANK repeat	996..1021	CDD:293786
		FYVE_ANFY1	1054..1116	CDD:277267
dstyk	XP_005168327.1	PKc_Dusty	613..874	CDD:270877	44/220 (20%)
dstyk	XP_005168327.1	S_TKc	615..859	CDD:214567	44/218 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900