DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG41099 and Tak1

DIOPT Version :9

Sequence 1:	NP_001015359.1	Gene:	CG41099 / 3355072	FlyBaseID:	FBgn0039955	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_524080.1	Gene:	Tak1 / 39659	FlyBaseID:	FBgn0026323	Length:	678	Species:	Drosophila melanogaster

Alignment Length:	746	Identity:	135/746 - (18%)
Similarity:	229/746 - (30%)	Gaps:	246/746 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 ALDLLKAAHRFGLPSLLGICERALVTSVGVRSCIRFYCVAEEVGASTLLEYCSSIISTHWDDLTT 204
            :||.|:||:       :...|..|...||..|   :..|.:.|....|:.......|....|:..
  Fly     5 SLDALQAAY-------VDFSEITLREKVGHGS---YGVVCKAVWRDKLVAVKEFFASAEQKDIEK 59

  Fly   205 DDFQHMSGPLLFEMLKTKTKHPLHAAVRLLREDVVSL-CIQKYGNS--LVNTFSENGIL------ 260
            :..|           .::.|||          ::::| .|..|..:  |:..|:|.|.|
  Fly    60 EVKQ-----------LSRVKHP----------NIIALHGISSYQQATYLIMEFAEGGSLHNFLHG 103

  Fly   261 PLEMALSSKNAKIAKSLVDNGMANINAVNMEGFSLLKSALKNGDAFSANFLLDQNCLLDLPSKPS 325
            .::.|.|..:|.........|:|.::|       :....|.:.|....|.||
  Fly   104 KVKPAYSLAHAMSWARQCAEGLAYLHA-------MTPKPLIHRDVKPLNLLL------------- 148

  Fly   326 SDTALHI-ICNYG---------PDN-------TPEIME---------------VVKKILQRQ--- 355
            ::...:: ||::|         .:|       .||:.|               |:.::|.|:
  Fly   149 TNKGRNLKICDFGTVADKSTMMTNNRGSAAWMAPEVFEGSKYTEKCDIFSWAIVLWEVLSRKQPF 213

  Fly   356 ------LNINIQNIKGETPLHIAIARRNVE--MVKLLLKVPN--------IDINLRTYDEKCALE 404
                  ..|..:..|||.|..:....:.:|  |......||.        :.:......:....:
  Fly   214 KGIDNAYTIQWKIYKGERPPLLTTCPKRIEDLMTACWKTVPEDRPSMQYIVGVMHEIVKDYTGAD 278

  Fly   405 LSLSMGDHEFLIASILLSMGARTDRTNSKTGDSLLQVFALDRHRGEKSAIFLADFADLDHINFRG 469
            .:|   ::.|:...|:         |....|....|..:|....||.|.            :...
  Fly   279 KAL---EYTFVNQQIV---------TKESDGTVAAQPDSLSSQEGELSP------------SSTQ 319

  Fly   470 LTALHIAALNNMPNLVKKLIVNGASSNLKHIDCGLKSALHIAVEANAI--------DALEAFVEL 526
            ||....|..|.....:.|...:..:.|.......:.......::.|.:        ||:..  |.
  Fly   320 LTPTTAANANVNAIAISKTTTSSMTENTSSTSSDITPTNSGQLDNNPLFYMVTNRWDAIPE--EE 382

  Fly   527 KNKSHDIDFN----------CQDINGDSPLSLCLSLKRTTLVPTLIRGGSDVNGKNKNNLSPLHQ 581
            .|:|.:..||          .:.|.....|..|..:::.||         ||.. |..:|||
  Fly   383 SNESRNDSFNLTSSAEATQRLETIRNGMILMACKPMEQLTL---------DVEA-NGFDLSP--- 434

  Fly   582 SIKNEDSDISLFLLEQGADITALTENLDSALDLSIKHDLSEVVDALCRRGIALSINKNGESPLWS 646
               :|.|..|......|.:...:|:    ...:.:..|||.....:......|..:.||    |.
  Fly   435 ---SESSSSSTNAKSDGRERLTVTD----TKPVMMTTDLSNNNGGIHAHSNGLLSHANG----WQ 488

  Fly   647 ALE---KGYEDVAKILVRHGIDTDCWDEGPEGCRQTLLHRAIDENKESVAIFLIQSQCDLDSSRQ 708
            |.:   :..|...:|:....:|.|..::..:|..|:|..                   .||...|
  Fly   489 ARDEELQEQEHEQEIVNSLDVDVDPDEDENDGTEQSLAE-------------------ILDPELQ 534

  Fly   709 PGPNGEGGDEAQDKASPLHLCCHWGQTKVLQTLI--DH--------GANVNLIDAES-KSPLHVA 762
            |.|......|:|                    ||  ||        ..:.||..|:. |..|.|.
  Fly   535 PEPPIPNDAESQ--------------------LIYRDHRHMAKEYLSVDTNLYYAQDFKDKLIVQ 579

  Fly   763 IE----SQYDEIISILLCHPDIDLKLRDKSG 789
            ::    .|..|::.          |::||.|
  Fly   580 MDRTEREQKQELLR----------KMKDKEG 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG41099	NP_001015359.1	BTB	67..164	CDD:279045	6/23 (26%)
		BTB	75..166	CDD:197585	7/25 (28%)
		ANK	252..385	CDD:238125	32/181 (18%)
		ANK repeat	291..322	CDD:293786	5/30 (17%)
		ANK repeat	325..362	CDD:293786	11/77 (14%)
		Ank_2	330..431	CDD:289560	22/151 (15%)
		ANK	463..595	CDD:238125	28/149 (19%)
		ANK repeat	468..501	CDD:293786	6/32 (19%)
		Ank_2	473..572	CDD:289560	19/116 (16%)
		ANK repeat	503..539	CDD:293786	8/53 (15%)
		ANK	536..660	CDD:238125	27/136 (20%)
		ANK repeat	541..572	CDD:293786	6/30 (20%)
		ANK repeat	574..637	CDD:293786	12/62 (19%)
		Ank_2	579..670	CDD:289560	17/93 (18%)
		ANK repeat	639..670	CDD:293786	8/33 (24%)
		Ank_2	644..752	CDD:289560	22/120 (18%)
		ANK repeat	672..721	CDD:293786	9/48 (19%)
		ANK	721..843	CDD:238125	16/84 (19%)
		ANK repeat	723..752	CDD:293786	6/38 (16%)
		ANKYR	752..977	CDD:223738	10/43 (23%)
		ANK repeat	754..786	CDD:293786	6/36 (17%)
		ANK	820..944	CDD:238125
		ANK repeat	822..855	CDD:293786
		ANK repeat	857..888	CDD:293786
		ANK	885..1017	CDD:238125
		ANK repeat	890..921	CDD:293786
		ANK repeat	923..955	CDD:293786
		ANK repeat	996..1021	CDD:293786
		FYVE_ANFY1	1054..1116	CDD:277267
Tak1	NP_524080.1	TyrKc	19..264	CDD:197581	51/288 (18%)
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	50/293 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900