DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG41099 and Ankrd55

DIOPT Version :9

Sequence 1:	NP_001015359.1	Gene:	CG41099 / 3355072	FlyBaseID:	FBgn0039955	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	XP_006232002.1	Gene:	Ankrd55 / 361898	RGDID:	1307735	Length:	614	Species:	Rattus norvegicus

Alignment Length:	521	Identity:	111/521 - (21%)
Similarity:	193/521 - (37%)	Gaps:	142/521 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 LEYCSSIISTHWDDLTTDDFQHMSGPLLFEMLKTKTKHPLHAAVRLLREDVVSLCIQKYGNSLVN 252
            :::.||.:   :|....|..:.:...::::.......:.|.|   ::|||          .|::.
  Rat     7 MDFSSSSV---FDQHKGDSSEEVDLTMVYQAASNGDVNSLTA---VIRED----------PSILE 55

  Fly   253 TFSENGILPLEMALSSKNAKIAKSLVDNGMANINAVNMEGFSLL------------KSALKNGDA 305
            .....|..||..|:|.:.....|.|:..| ||||..:..|.:.|            .|.|:||
  Rat    56 CCDSEGCTPLMHAVSGRQVDTVKLLLKMG-ANINTQDAYGRTSLCLATYLGWLEGCVSLLRNG-- 117

  Fly   306 FSANFLLDQNCLLDLPSKPSSDTALHIICNYGPDNTPEIMEVVKKILQRQLN-INIQNIKGETPL 369
             :.:.:.|:|..|.|.:..:.               |::..::..:.|..|: ||.|:.:|.|||
  Rat   118 -AKHNIPDKNGRLPLHAATAE---------------PDVRLLIVLLQQSSLSEINHQDTEGMTPL 166

  Fly   370 HIAIARRNVEMVKLLLKVPNIDINLRTYDEKCALELSLSMGDHEFLIASILLSMGARTDRTNSKT 434
            |.|......:..::||| ...|..|...|.|.||..::..|:.  ::.||:||
  Rat   167 HWAAFHNRPQHTQMLLK-KGADPTLVDKDFKTALHWAVQSGNR--ILCSIILS------------ 216

  Fly   435 GDSLLQVFALDRHRGEKSAIFLADFADLDHINFRGLTALHIAALNNMPNLVKKLIVNGASSNLKH 499
                        ||...|.|...|.:        |.|.:||||.:...:::..| ......||:.
  Rat   217 ------------HRQGPSIINYDDES--------GKTCVHIAAASGFGDIIHDL-AKVPECNLQA 260

  Fly   500 IDCGLKSALHIAVEANAIDALEAFVELKNKSHDIDFNCQDINGDSPLSLCLSLKRTTLVPTLIRG 564
            :|...::.||.|..|...:.:::.::|     .:|.|.:|||..:||:..|....|..|..|.|.
  Rat   261 LDVDDRTPLHWAAAAGKAECVQSLLDL-----GMDSNLRDINESTPLAYALYCGHTACVRLLSRE 320

  Fly   565 G-------------------------SDVNGKNKNNLSPLHQS------IKNEDSDISLFLLEQG 598
            |                         :.:..|||......||.      .|.||:
  Rat   321 GRAEPARPLPSQNSQPQKKEGRFSVLNQIFCKNKKEEQKAHQKEQSRARPKEEDT---------- 375

  Fly   599 ADITALTENLDSALDLSIKHDLSEVVDALCRRGIALSINKNGESPLWSALEKGYEDVAKILVRHG 663
            :::..:....||.:|.:.:....:.||.:..:      .:..|:..:...||      |.|.|.|
  Rat   376 SEVNDIIATFDSVVDTNCQDQPGDQVDMVVFK------KRTSENSKYLLPEK------KSLARKG 428

  Fly   664 I 664
            :
  Rat   429 L 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG41099	NP_001015359.1	BTB	67..164	CDD:279045
		BTB	75..166	CDD:197585
		ANK	252..385	CDD:238125	34/145 (23%)
		ANK repeat	291..322	CDD:293786	10/42 (24%)
		ANK repeat	325..362	CDD:293786	5/37 (14%)
		Ank_2	330..431	CDD:289560	26/101 (26%)
		ANK	463..595	CDD:238125	36/162 (22%)
		ANK repeat	468..501	CDD:293786	9/32 (28%)
		Ank_2	473..572	CDD:289560	26/123 (21%)
		ANK repeat	503..539	CDD:293786	7/35 (20%)
		ANK	536..660	CDD:238125	29/154 (19%)
		ANK repeat	541..572	CDD:293786	9/55 (16%)
		ANK repeat	574..637	CDD:293786	10/68 (15%)
		Ank_2	579..670	CDD:289560	17/92 (18%)
		ANK repeat	639..670	CDD:293786	7/26 (27%)
		Ank_2	644..752	CDD:289560	6/21 (29%)
		ANK repeat	672..721	CDD:293786
		ANK	721..843	CDD:238125
		ANK repeat	723..752	CDD:293786
		ANKYR	752..977	CDD:223738
		ANK repeat	754..786	CDD:293786
		ANK	820..944	CDD:238125
		ANK repeat	822..855	CDD:293786
		ANK repeat	857..888	CDD:293786
		ANK	885..1017	CDD:238125
		ANK repeat	890..921	CDD:293786
		ANK repeat	923..955	CDD:293786
		ANK repeat	996..1021	CDD:293786
		FYVE_ANFY1	1054..1116	CDD:277267
Ankrd55	XP_006232002.1	Ank_2	32..124	CDD:289560	24/108 (22%)
		ANK	57..215	CDD:238125	46/179 (26%)
		ANK repeat	60..91	CDD:293786	12/31 (39%)
		ANK repeat	93..124	CDD:293786	6/33 (18%)
		Ank_2	98..192	CDD:289560	26/112 (23%)
		ANK	121..250	CDD:238125	41/178 (23%)
		ANK repeat	126..159	CDD:293786	8/47 (17%)
		ANK repeat	161..192	CDD:293786	11/31 (35%)
		Ank_2	166..295	CDD:289560	39/169 (23%)
		ANK repeat	194..262	CDD:293786	23/102 (23%)
		Ank_4	197..250	CDD:290365	18/86 (21%)
		ANK	225..>321	CDD:238125	28/109 (26%)
		ANK repeat	230..255	CDD:293786	7/33 (21%)
		ANK repeat	264..295	CDD:293786	7/35 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1115202at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010