DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG41099 and ANKRD42

DIOPT Version :9

Sequence 1:	NP_001015359.1	Gene:	CG41099 / 3355072	FlyBaseID:	FBgn0039955	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_001287904.1	Gene:	ANKRD42 / 338699	HGNCID:	26752	Length:	527	Species:	Homo sapiens

Alignment Length:	404	Identity:	86/404 - (21%)
Similarity:	140/404 - (34%)	Gaps:	127/404 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   460 ADLDHINFRGLTALHIAALNNMPNLVKKLIVNGASSNLKHIDCGLKSALHIAVEANAIDALEAFV 524
            ||:.|:..||.||.||||:......|:.||:|||
Human    84 ADITHVTTRGWTASHIAAIRGQDACVQALIMNGA------------------------------- 117

  Fly   525 ELKNKSHDIDFNCQDINGDSPLSLCLSLKRTTLVPTLIRGGSDVNGKNKNNLSPLHQSIKNEDSD 589
                     :...||..|.:||.|..:...:..:..::|.|.|.:..:|....|:|.:..:....
Human   118 ---------NLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLG 173

  Fly   590 ISLFLLEQGADITALTENLDSALDLSIKHDLSEVVDALCRRGIALSINKNGESPLWSALEKGYED 654
            ....|::.|..|    |::|                            .||..|:..|..:|:..
Human   174 CLQLLVKWGCSI----EDVD----------------------------YNGNLPVHLAAMEGHLH 206

  Fly   655 VAKILVRHGIDTDCWDEGPEGCRQTLLHRAIDENKESVAIFLIQSQCDLDSSRQ----------P 709
            ..|.||..          .....|.|  :|.::|.|:|          ||.:::          .
Human   207 CFKFLVSR----------MSSATQVL--KAFNDNGENV----------LDLAQRFFKQNILQFIQ 249

  Fly   710 GPNGEGGD--EAQDKASPLHLCCHWGQTKVLQTLIDHGA-NVNLIDAESKSPLHVAIESQYDEII 771
            |...||.|  :.:..|.|.|:....|...:|:.|::.|. |:|.......:|:|.|....:.|.:
Human   250 GAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECL 314

  Fly   772 SILLCHPDIDLKLRDKSGNTPFATALDFRNHNAAQRILDRFPTAAEQMDIRGRN---------FL 827
            ..|: ....|..:.:|:|..|...|..|. |.||.::|:..    ::.||...|         |:
Human   315 QWLI-KMGADSNITNKAGERPSDVAKRFA-HLAAVKLLEEL----QKYDIDDENEIDENDVKYFI 373

  Fly   828 HLAI-----LKDDL 836
            ...:     .||||
Human   374 RHGVEGSTDAKDDL 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG41099	NP_001015359.1	BTB	67..164	CDD:279045
		BTB	75..166	CDD:197585
		ANK	252..385	CDD:238125
		ANK repeat	291..322	CDD:293786
		ANK repeat	325..362	CDD:293786
		Ank_2	330..431	CDD:289560
		ANK	463..595	CDD:238125	27/131 (21%)
		ANK repeat	468..501	CDD:293786	14/32 (44%)
		Ank_2	473..572	CDD:289560	19/98 (19%)
		ANK repeat	503..539	CDD:293786	0/35 (0%)
		ANK	536..660	CDD:238125	23/123 (19%)
		ANK repeat	541..572	CDD:293786	7/30 (23%)
		ANK repeat	574..637	CDD:293786	7/62 (11%)
		Ank_2	579..670	CDD:289560	14/90 (16%)
		ANK repeat	639..670	CDD:293786	8/30 (27%)
		Ank_2	644..752	CDD:289560	26/120 (22%)
		ANK repeat	672..721	CDD:293786	12/60 (20%)
		ANK	721..843	CDD:238125	32/131 (24%)
		ANK repeat	723..752	CDD:293786	9/29 (31%)
		ANKYR	752..977	CDD:223738	23/99 (23%)
		ANK repeat	754..786	CDD:293786	6/31 (19%)
		ANK	820..944	CDD:238125	8/31 (26%)
		ANK repeat	822..855	CDD:293786	6/29 (21%)
		ANK repeat	857..888	CDD:293786
		ANK	885..1017	CDD:238125
		ANK repeat	890..921	CDD:293786
		ANK repeat	923..955	CDD:293786
		ANK repeat	996..1021	CDD:293786
		FYVE_ANFY1	1054..1116	CDD:277267
ANKRD42	NP_001287904.1	ANK	<17..80	CDD:238125
		Ank_4	26..80	CDD:290365
		ANK repeat	30..56	CDD:293786
		ANK	59..179	CDD:238125	29/134 (22%)
		ANK repeat	59..90	CDD:293786	3/5 (60%)
		Ank_2	64..156	CDD:289560	26/111 (23%)
		ANK repeat	92..123	CDD:293786	14/70 (20%)
		ANKYR	94..375	CDD:223738	77/380 (20%)
		ANK	121..248	CDD:238125	33/180 (18%)
		ANK repeat	125..156	CDD:293786	7/30 (23%)
		ANK repeat	158..189	CDD:293786	6/34 (18%)
		ANK	188..350	CDD:238125	44/213 (21%)
		ANK repeat	297..328	CDD:293786	6/31 (19%)
		Prefoldin	<394..482	CDD:298833
		HalX	<430..472	CDD:285826
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1115202at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010