DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG41099 and Lrrk1

DIOPT Version :9

Sequence 1:NP_001015359.1 Gene:CG41099 / 3355072 FlyBaseID:FBgn0039955 Length:1124 Species:Drosophila melanogaster
Sequence 2:NP_001178553.1 Gene:Lrrk1 / 308703 RGDID:1308000 Length:2013 Species:Rattus norvegicus


Alignment Length:657 Identity:133/657 - (20%)
Similarity:209/657 - (31%) Gaps:230/657 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   541 NGDSPLSLCLSLKRTTLVPTLIRGGSDVNGKNKNNLSPLHQSIKNEDSDISLFLLEQGADITALT 605
            ||...:...|||.         .|.|.|...   |:..:|.:.|..:...:..||.:..:.:...
  Rat    32 NGAEDMGSKLSLP---------GGNSPVQSP---NMEEIHTAYKQRNLSRARDLLREVCEESESP 84

  Fly   606 ENLDSALDLSIKH-DLSEVVDALCRRGIALSINKNGESPL------------------------- 644
            :.....|.:|..| ||..|...|..:.:.|.:....::|.                         
  Rat    85 QEKGQLLSISAAHGDLETVRFLLTEKRVELPMEPTDDNPAVVAAHFGHAEVVHELLESLSGPCAS 149

  Fly   645 -----WS---ALEKGYEDVAKILV-RHGIDTDCW----DEGPEGCRQTLLHRAIDENKESVAIFL 696
                 |.   |.::|:.:|.|:|| .||.|.:.:    :|.|...|.. |:.||....|.:||||
  Rat   150 QRLLNWMLALACQRGHLEVVKLLVLTHGADPENYAVRKNEFPVIVRLP-LYAAIKAGNEDIAIFL 213

  Fly   697 IQ------SQCDLDSSRQPGPNGEGGDEAQDKASPL--------HLCCHWGQTKV----LQTLID 743
            ::      |...|||   |.|:.....:...:||.|        .||..|...|:    |..|:|
  Rat   214 LRHGAYFCSYILLDS---PDPSKHLLRKYFIEASALPSSCPGKTALCVKWSHLKLPWVDLDWLLD 275

  Fly   744 HGANVNLIDAESK---------------------SPLHV----AIESQYDEIISILLCHPDID-- 781
            ....:..:|..:.                     |..|:    .::|. ||||...|...||.  
  Rat   276 ISCQITELDLSANCLSSLPSIIPWGLINLKKLNLSNNHLGELPCVQSS-DEIICSRLVEIDISSN 339

  Fly   782 ------------LKLRDKSGNTPFATALDFRNHNAAQRILDRFPTAAEQMDIRGRNFLHLAILKD 834
                        .||...:.:..:...| |...||...|..|   ..|::|:.......|.:  .
  Rat   340 KLSHLPPGFLHLSKLERLTASKNYLERL-FEEENATNWIGLR---KLEELDLADNRLTELPV--Q 398

  Fly   835 DLESVLFLLAIQVDVNS-RVHDANQSSPLHLAAASQNEMITRNLILAGARMNERDAVQKLPLHIA 898
            .:.|...|..:.|..|| :......|.||....||:|                  |::.||..:|
  Rat   399 FMHSFKSLTNLNVSRNSLKSFPDPWSCPLKCCKASKN------------------ALESLPDKMA 445

  Fly   899 I-----------ERGNLPAVS-ALIQNNADYDATDA------DGNNAL----HIAVRCAQFFIV- 940
            :           ...:|.||. .:.|       .||      .||..|    |....|.|...: 
  Rat   446 VFWKNHLRDVDFSENSLKAVPLGVFQ-------LDALMFLRLQGNLLLSLPHHEKWTCRQLKTLD 503

  Fly   941 ---------RELLTESRVNAEATNLKGRNPLHELCRVVE-------------------DSTAGLI 977
                     .:.|...|::...|..:.|:.. |...|:|                   |:....:
  Rat   504 LSRNQLGKNEDGLKTKRISLFTTRGRQRSGT-ETASVLEFPAFLSESLEVLCLNDNHLDAVPPSV 567

  Fly   978 C------ELFLESMP--------------KYPINIPDMD-GNTP---------LLLSFMRGQ--- 1009
            |      ||:|.:.|              .:.::|.|:: ||.|         ..|||:|.|   
  Rat   568 CLLKNLSELYLGNNPGLRELPPELGQLGNLWQLDIEDLNIGNVPAEVRKEGPKATLSFLRAQLRK 632

  Fly  1010 SPLCKIL 1016
            :..||::
  Rat   633 AEKCKLM 639

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG41099NP_001015359.1 BTB 67..164 CDD:279045
BTB 75..166 CDD:197585
ANK 252..385 CDD:238125
ANK repeat 291..322 CDD:293786
ANK repeat 325..362 CDD:293786
Ank_2 330..431 CDD:289560
ANK 463..595 CDD:238125 11/53 (21%)
ANK repeat 468..501 CDD:293786
Ank_2 473..572 CDD:289560 8/30 (27%)
ANK repeat 503..539 CDD:293786
ANK 536..660 CDD:238125 27/152 (18%)
ANK repeat 541..572 CDD:293786 8/30 (27%)
ANK repeat 574..637 CDD:293786 13/63 (21%)
Ank_2 579..670 CDD:289560 23/129 (18%)
ANK repeat 639..670 CDD:293786 11/68 (16%)
Ank_2 644..752 CDD:289560 37/163 (23%)
ANK repeat 672..721 CDD:293786 16/54 (30%)
ANK 721..843 CDD:238125 33/172 (19%)
ANK repeat 723..752 CDD:293786 10/40 (25%)
ANKYR 752..977 CDD:223738 57/315 (18%)
ANK repeat 754..786 CDD:293786 12/70 (17%)
ANK 820..944 CDD:238125 29/156 (19%)
ANK repeat 822..855 CDD:293786 6/33 (18%)
ANK repeat 857..888 CDD:293786 6/30 (20%)
ANK 885..1017 CDD:238125 41/216 (19%)
ANK repeat 890..921 CDD:293786 7/42 (17%)
ANK repeat 923..955 CDD:293786 8/45 (18%)
ANK repeat 996..1021 CDD:293786 10/34 (29%)
FYVE_ANFY1 1054..1116 CDD:277267
Lrrk1NP_001178553.1 ANK 91..214 CDD:238125 29/123 (24%)
ANK repeat 91..119 CDD:293786 8/27 (30%)
Ank_2 126..221 CDD:289560 21/95 (22%)
ANK repeat 156..186 CDD:293786 9/29 (31%)
ANK repeat 188..218 CDD:293786 11/30 (37%)
LRR_RI <273..464 CDD:238064 40/215 (19%)
LRR <279..513 CDD:227223 49/265 (18%)
leucine-rich repeat 281..303 CDD:275380 1/21 (5%)
leucine-rich repeat 304..330 CDD:275380 7/26 (27%)
leucine-rich repeat 331..381 CDD:275380 11/53 (21%)
leucine-rich repeat 382..405 CDD:275380 4/24 (17%)
leucine-rich repeat 406..451 CDD:275380 14/62 (23%)
leucine-rich repeat 452..474 CDD:275380 4/28 (14%)
leucine-rich repeat 475..498 CDD:275380 5/22 (23%)
leucine-rich repeat 499..549 CDD:275380 7/50 (14%)
leucine-rich repeat 550..572 CDD:275380 2/21 (10%)
Gem1 635..>781 CDD:224025 2/5 (40%)
P-loop_NTPase 639..821 CDD:304359 0/1 (0%)
COR 844..1036 CDD:292713
S_TKc 1247..1511 CDD:214567
STKc_LRRK1 1248..1523 CDD:270969
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0192
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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