DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG41099 and Dstyk

DIOPT Version :9

Sequence 1:	NP_001015359.1	Gene:	CG41099 / 3355072	FlyBaseID:	FBgn0039955	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_955750.1	Gene:	Dstyk / 304791	RGDID:	735051	Length:	927	Species:	Rattus norvegicus

Alignment Length:	827	Identity:	167/827 - (20%)
Similarity:	276/827 - (33%)	Gaps:	297/827 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 AVQSDEYTKLQRCYVELQ--RKY------------NENIASS----ENEESGLSSFLSRLSLTVA 65
            |:..||.:  :|...|||  |||            .|.|.||    ::|.|.||..|  :.|...
  Rat   251 ALHKDELS--ERDEQELQEIRKYFSFPVFFFKVPTLEIIRSSSGRADSERSPLSGQL--MDLGYL 311

  Fly    66 SLFDKNTYA-DIYIRSQTRVFPAHKIVLHARSEKWGNDLLSNIQQLDWSDLNEDVVLSLLRWIYT 129
            |...:|..| |...|:|:        :|..:|||        ::||  |..:..:       :.|
  Rat   312 SSSHRNCMASDQDCRAQS--------MLVEQSEK--------LRQL--STFSHQL-------LQT 351

  Fly   130 DLIDLQNDGLALDLLKAAH----------RFGLPSLLGICERALVTSVGVRSCIRFYCVAEEVGA 184
            .|:|      |...|.|.|          .|.:...|.|..:.|.           |...:|
  Rat   352 RLVD------AAKALNAVHSHCLDIFINQAFDMQRDLQITPKRLE-----------YTRKKE--- 396

  Fly   185 STLLEYCSSIISTHWDDLTTDDFQHMSGPLLFEMLKTKTKHPLHAAVRLLREDVVSLCIQKYGNS 249
            :.|.|...:|.:...:::.         .::.|.|.|..:..|..|..:..:||:   :.:.|.:
  Rat   397 NELYESLMNIANRKQEEMK---------DMIVETLNTMKEELLDDAANMEFKDVI---VPENGET 449

  Fly   250 LVNTFSENGILPL-EMALSSKNAKIAKSLVDNGMANINAVNMEGFSLLKSALKNGDAFSANFLLD 313
            :.....::.|..: |:.:|..|..:|..|:.                           |.::|.:
  Rat   450 VGTREIKSCIRQIQELIISRLNQAVANKLIS---------------------------SVDYLRE 487

  Fly   314 ------QNCLLDLPSKPSSDTALHIICNYGPDNTPEIMEVVKKILQRQLNINIQNIKGETPLHIA 372
                  :.||..|  :.|.|.::||..||           :|:||....::.:....|.     :
  Rat   488 SFVGTLERCLQSL--EKSQDVSVHITSNY-----------LKQILNAAYHVEVTFHSGS-----S 534

  Fly   373 IARRNVEMVKLLLK------VPNIDINLRTYDEKCALEL--SLSMGDHEFLIASILLSMGARTDR 429
            :.|...|.:|.:::      .|.|.:.   :..|.|.|.  |||...   |..||......|.:.
  Rat   535 VTRMLWEQIKQIIQRITWVNPPTITLE---WKRKVAQEAIDSLSASK---LAKSICSQFRTRLNS 593

  Fly   430 TNSKTGDSLLQVFALDRHRGEKSAIFLADFADL------DHINFRGLTALHIAALNNM-----PN 483
            ::.....||.|:.|....|.||:       .||      ||.......:|...:|.::     |.
  Rat   594 SHEAFAASLRQLEAGHSGRLEKT-------EDLWLKVRKDHAPRLARLSLESRSLQDVLLHRKPK 651

  Fly   484 LVKKL------IVNGASSNLKHIDCGLKSAL--------HIAVEANAIDAL---EAFVELKNKSH 531
            |.::|      :|....:...|..|.|||.:        .:|:|.:.:.:|   |..|:|....
  Rat   652 LGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSV- 715

  Fly   532 DIDFNCQDINGDSPLSLCLSLKR------TTL-----VPTLIRGGSDVNGKNKNNLSPLH-QSIK 584
             ||:|   ..|.|.:::.|.::|      |.|     :.|.::...||    ...:..|| |.:.
  Rat   716 -IDYN---YGGGSSVAVLLIMERLHRDLYTGLKAGLSLETRLQIALDV----VEGIRFLHSQGLV 772

  Fly   585 NEDSDISLFLLEQ--GADITAL-------------------------TENLDSALDL-------- 614
            :.|..:...||::  .|.||.|                         |...|:::|:
  Rat   773 HRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFW 837

  Fly   615 -----SIKHDLSEVVDALCRRGIALSINKNGESP---------LWSALEKGYEDVAKILVRHGID 665
                 |||  |.|..:....:....:..:.|..|         .|..:|.
  Rat   838 YICSGSIK--LPEAFERCASKDHLWNNVRRGTRPERLPVFDEECWQLMEA--------------- 885

  Fly   666 TDCWDEGPE-----GCRQTLLHRAIDENKESVAIFLIQSQCDLDSSR 707
              |||..|.     |..|.:|...:|.            .|..||.|
  Rat   886 --CWDGDPSKRPLLGIVQPILRSIMDR------------LCKCDSER 918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG41099	NP_001015359.1	BTB	67..164	CDD:279045	22/107 (21%)
		BTB	75..166	CDD:197585	21/100 (21%)
		ANK	252..385	CDD:238125	24/139 (17%)
		ANK repeat	291..322	CDD:293786	5/36 (14%)
		ANK repeat	325..362	CDD:293786	9/36 (25%)
		Ank_2	330..431	CDD:289560	23/108 (21%)
		ANK	463..595	CDD:238125	35/165 (21%)
		ANK repeat	468..501	CDD:293786	7/43 (16%)
		Ank_2	473..572	CDD:289560	29/131 (22%)
		ANK repeat	503..539	CDD:293786	12/46 (26%)
		ANK	536..660	CDD:238125	32/184 (17%)
		ANK repeat	541..572	CDD:293786	9/41 (22%)
		ANK repeat	574..637	CDD:293786	18/103 (17%)
		Ank_2	579..670	CDD:289560	23/140 (16%)
		ANK repeat	639..670	CDD:293786	5/39 (13%)
		Ank_2	644..752	CDD:289560	14/69 (20%)
		ANK repeat	672..721	CDD:293786	9/41 (22%)
		ANK	721..843	CDD:238125
		ANK repeat	723..752	CDD:293786
		ANKYR	752..977	CDD:223738
		ANK repeat	754..786	CDD:293786
		ANK	820..944	CDD:238125
		ANK repeat	822..855	CDD:293786
		ANK repeat	857..888	CDD:293786
		ANK	885..1017	CDD:238125
		ANK repeat	890..921	CDD:293786
		ANK repeat	923..955	CDD:293786
		ANK repeat	996..1021	CDD:293786
		FYVE_ANFY1	1054..1116	CDD:277267
Dstyk	NP_955750.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		PKc_Dusty	649..910	CDD:270877	56/288 (19%)
		S_TKc	651..895	CDD:214567	52/271 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900