DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG41099 and Ankrd17

DIOPT Version :9

Sequence 1:	NP_001015359.1	Gene:	CG41099 / 3355072	FlyBaseID:	FBgn0039955	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	XP_006250825.1	Gene:	Ankrd17 / 289521	RGDID:	1562348	Length:	2640	Species:	Rattus norvegicus

Alignment Length:	826	Identity:	181/826 - (21%)
Similarity:	297/826 - (35%)	Gaps:	177/826 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 GNDLLSNIQQLDWSDLNEDVVLSLLRWIY------------TDLIDLQNDGLALDLLKAAHRFGL 152
            |....:|.::.:..|..|:.|.....|.:            .:...|..|.|...:|:.|.:.
  Rat    94 GGTSSNNSEEEEDDDDEEEEVSEARAWFHLEEGGRDREGPKVESFILDQDDLENPMLETASKL-- 156

  Fly   153 PSLLGICERALVTSVGVRSCIRFYCVAEEVGASTLLEYCSSIISTHWDDLTTDDFQHMSGPLLFE 217
             .|.|..:.|.:.:|...:..|...:.|..|..               .|:|.|.:..:.|.:..
  Rat   157 -LLSGTADGADLRTVDPETQARLEALLEAAGIG---------------KLSTADGKAFADPEVLR 205

  Fly   218 MLKTKTKHPLH---AAVRLLREDVVSLCIQKYGNSLVNTFSENGILPLEMALSSKNAKIAKSLVD 279
            .|.:.....|.   ||:..:|.:..:...|....||....||..:          || :.|.|::
  Rat   206 RLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDV----------NA-VRKLLIE 259

  Fly   280 NGMANINAVNMEGFSLLKSALKNGDAFSANFLLDQNCLLDLPSKPSSDTALHIICNYGPDNTPEI 344
            .  .::|....||.|||..|...|....|..||..:..::........|.|....|.|.
  Rat   260 G--RSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGH------ 316

  Fly   345 MEVVKKILQRQLNINIQNIKGETPLHIAIARRNVEMVKLLLKVPNIDINLRTYDEKCALELSLSM 409
            :::||.:|..:.::|.|:..|.|.|..|.|...|::||:|                  ||...|:
  Rat   317 VKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVL------------------LESGASI 363

  Fly   410 GDH---------------EFLIASILLSMGARTDRTNSKTGDSLLQVFALDRHRGEKSAIFLADF 459
            .||               ...:|.:||..||..:..:::..:|.|.:.....|. |.....|...
  Rat   364 EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHL-EMVRFLLEAG 427

  Fly   460 ADLDHINFRGLTALHIAALNNMPNLVKKLIVNGASSNLKHIDCGLKSALHIAVEANAIDALEAFV 524
            ||.:|......|||..|.::....:.:.|:.:||..|:                  ..|:.|
  Rat   428 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM------------------PADSFE--- 471

  Fly   525 ELKNKSHDIDFNCQDINGDSPLSLCLSLKRTTLVPTLIRGGSDVNGKNKNNLSPLHQSIKNEDSD 589
                               |||:|........|...||..|:.:...|....:||.::.:....:
  Rat   472 -------------------SPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEE 517

  Fly   590 ISLFLLEQGADITALTENL-DSALDLSIKHDLSEVVDALCRRGIALSINKNGESPLWSALEKGYE 653
            :...||.|||:|.|.||.. ::||.|:......||.|.|.:.|..:.:..:  :||..|.::|:.
  Rat   518 MVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS--TPLMEAAQEGHL 580

  Fly   654 DVAKILVRHGIDTDCWDEGPEGCRQTLLHRAIDENKESVAIFLIQSQCDLDSSRQPGPNGEGGDE 718
            ::.|.|:..|.:.    ........|.|..|.:.....||..|:|:..||:.      ..|||
  Rat   581 ELVKYLLAAGANV----HATTATGDTALTYACENGHTDVADVLLQAGADLEH------ESEGG-- 633

  Fly   719 AQDKASPLHLCCHWGQTKVLQTLIDHGANVNLIDAES-KSPLHVAIESQYDEIISILLCH-PDID 781
                .:||......|....:|.||..|||||...|.: .:.|.:|....:..::.:||.| .|..
  Rat   634 ----RTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPT 694

  Fly   782 LKLRD---------KSGNTPFAT-ALDFRNHNAA------------QRILDRFPTAAEQMDIRGR 824
            .:|:|         |.|:|.... .||:.|:..|            ...|:|.|....|.
  Rat   695 HRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLAAPPPDVTQLTPPSHDLNRAPRVPVQA----- 754

  Fly   825 NFLHLAILKDDLESVLFLLAIQVDVNSRVHDANQSSPLHLAAASQN 870
              |.:.:...:.:.....:|..:.|.::. .:.|.|..||.|.||:
  Rat   755 --LPMVVPPQEPDKPPANVAATLPVRNKA-ASKQKSNSHLPANSQD 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG41099	NP_001015359.1	BTB	67..164	CDD:279045	14/75 (19%)
		BTB	75..166	CDD:197585	14/77 (18%)
		ANK	252..385	CDD:238125	34/132 (26%)
		ANK repeat	291..322	CDD:293786	10/30 (33%)
		ANK repeat	325..362	CDD:293786	8/36 (22%)
		Ank_2	330..431	CDD:289560	27/115 (23%)
		ANK	463..595	CDD:238125	22/131 (17%)
		ANK repeat	468..501	CDD:293786	8/32 (25%)
		Ank_2	473..572	CDD:289560	16/98 (16%)
		ANK repeat	503..539	CDD:293786	2/35 (6%)
		ANK	536..660	CDD:238125	33/124 (27%)
		ANK repeat	541..572	CDD:293786	8/30 (27%)
		ANK repeat	574..637	CDD:293786	19/63 (30%)
		Ank_2	579..670	CDD:289560	25/91 (27%)
		ANK repeat	639..670	CDD:293786	7/30 (23%)
		Ank_2	644..752	CDD:289560	29/107 (27%)
		ANK repeat	672..721	CDD:293786	12/48 (25%)
		ANK	721..843	CDD:238125	32/145 (22%)
		ANK repeat	723..752	CDD:293786	11/28 (39%)
		ANKYR	752..977	CDD:223738	30/143 (21%)
		ANK repeat	754..786	CDD:293786	7/33 (21%)
		ANK	820..944	CDD:238125	10/51 (20%)
		ANK repeat	822..855	CDD:293786	3/32 (9%)
		ANK repeat	857..888	CDD:293786	7/14 (50%)
		ANK	885..1017	CDD:238125
		ANK repeat	890..921	CDD:293786
		ANK repeat	923..955	CDD:293786
		ANK repeat	996..1021	CDD:293786
		FYVE_ANFY1	1054..1116	CDD:277267
Ankrd17	XP_006250825.1	Ank_2	241..333	CDD:289560	26/110 (24%)
		ANK repeat	241..267	CDD:293786	8/38 (21%)
		ANK	264..390	CDD:238125	35/149 (23%)
		ANK repeat	269..301	CDD:293786	10/31 (32%)
		ANK repeat	306..334	CDD:293786	8/33 (24%)
		Ank_2	308..397	CDD:289560	27/112 (24%)
		ANK	331..457	CDD:238125	33/144 (23%)
		ANK repeat	336..367	CDD:293786	13/48 (27%)
		ANK repeat	369..397	CDD:293786	5/27 (19%)
		ANK	399..523	CDD:238125	29/164 (18%)
		ANK repeat	403..434	CDD:293786	8/31 (26%)
		Ank_4	406..457	CDD:290365	12/51 (24%)
		ANK repeat	438..467	CDD:293786	8/46 (17%)
		Ank_2	441..532	CDD:289560	25/130 (19%)
		ANK repeat	469..500	CDD:293786	9/52 (17%)
		ANK repeat	502..532	CDD:293786	8/29 (28%)
		ANK repeat	535..564	CDD:293786	8/28 (29%)
		Ank_4	539..587	CDD:290365	13/49 (27%)
		ANK	569..687	CDD:238125	33/133 (25%)
		ANK repeat	569..597	CDD:293786	7/31 (23%)
		Ank_2	571..662	CDD:289560	29/106 (27%)
		ANK repeat	599..630	CDD:293786	9/36 (25%)
		ANK repeat	632..661	CDD:293786	12/34 (35%)
		Ank_2	637..726	CDD:289560	25/88 (28%)
		ANK	665..>739	CDD:238125	15/73 (21%)
		ANK repeat	666..696	CDD:293786	6/29 (21%)
		OmpH	797..>896	CDD:281871	0/1 (0%)
		AhaH	808..884	CDD:131972
		ANKYR	1074..1300	CDD:223738
		ANK	1110..1138	CDD:197603
		ANK repeat	1112..1141	CDD:293786
		ANK	1139..1266	CDD:238125
		ANK repeat	1143..1175	CDD:293786
		ANK repeat	1177..1208	CDD:293786
		ANK repeat	1210..1241	CDD:293786
		ANK repeat	1245..1275	CDD:293786
		ANK repeat	1278..1310	CDD:293786
		ANK	1308..1434	CDD:238125
		ANK repeat	1312..1341	CDD:293786
		Ank_2	1317..1411	CDD:289560
		ANK repeat	1349..1378	CDD:293786
		ANK repeat	1380..1411	CDD:293786
		NusA	<1748..1795	CDD:223273
		KH-I	1755..1817	CDD:238053
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1115202at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010