DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG41099 and ANK3

DIOPT Version :9

Sequence 1:	NP_001015359.1	Gene:	CG41099 / 3355072	FlyBaseID:	FBgn0039955	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_066267.2	Gene:	ANK3 / 288	HGNCID:	494	Length:	4377	Species:	Homo sapiens

Alignment Length:	870	Identity:	226/870 - (25%)
Similarity:	347/870 - (39%)	Gaps:	211/870 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   227 LHAAVRLLREDVVSLCIQKYGNSLVNTFSENGILPLEMALSSKNAKIAKSLVDNGMANINAVNME 291
            ||.|....:.:||.:.:....|  ||..|:||..||.||....:.::.|.|:||| |:.:....:
Human   111 LHIASLAGQAEVVKVLVTNGAN--VNAQSQNGFTPLYMAAQENHLEVVKFLLDNG-ASQSLATED 172

  Fly   292 GFSLLKSALKNG-----------------------------DAFSANFLLDQNCLLDLPSKPSSD 327
            ||:.|..||:.|                             |..:|..||..:...|:.|| |..
Human   173 GFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESK-SGF 236

  Fly   328 TALHIICNYGPDNTPEIMEVVKKILQRQLNINIQNIKGETPLHIAIARRNVEMVKLLLKVPNIDI 392
            |.|||..:||..|      |...:|.|...::.......||||:|..|.|..||||||. ....|
Human   237 TPLHIAAHYGNIN------VATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLD-RGAKI 294

  Fly   393 NLRTYDEKCALELSLSMGDHEFLIASILLSMGARTDRTN---SKT------------GDSLLQVF 442
            :.:|.|....|......| ||.::..:|       ||..   |||            ||.|..|.
Human   295 DAKTRDGLTPLHCGARSG-HEQVVEMLL-------DRAAPILSKTKNGLSPLHMATQGDHLNCVQ 351

  Fly   443 ALDRHRGEKSAIFLADFADLDHINFRGLTALHIAALNNMPNLVKKLIVNGASSNLKHIDCGLKSA 507
            .|.:|.           ..:|.:....|||||:||......:.|.|:...|:.|.|.:: |. :.
Human   352 LLLQHN-----------VPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALN-GF-TP 403

  Fly   508 LHIAVEANAIDALE------AFVELKNKS----------------------HDIDFNCQDINGDS 544
            ||||.:.|.|..:|      |.::...:|                      |....|..::.|::
Human   404 LHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGET 468

  Fly   545 PLSLCLSLKRTTLVPTLIRGGSDVNGKNKNNLSPLHQSIKNEDSDISLFLLEQGADITALTENLD 609
            .|.:.....:..:|..|::.|:.|..|.|::.:|||.|.:...:||...||:|||...|.|.:..
Human   469 ALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGY 533

  Fly   610 SALDLSIKHDLSEVVDALCRRGIALSI-NKNGESPLWSALEKGYEDVAKILVRHGIDTDCWDEGP 673
            :.|.||.:....:|...|...|.:||| .|.|.:||..|.:.|..:||.:|::.....|.  .|.
Human   534 TPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDA--AGK 596

  Fly   674 EGCRQTLLHRAIDENKESVAIFLIQSQCDLDSSRQPGPNGEGGDEAQDKASPLHLCCHWGQTKVL 738
            .|.  |.||.|...:.:.||:.|      ||....|....:.|      .:|||:.....|..:.
Human   597 SGL--TPLHVAAHYDNQKVALLL------LDQGASPHAAAKNG------YTPLHIAAKKNQMDIA 647

  Fly   739 QTLIDHGANVNLIDAESKSPLHVAIESQYDEIISILLCHPDIDLKLRDKSGNTPFATALDFRNHN 803
            .||:::||:.|.:..:..:.:|:|.:..:.:::|:||.. :.::.|.:|||.||
Human   648 TTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGR-NANVNLSNKSGLTP----------- 700

  Fly   804 AAQRILDRFPTAAEQMDIRGRNFLHLAILKDDLESVLFLLAIQVDVNSRVH-DANQS---SPLHL 864
                                   ||||..:|.:.      ..:|.||...| ||...   :|||:
Human   701 -----------------------LHLAAQEDRVN------VAEVLVNQGAHVDAQTKMGYTPLHV 736

  Fly   865 AAASQNEMITRNLILAGARMNERDAVQKLPLHIAIERGNLPAVSALIQNNADYDATDADGNNALH 929
            .....|..|...|:...|::|.:......|||.|.::|:...::.|:||||..:....:||.||.
Human   737 GCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALG 801

  Fly   930 IAVRCAQFFIV--RELLTESRVNAEATNLKGRNPLHELCRVVEDSTAGLICELFLESMPKYPINI 992
            ||.|.....:|  .:::||                       |..|...:.|       |:.:|:
Human   802 IARRLGYISVVDTLKIVTE-----------------------ETMTTTTVTE-------KHKMNV 836

  Fly   993 P-------DMD------GNTPLLLS 1004
            |       ||.      .|.|.:||
Human   837 PETMNEVLDMSDDEVRKANAPEMLS 861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG41099	NP_001015359.1	BTB	67..164	CDD:279045
		BTB	75..166	CDD:197585
		ANK	252..385	CDD:238125	49/161 (30%)
		ANK repeat	291..322	CDD:293786	11/59 (19%)
		ANK repeat	325..362	CDD:293786	11/36 (31%)
		Ank_2	330..431	CDD:289560	32/100 (32%)
		ANK	463..595	CDD:238125	39/159 (25%)
		ANK repeat	468..501	CDD:293786	12/32 (38%)
		Ank_2	473..572	CDD:289560	27/126 (21%)
		ANK repeat	503..539	CDD:293786	12/63 (19%)
		ANK	536..660	CDD:238125	39/124 (31%)
		ANK repeat	541..572	CDD:293786	6/30 (20%)
		ANK repeat	574..637	CDD:293786	22/63 (35%)
		Ank_2	579..670	CDD:289560	31/91 (34%)
		ANK repeat	639..670	CDD:293786	9/30 (30%)
		Ank_2	644..752	CDD:289560	29/107 (27%)
		ANK repeat	672..721	CDD:293786	13/48 (27%)
		ANK	721..843	CDD:238125	25/121 (21%)
		ANK repeat	723..752	CDD:293786	9/28 (32%)
		ANKYR	752..977	CDD:223738	52/230 (23%)
		ANK repeat	754..786	CDD:293786	6/31 (19%)
		ANK	820..944	CDD:238125	37/129 (29%)
		ANK repeat	822..855	CDD:293786	9/33 (27%)
		ANK repeat	857..888	CDD:293786	8/33 (24%)
		ANK	885..1017	CDD:238125	33/135 (24%)
		ANK repeat	890..921	CDD:293786	10/30 (33%)
		ANK repeat	923..955	CDD:293786	10/33 (30%)
		ANK repeat	996..1021	CDD:293786	4/15 (27%)
		FYVE_ANFY1	1054..1116	CDD:277267
ANK3	NP_066267.2	ANK 6	234..263		11/34 (32%)
		ANK repeat	267..298	CDD:293786	14/31 (45%)
		ANK 7	267..296		14/29 (48%)
		Ank_2	272..363	CDD:289560	31/110 (28%)
		ANK	295..420	CDD:238125	39/145 (27%)
		ANK 8	300..329		8/36 (22%)
		ANK repeat	300..325	CDD:293786	8/32 (25%)
		ANK repeat	333..364	CDD:293786	7/41 (17%)
		ANK 9	333..362		6/39 (15%)
		ANK	361..486	CDD:238125	28/126 (22%)
		ANK 10	366..395		10/28 (36%)
		ANK repeat	369..397	CDD:293786	10/27 (37%)
		Ank_2	371..463	CDD:289560	21/93 (23%)
		ANK repeat	399..430	CDD:293786	9/32 (28%)
		ANK 11	399..428		9/30 (30%)
		ANK repeat	432..463	CDD:293786	3/30 (10%)
		ANK 12	432..461		2/28 (7%)
		ANK	460..585	CDD:238125	39/124 (31%)
		ANK repeat	465..496	CDD:293786	6/30 (20%)
		ANK 13	465..494		6/28 (21%)
		Ank_2	470..561	CDD:289560	28/90 (31%)
		ANK repeat	498..529	CDD:293786	12/30 (40%)
		ANK 14	498..527		11/28 (39%)
		ANK repeat	531..560	CDD:293786	7/28 (25%)
		ANK 15	531..560		7/28 (25%)
		Ank_2	536..626	CDD:289560	31/99 (31%)
		ANK	560..684	CDD:238125	36/139 (26%)
		ANK repeat	564..593	CDD:293786	8/28 (29%)
		ANK 16	564..593		8/28 (29%)
		ANK repeat	597..626	CDD:293786	11/36 (31%)
		ANK 17	597..626		11/36 (31%)
		ANK repeat	630..660	CDD:293786	10/35 (29%)
		ANK 18	630..659		9/34 (26%)
		Ank_4	631..684	CDD:290365	13/58 (22%)
		ANK	658..783	CDD:238125	36/165 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44
		Ank_4	47..94	CDD:290365
		ANK	68..193	CDD:238125	27/84 (32%)
		ANK repeat	73..104	CDD:293786
		ANK 1	73..102
		Ank_2	78..164	CDD:289560	20/55 (36%)
		ANK repeat	106..137	CDD:293786	8/27 (30%)
		ANK 2	106..135		7/25 (28%)
		ANK 3	139..168		12/29 (41%)
		ANK repeat	139..164	CDD:293786	11/25 (44%)
		Ank_4	140..193	CDD:290365	17/53 (32%)
		ANK 4	172..201		6/28 (21%)
		ANK 5	203..230		4/26 (15%)
		ANK repeat	205..232	CDD:293786	5/26 (19%)
		Ank_2	206..297	CDD:289560	32/98 (33%)
		ANK	229..354	CDD:238125	44/140 (31%)
		ANK repeat	234..265	CDD:293786	11/36 (31%)
		ANK repeat	663..694	CDD:293786	6/31 (19%)
		ANK 19	663..692		5/29 (17%)
		Ank_2	669..759	CDD:289560	30/130 (23%)
		ANK repeat	696..727	CDD:293786	15/70 (21%)
		ANK 20	696..725		13/68 (19%)
		ANK repeat	729..760	CDD:293786	8/30 (27%)
		ANK 21	729..758		7/28 (25%)
		Ank_5	749..803	CDD:290568	17/53 (32%)
		ANK 22	762..791		10/28 (36%)
		ANK repeat	762..790	CDD:293786	10/27 (37%)
		ANK 23	795..825		11/52 (21%)
		ZU5	982..1086	CDD:128514
UPA domain. /evidence=ECO:0000250	1273..1407
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1519..1540
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1968..1987
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2107..2159
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2176..2245
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2299..2322
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2383..2433
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2474..2508
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2588..2751
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2795..2824
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3036..3067
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3131..3272
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3298..3516
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3538..3607
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3635..3718
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3868..3897
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4019..4090
Death_ank3	4088..4171	CDD:176781
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4251..4298
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4323..4377
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	2	1.870