DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG41099 and ANK2

DIOPT Version :9

Sequence 1:	NP_001015359.1	Gene:	CG41099 / 3355072	FlyBaseID:	FBgn0039955	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_001373103.1	Gene:	ANK2 / 287	HGNCID:	493	Length:	4183	Species:	Homo sapiens

Alignment Length:	1028	Identity:	249/1028 - (24%)
Similarity:	387/1028 - (37%)	Gaps:	290/1028 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 YADIYIRSQTRVFPAHKIVLHARSEKWGNDLLSNIQQLD------------------WSDLNEDV 119
            :||..||:|                       .|:|:||                  |||.|
Human    11 HADKSIRAQ-----------------------GNMQELDKTPDYYGCNSEDVKEPGVWSDSN--- 49

  Fly   120 VLSLLRWIYTDLIDLQNDGLALDLLKAAHRFGLPSLLGICERALVTSVGVRSCIR-----FYCVA 179
                                 ...|:||....|..::    ..|...:.:.:|.:     .:..|
Human    50 ---------------------ASFLRAARAGNLDKVV----EYLKGGIDINTCNQNGLNALHLAA 89

  Fly   180 EE--VG-ASTLLEYCSSIISTHWDDLTTDDFQHMSGPLLFEMLKTKTKHPLHAAVRLLREDVVSL 241
            :|  || ...||...||:     |..|                 .|....||.|....:.:||.:
Human    90 KEGHVGLVQELLGRGSSV-----DSAT-----------------KKGNTALHIASLAGQAEVVKV 132

  Fly   242 CIQKYGNSLVNTFSENGILPLEMALSSKNAKIAKSLVDNGMANINAVNMEGFSLLKSALKNG--- 303
            .:::..|  :|..|:||..||.||....:..:.|.|::|| ||.:....:||:.|..||:.|
Human   133 LVKEGAN--INAQSQNGFTPLYMAAQENHIDVVKYLLENG-ANQSTATEDGFTPLAVALQQGHNQ 194

  Fly   304 --------------------------DAFSANFLLDQNCLLDLPSK-------PSSDTALHIICN 335
                                      |..||..||..:...|:.||       .|..|.|||..:
Human   195 AVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAH 259

  Fly   336 YGPDNTPEIMEVVKKILQRQLNINIQNIKGETPLHIAIARRNVEMVKLLLKVPNIDINLRTYDEK 400
            ||..|      |...:|.|...::.....|.||||:|..|.|..||||||.... .|:.:|.|..
Human   260 YGNVN------VATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGG-QIDAKTRDGL 317

  Fly   401 CALELSLSMGDHEFLIASILLSMG----ARTDRTNSKTGDSLLQVFALDRHRGEKSAIFLADFAD 461
            ..|..:...|..:  :..:||..|    |||     |.|.|.|.:.|...| .|.....|...|.
Human   318 TPLHCAARSGHDQ--VVELLLERGAPLLART-----KNGLSPLHMAAQGDH-VECVKHLLQHKAP 374

  Fly   462 LDHINFRGLTALHIAALNNMPNLVKKLIVNGASSNLKHIDCGLKSALHIAVEANAIDALEAFVE- 525
            :|.:....|||||:||......:.|.|:...|:.|.:.:: |. :.||||.:.|.|..:|..|:
Human   375 VDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALN-GF-TPLHIACKKNRIKVMELLVKY 437

  Fly   526 ------------------------------LKN-KSHDIDFNCQDINGDSPLSLCLSLKRTTLVP 559
                                          |:| .|.|:    .:|.|::.|.:.....:..:|.
Human   438 GASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV----TNIRGETALHMAARAGQVEVVR 498

  Fly   560 TLIRGGSDVNGKNKNNLSPLHQSIKNEDSDISLFLLEQGADITALTENLDSALDLSIKHDLSEVV 624
            .|:|.|:.|:.:.:...:|||.:.:...::|...||:..|...|.|.|..:.|.:|.:....:|.
Human   499 CLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVA 563

  Fly   625 DALCRRGIALSI-NKNGESPLWSALEKGYEDVAKILVRHGIDTDCWDEGPEGCRQTLLHRAIDEN 688
            ..|...|.|.|: .|.|.:||..|.:.|..||||:|::.....|  ..|..|.  |.||.|...:
Human   564 SVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD--SAGKNGL--TPLHVAAHYD 624

  Fly   689 KESVAIFLIQSQCDLDSSRQPGPNGEGGDEAQDKASPLHLCCHWGQTKVLQTLIDHGANVNLIDA 753
            .:.||:.|      |:....|....:.|      .:|||:.....|.::..||:::||..|::..
Human   625 NQKVALLL------LEKGASPHATAKNG------YTPLHIAAKKNQMQIASTLLNYGAETNIVTK 677

  Fly   754 ESKSPLHVAIESQYDEIISILLCHPDIDLKLRDKSGNTPFATALDFRNHNAAQRILDRFPTAAEQ 818
            :..:|||:|.:..:.:::::||          ||..|...:|.
Human   678 QGVTPLHLASQEGHTDMVTLLL----------DKGANIHMSTK---------------------- 710

  Fly   819 MDIRGRNFLHLAILKDDLESVLFLLAIQVDVNSRVHDANQS-------SPLHLAAASQNEMITRN 876
               .|...||||..:|.:.        ..|:.:: |.|:|.       :||.:|....|..:...
Human   711 ---SGLTSLHLAAQEDKVN--------VADILTK-HGADQDAHTKLGYTPLIVACHYGNVKMVNF 763

  Fly   877 LILAGARMNERDAVQKLPLHIAIERGNLPAVSALIQNNADYDATDADGNNALHIAVRCAQFFIVR 941
            |:..||.:|.:......|||.|.::|:...::.|:|:.|..:||.|:||.||.||.|.....:|.
Human   764 LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVD 828

  Fly   942 ELLTESRVNAEATNLKGRNPLHELCRVVEDSTAGLICELFLESMPKYPINIPD 994
            .|..   |..|.|                 :|...|.|       |:.:|:|:
Human   829 TLKV---VTEEVT-----------------TTTTTITE-------KHKLNVPE 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG41099	NP_001015359.1	BTB	67..164	CDD:279045	17/108 (16%)
		BTB	75..166	CDD:197585	17/108 (16%)
		ANK	252..385	CDD:238125	51/168 (30%)
		ANK repeat	291..322	CDD:293786	12/59 (20%)
		ANK repeat	325..362	CDD:293786	11/36 (31%)
		Ank_2	330..431	CDD:289560	34/104 (33%)
		ANK	463..595	CDD:238125	37/163 (23%)
		ANK repeat	468..501	CDD:293786	11/32 (34%)
		Ank_2	473..572	CDD:289560	29/130 (22%)
		ANK repeat	503..539	CDD:293786	13/67 (19%)
		ANK	536..660	CDD:238125	35/124 (28%)
		ANK repeat	541..572	CDD:293786	7/30 (23%)
		ANK repeat	574..637	CDD:293786	17/63 (27%)
		Ank_2	579..670	CDD:289560	28/91 (31%)
		ANK repeat	639..670	CDD:293786	11/30 (37%)
		Ank_2	644..752	CDD:289560	30/107 (28%)
		ANK repeat	672..721	CDD:293786	12/48 (25%)
		ANK	721..843	CDD:238125	25/121 (21%)
		ANK repeat	723..752	CDD:293786	9/28 (32%)
		ANKYR	752..977	CDD:223738	52/231 (23%)
		ANK repeat	754..786	CDD:293786	6/31 (19%)
		ANK	820..944	CDD:238125	37/130 (28%)
		ANK repeat	822..855	CDD:293786	7/32 (22%)
		ANK repeat	857..888	CDD:293786	9/37 (24%)
		ANK	885..1017	CDD:238125	30/110 (27%)
		ANK repeat	890..921	CDD:293786	9/30 (30%)
		ANK repeat	923..955	CDD:293786	11/31 (35%)
		ANK repeat	996..1021	CDD:293786
		FYVE_ANFY1	1054..1116	CDD:277267
ANK2	NP_001373103.1	Ank_2	35..>311	CDD:423045	81/335 (24%)
		ANK repeat	80..111	CDD:293786	9/35 (26%)
		ANK repeat	113..144	CDD:293786	8/32 (25%)
		ANK repeat	146..171	CDD:293786	10/25 (40%)
		Ank_2	202..>444	CDD:423045	74/258 (29%)
		ANK repeat	212..247	CDD:293786	8/34 (24%)
		ANK repeat	249..280	CDD:293786	11/36 (31%)
		ANK repeat	282..313	CDD:293786	15/31 (48%)
		ANK repeat	315..345	CDD:293786	6/31 (19%)
		ANK repeat	348..379	CDD:293786	9/31 (29%)
		ANK repeat	381..411	CDD:293786	11/29 (38%)
		ANK repeat	414..445	CDD:293786	9/32 (28%)
		PHA03095	421..>706	CDD:222980	77/314 (25%)
		ANK repeat	447..478	CDD:293786	4/34 (12%)
		ANK repeat	480..511	CDD:293786	7/30 (23%)
		ANK repeat	513..542	CDD:293786	7/28 (25%)
		ANK repeat	546..571	CDD:293786	5/24 (21%)
		Ank_2	578..>802	CDD:423045	68/283 (24%)
		ANK repeat	579..604	CDD:293786	10/24 (42%)
		ANK repeat	612..643	CDD:293786	10/38 (26%)
		ANK repeat	645..676	CDD:293786	10/36 (28%)
		ANK repeat	678..707	CDD:293786	9/38 (24%)
		ANK repeat	711..742	CDD:293786	10/39 (26%)
		ANK repeat	744..775	CDD:293786	8/30 (27%)
		ANK repeat	777..806	CDD:293786	8/28 (29%)
		Ank_4	778..830	CDD:372654	19/51 (37%)
		ZU5	1013..1150	CDD:128514
		UPA_2	1371..1500	CDD:375346
		PspC_subgroup_1	1549..>1922	CDD:411407
		PTZ00449	<1717..2161	CDD:185628
		Streccoc_I_II	<1843..>2027	CDD:411384
		Spc7_N	<2493..>2634	CDD:373822
		rad2	<3031..>3565	CDD:273166
		PRK14949	<3196..>3442	CDD:237863
		Death_ank2	3614..3697	CDD:260066
		NESP55	<3770..>3884	CDD:115071
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	2	1.870