DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG41099 and ANK1

DIOPT Version :9

Sequence 1:	NP_001015359.1	Gene:	CG41099 / 3355072	FlyBaseID:	FBgn0039955	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	XP_011542792.1	Gene:	ANK1 / 286	HGNCID:	492	Length:	1969	Species:	Homo sapiens

Alignment Length:	890	Identity:	216/890 - (24%)
Similarity:	372/890 - (41%)	Gaps:	164/890 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   227 LHAAVRLLREDV-VSLCIQKYGNSLVNTF------SENGILPLEMALSSKNAKIAKSLVDNGMAN 284
            |..|:..||..| ::.|.|....|.|:..      ...|:|   ..|.::|.|      .||:..
Human    58 LDKALDHLRNGVDINTCNQGPSASAVDLLLRCRISQSTGLL---RVLYNQNRK------KNGLNG 113

  Fly   285 INAVNMEGFSLLKSALKNGDAFSANFLLDQNCLLDLPSKPSSDTALHIICNYGPDNTPEIMEVVK 349
            ::..:.||.  :|..::         ||.:..:|:..:| ..:|||||....|.|      |||:
Human   114 LHLASKEGH--VKMVVE---------LLHKEIILETTTK-KGNTALHIAALAGQD------EVVR 160

  Fly   350 KILQRQLNINIQNIKGETPLHIAIARRNVEMVKLLLKVPNIDINLRTYDEKCALELSLSMGDHEF 414
            :::....|:|.|:.||.|||::|....::|:||.||: ...:.|:.|.|....|.::|..| ||.
Human   161 ELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE-NGANQNVATEDGFTPLAVALQQG-HEN 223

  Fly   415 LIASIL------------LSMGARTDRTNSKTGDSLLQVFALDRHRGEKSAIFLADFADLDHINF 467
            ::|.::            |.:.||.|.|.:                   :|:.|.:..:.|.::.
Human   224 VVAHLINYGTKGKVRLPALHIAARNDDTRT-------------------AAVLLQNDPNPDVLSK 269

  Fly   468 RGLTALHIAALNNMPNLVKKLIVNGASSNLKHIDCGLKSALHIAVEANAIDALE------AFVEL 526
            .|.|.|||||.....|:.:.|:..|||.|....: |: :.||||.....:..:.      |.:|.
Human   270 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN-GI-TPLHIASRRGNVIMVRLLLDRGAQIET 332

  Fly   527 KNKSHDIDFNCQDINGDSPLSLCLSLKRTTLVPTLIRGGSDVNGKNKNNLSPLHQSIKNEDSDIS 591
            |.|......:|...||...:|           ..|:..|:.:..|.||.|||:|.:.:.:..|..
Human   333 KTKDELTPLHCAARNGHVRIS-----------EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCV 386

  Fly   592 LFLLEQGADITALTEN--------------------LD-------------SALDLSIKHDLSEV 623
            ..||:..|:|..:|.:                    ||             :.|.::.|.:...|
Human   387 RLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRV 451

  Fly   624 VDALCRRGIAL-SINKNGESPLWSALEKGYEDVAKILVRHGIDTDCWDEGPEGCRQTLLHRAIDE 687
            ::.|.:.|.:: ::.::|.:||..|...|:..:.|.|::.|...:..:...|    |.||.|...
Human   452 MELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE----TPLHMAARA 512

  Fly   688 NKESVAIFLIQSQCDLDSSRQPGPNGEGGDEAQDKASPLHLCCHWGQTKVLQTLIDHGANVNLID 752
            ....||.:|:|::..:::            :|:|..:|||.....|.|.:::.|:::.||.||..
Human   513 GHTEVAKYLLQNKAKVNA------------KAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 565

  Fly   753 AESKSPLHVAIESQYDEIISILLCHPDIDLKLRDKSGNTPFATALDFRNHNAAQRILDR--FPTA 815
            ....:|||:|....:.|.:..|| ..:.......|.|.||...|..:.....|:.:|:|  .|.|
Human   566 TAGHTPLHIAAREGHVETVLALL-EKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA 629

  Fly   816 AEQMDIRGRNFLHLAILKDDLESVLFLLAIQVDVNSRVHDANQSSPLHLAAASQNEMITRNLILA 880
            |.:   .|...||:|:..::|:.|..||......:|...  |..:|||:||......:.|:|:..
Human   630 AGK---NGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW--NGYTPLHIAAKQNQVEVARSLLQY 689

  Fly   881 GARMNERDAVQKLPLHIAIERGNLPAVSALIQNNADYDATDADGNNALHIAVRCAQFFIVRELLT 945
            |...|........|||:|.:.|:...|:.|:...|:.:..:..|...||:..: .....|.::|.
Human   690 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQ-EGHVPVADVLI 753

  Fly   946 ESRVNAEATNLKGRNPLHELCRVVEDSTAGLICELFLESMPKYPINIPDMDGNTPLLLSFMRGQS 1010
            :..|..:||...|..|||     |......:....|| ...:..:|.....|.:||..:..:|.:
Human   754 KHGVMVDATTRMGYTPLH-----VASHYGNIKLVKFL-LQHQADVNAKTKLGYSPLHQAAQQGHT 812

  Fly  1011 PLCKILVKAGACLGTENKDG------------INIFN-FKLATDQ 1042
            .:..:|:|.||.....:.||            |::.: .|:.||:
Human   813 DIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDE 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG41099	NP_001015359.1	BTB	67..164	CDD:279045
		BTB	75..166	CDD:197585
		ANK	252..385	CDD:238125	36/138 (26%)
		ANK repeat	291..322	CDD:293786	6/30 (20%)
		ANK repeat	325..362	CDD:293786	12/36 (33%)
		Ank_2	330..431	CDD:289560	35/112 (31%)
		ANK	463..595	CDD:238125	37/137 (27%)
		ANK repeat	468..501	CDD:293786	13/32 (41%)
		Ank_2	473..572	CDD:289560	26/104 (25%)
		ANK repeat	503..539	CDD:293786	10/41 (24%)
		ANK	536..660	CDD:238125	32/157 (20%)
		ANK repeat	541..572	CDD:293786	5/30 (17%)
		ANK repeat	574..637	CDD:293786	18/96 (19%)
		Ank_2	579..670	CDD:289560	22/124 (18%)
		ANK repeat	639..670	CDD:293786	8/30 (27%)
		Ank_2	644..752	CDD:289560	27/107 (25%)
		ANK repeat	672..721	CDD:293786	10/48 (21%)
		ANK	721..843	CDD:238125	35/123 (28%)
		ANK repeat	723..752	CDD:293786	10/28 (36%)
		ANKYR	752..977	CDD:223738	58/226 (26%)
		ANK repeat	754..786	CDD:293786	7/31 (23%)
		ANK	820..944	CDD:238125	31/123 (25%)
		ANK repeat	822..855	CDD:293786	9/32 (28%)
		ANK repeat	857..888	CDD:293786	10/30 (33%)
		ANK	885..1017	CDD:238125	29/131 (22%)
		ANK repeat	890..921	CDD:293786	8/30 (27%)
		ANK repeat	923..955	CDD:293786	7/31 (23%)
		ANK repeat	996..1021	CDD:293786	6/24 (25%)
		FYVE_ANFY1	1054..1116	CDD:277267
ANK1	XP_011542792.1	ANK	47..163	CDD:238125	33/131 (25%)
		ANK repeat	47..75	CDD:293786	5/16 (31%)
		ANK	108..229	CDD:238125	42/140 (30%)
		ANK repeat	109..140	CDD:293786	8/41 (20%)
		Ank_2	114..204	CDD:289560	31/108 (29%)
		ANK repeat	143..173	CDD:293786	12/35 (34%)
		ANK	170..324	CDD:238125	48/176 (27%)
		ANK repeat	175..206	CDD:293786	12/31 (39%)
		ANK repeat	208..232	CDD:293786	7/24 (29%)
		ANK repeat	241..268	CDD:293786	8/45 (18%)
		Ank_2	242..333	CDD:289560	28/111 (25%)
		ANK	265..390	CDD:238125	37/137 (27%)
		ANK repeat	271..301	CDD:293786	13/29 (45%)
		ANK repeat	303..334	CDD:293786	7/32 (22%)
		Ank_2	308..397	CDD:289560	25/99 (25%)
		ANK repeat	336..367	CDD:293786	6/41 (15%)
		ANK repeat	369..400	CDD:293786	10/30 (33%)
		Ank	402..432	CDD:278452	2/29 (7%)
		ANK repeat	405..433	CDD:293786	2/27 (7%)
		ANKYR	406..619	CDD:223738	49/229 (21%)
		ANK	430..555	CDD:238125	29/140 (21%)
		ANK repeat	435..466	CDD:293786	5/30 (17%)
		ANK repeat	468..499	CDD:293786	8/30 (27%)
		ANK repeat	501..532	CDD:293786	9/46 (20%)
		ANK	529..654	CDD:238125	36/140 (26%)
		ANK repeat	534..563	CDD:293786	9/28 (32%)
		ANK repeat	568..598	CDD:293786	7/30 (23%)
		ANK repeat	600..631	CDD:293786	9/30 (30%)
		Ank_2	605..696	CDD:289560	26/95 (27%)
		ANK repeat	633..661	CDD:293786	8/27 (30%)
		ANK repeat	666..697	CDD:293786	10/30 (33%)
		ANK	666..695	CDD:197603	9/28 (32%)
		ANK	694..819	CDD:238125	29/131 (22%)
		ANK repeat	699..730	CDD:293786	8/30 (27%)
		Ank_2	704..795	CDD:289560	23/97 (24%)
		ANK repeat	732..763	CDD:293786	7/31 (23%)
		ANK repeat	765..796	CDD:293786	8/36 (22%)
		Ank_5	785..839	CDD:290568	12/54 (22%)
		ANK repeat	798..826	CDD:293786	8/27 (30%)
		ZU5	984..1088	CDD:128514
		Death_ank1	1474..1557	CDD:260067
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	2	1.870