DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG41099 and ANKK1

DIOPT Version :9

Sequence 1:NP_001015359.1 Gene:CG41099 / 3355072 FlyBaseID:FBgn0039955 Length:1124 Species:Drosophila melanogaster
Sequence 2:XP_011541038.1 Gene:ANKK1 / 255239 HGNCID:21027 Length:776 Species:Homo sapiens


Alignment Length:919 Identity:197/919 - (21%)
Similarity:323/919 - (35%) Gaps:311/919 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   217 EMLKTKTKHPLHAAVRLLREDVVSLCIQKYGNSLVNTFSENGILPLEMALSSKNAKIAKSLVDNG 281
            :|.|.|.:|.:         .:..:|.|..|  :|..|..||.|...::..|...|:...::...
Human    74 KMKKIKFQHIV---------SIYGVCKQPLG--IVMEFMANGSLEKVLSTHSLCWKLRFRIIHET 127

  Fly   282 MANINAVNMEGFSLLKSALKNGDAFSANFLLDQNCLLDLPSKPSSDTALHI-ICNYG----PDNT 341
            ...:|.::.....||...||.|     |.|||.|              :|: |.::|    .:.:
Human   128 SLAMNFLHSIKPPLLHLDLKPG-----NILLDSN--------------MHVKISDFGLSKWMEQS 173

  Fly   342 PEIMEVVKKILQRQLN-----INIQNIKGETPLH----IAIA--------------------RRN 377
            ..:..:.:..|:..|:     :.:::.|...|.:    .||.                    |:.
Human   174 TRMQYIERSALRGMLSYIPPEMFLESNKAPGPKYDVYSFAIVIWELLTQKKPYSELTSQLKERKG 238

  Fly   378 VEMVKLLLKV---------------PN-----IDINLRTYDE-----KCALELSLSMGDHEFLIA 417
            ..|:.::::|               |:     :|:..|.:|:     .|.|::::.        .
Human   239 FNMMMIIIRVAAGMRPSLQPVSDQWPSEAQQMVDLMKRCWDQDPKKRPCFLDITIE--------T 295

  Fly   418 SILLS-MGARTDRTNSKTGDSLLQVFALDRHRGEKSAIF---LADFADLDHINFRGLTALHIAAL 478
            .|||| :.:|.....||.....:......|..||.:...   |.|.||..:...|.|      .|
Human   296 DILLSLLQSRVAVPESKALARKVSCKLSLRQPGEVNEDISQELMDSADSGNYLKRAL------QL 354

  Fly   479 NNMPNLVKK-----LIVNGASSNLKHIDCGLKSALHIAVEANAIDALEAFVELKNKSHDIDFNCQ 538
            ::..|||.:     :..|..            :.||..|...:::.:...:     :|::|.:||
Human   355 SDRKNLVPRDEELCIYENKV------------TPLHFLVAQGSVEQVRLLL-----AHEVDVDCQ 402

  Fly   539 DINGDSPLSLCLSLKRTTLVPTLIRGGSDVNGKNKNNLSPLHQSIKNEDSDISLFLLEQGADITA 603
            ..:|.:||.:....::..|...|:..|:|.|..:::..:|||.:.:|.|...:..||:.||    
Human   403 TASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGA---- 463

  Fly   604 LTENLDSALDLSIKHDLSEVVDALCRRGIALSINKNGESPLWSALEKGYEDVAKILVRHGIDTDC 668
                               .|||.         .:.|.:||..|.:..:|:||::||        
Human   464 -------------------CVDAQ---------EREGWTPLHLAAQNNFENVARLLV-------- 492

  Fly   669 WDEGPEGCRQTLLHRAIDENKESVAIFLIQSQCDLDSSRQPGPNGEGGDEAQDKASPLHLCCHWG 733
                                                 |||..||..   ||:.| :|||:..::|
Human   493 -------------------------------------SRQADPNLH---EAEGK-TPLHVAAYFG 516

  Fly   734 QTKVLQTLIDHGANVNLIDAESKSPLHVAIESQYDEIISILLCHPDIDLKLRDKSGNTPFATALD 798
            ...:::.|...||.::......::|||:|:|......|..||           |||..|  .|||
Human   517 HVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLL-----------KSGAVP--DALD 568

  Fly   799 FRN----HNAAQR-------ILDRFPTAAEQMDIRGRNFLHLAILKDDLESVLFLLAIQVDVNSR 852
            ...    |.||.|       :|.|:..:.|....:|...||||..|..||.:             
Human   569 QSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEII------------- 620

  Fly   853 VHDANQSSPLHLAAASQNEMITRNLILAGARMNERDAVQKLPLHIAIERGNLPAVSALIQNNADY 917
                      ||.|.|.            |.|....||...|||:|...|....||||:|..||.
Human   621 ----------HLLAESH------------ANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADP 663

  Fly   918 DATDADGNNALHIAVRCAQFFIVRELLTESRVNAEATNLKGRNPLHELCRVVEDSTAGLICELFL 982
            :|.:..|...||:||:.:.|..|..|| |...|..|.|..|..|.|                   
Human   664 NAAEQSGWTPLHLAVQRSTFLSVINLL-EHHANVHARNKVGWTPAH------------------- 708

  Fly   983 ESMPKYPINIPDMDGNTPLLLSFMRGQSPLCKILVKAGACLGTENKDGINIFNFKLATDQLLHNL 1047
                                |:.::|.:.:.|:||:|||.|..:  ||::....:||.......:
Human   709 --------------------LAALKGNTAILKVLVEAGAQLDVQ--DGVSCTPLQLALRSRKQGI 751

  Fly  1048 LDQLPQESP 1056
            :..|..:.|
Human   752 MSFLEGKEP 760

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG41099NP_001015359.1 BTB 67..164 CDD:279045
BTB 75..166 CDD:197585
ANK 252..385 CDD:238125 28/166 (17%)
ANK repeat 291..322 CDD:293786 10/30 (33%)
ANK repeat 325..362 CDD:293786 5/46 (11%)
Ank_2 330..431 CDD:289560 23/160 (14%)
ANK 463..595 CDD:238125 27/136 (20%)
ANK repeat 468..501 CDD:293786 7/37 (19%)
Ank_2 473..572 CDD:289560 20/103 (19%)
ANK repeat 503..539 CDD:293786 6/35 (17%)
ANK 536..660 CDD:238125 29/123 (24%)
ANK repeat 541..572 CDD:293786 8/30 (27%)
ANK repeat 574..637 CDD:293786 12/62 (19%)
Ank_2 579..670 CDD:289560 20/90 (22%)
ANK repeat 639..670 CDD:293786 9/30 (30%)
Ank_2 644..752 CDD:289560 22/107 (21%)
ANK repeat 672..721 CDD:293786 7/48 (15%)
ANK 721..843 CDD:238125 38/132 (29%)
ANK repeat 723..752 CDD:293786 7/28 (25%)
ANKYR 752..977 CDD:223738 67/235 (29%)
ANK repeat 754..786 CDD:293786 8/31 (26%)
ANK 820..944 CDD:238125 36/123 (29%)
ANK repeat 822..855 CDD:293786 8/32 (25%)
ANK repeat 857..888 CDD:293786 6/30 (20%)
ANK 885..1017 CDD:238125 34/131 (26%)
ANK repeat 890..921 CDD:293786 14/30 (47%)
ANK repeat 923..955 CDD:293786 12/31 (39%)
ANK repeat 996..1021 CDD:293786 6/24 (25%)
FYVE_ANFY1 1054..1116 CDD:277267 1/3 (33%)
ANKK1XP_011541038.1 STKc_RIP4_like 25..303 CDD:270927 47/266 (18%)
S_TKc 26..291 CDD:214567 43/246 (17%)
ANK repeat 375..403 CDD:293786 6/32 (19%)
Ank_2 377..468 CDD:289560 26/118 (22%)
ANK 400..524 CDD:238125 43/204 (21%)
ANK repeat 405..436 CDD:293786 8/30 (27%)
ANK repeat 438..469 CDD:293786 12/62 (19%)
Ank_2 443..534 CDD:289560 35/171 (20%)
ANK repeat 471..502 CDD:293786 14/78 (18%)
ANK 499..623 CDD:238125 42/163 (26%)
ANK repeat 504..534 CDD:293786 8/30 (27%)
ANK repeat 537..568 CDD:293786 13/43 (30%)
Ank_4 539..591 CDD:290365 19/64 (30%)
ANK 565..690 CDD:238125 46/159 (29%)
ANK repeat 570..601 CDD:293786 7/30 (23%)
Ank_2 575..665 CDD:289560 35/124 (28%)
ANK repeat 603..634 CDD:293786 14/65 (22%)
ANK 638..755 CDD:238125 42/158 (27%)
ANK repeat 638..667 CDD:293786 13/28 (46%)
Ank_2 641..733 CDD:289560 37/133 (28%)
ANK repeat 669..700 CDD:293786 12/31 (39%)
ANK repeat 702..733 CDD:293786 12/71 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0192
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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