DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG41099 and Dstyk

DIOPT Version :9

Sequence 1:	NP_001015359.1	Gene:	CG41099 / 3355072	FlyBaseID:	FBgn0039955	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_766104.2	Gene:	Dstyk / 213452	MGIID:	1925064	Length:	927	Species:	Mus musculus

Alignment Length:	717	Identity:	140/717 - (19%)
Similarity:	238/717 - (33%)	Gaps:	232/717 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 IYTDLIDLQNDGLALDLLKAAHRFGLPS---------LLGICERALVTSVGVRSCIRFYCVAEEV 182
            :|..|:|       |..|.::||..:||         |:...|:....|......::...|....
Mouse   301 LYGQLVD-------LGYLSSSHRNCVPSDQDCKAQSMLVEQSEKLKQLSTFSHQLLQNRLVDAAK 358

  Fly   183 GASTLLEYCSSIISTHWDDLTTD--------DFQHMSGPLLFEMLKTKTKHPLHAAVRLLREDVV 239
            ..:.:..:|..|......|:..|        ::.......|:|.|       ::.|.| .:|::.
Mouse   359 ALNVVHSHCLDIFINQAFDMQRDLQITPKRLEYTRKKENELYESL-------MNIANR-KQEEMK 415

  Fly   240 SLCIQKYGNSLVNTFSENGILPLEMALSSKNAKIAKSLV-DNG--------MANINAVNMEGFSL 295
            .:.::     .:||..|      |:...:.|.:....:| :||        .:.|..:.....|.
Mouse   416 DMIVE-----TLNTMKE------ELLDDAANMEFKDVIVPENGETIGTREIKSCIRQIQELIISR 469

  Fly   296 LKSALKNGDAFSANFLLD------QNCLLDLPSKPSSDTALHIICNYGPDNTPEIMEVVKKILQR 354
            |..|:.|....|.::|.:      :.||..|  :.|.|.::||..||           :|:||..
Mouse   470 LNQAVANKLISSVDYLRESFVGTLERCLQSL--EKSQDVSVHITSNY-----------LKQILNA 521

  Fly   355 QLNINIQNIKGETPLHIAIARRNVEMVKLLLK------VPNIDINLRTYDEKCALEL--SLSMGD 411
            ..::.:....|.     ::.|...|.:|.:::      .|.|.:.   :..|.|.|.  |||...
Mouse   522 AYHVEVTFHSGS-----SVTRMLWEQIKQIIQRITWVNPPTITLE---WKRKVAQEAIDSLSASK 578

  Fly   412 HEFLIASILLSMGARTDRTNSKTGDSLLQVFALDRHRGEKSAIFLADFADL------DHINFRGL 470
               |..||......|.:.::.....||.|:.|....|.||:       .||      ||......
Mouse   579 ---LAKSICSQFRTRLNSSHEAFAASLRQLEAGHSGRLEKT-------EDLWLKVRKDHAPRLAR 633

  Fly   471 TALHIAALNNM-----PNLVKKL------IVNGASSNLKHIDCGLKSAL--------HIAVEANA 516
            .:|...:|.::     |.|.::|      :|....:...|..|.|||.:        .:|:|.:.
Mouse   634 LSLESRSLQDVLLHRKPKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHY 698

  Fly   517 IDAL---EAFVELKNKSHDIDFNCQDINGDSPLSLCL-----------SLKRTTLVPTLIRGGSD 567
            :.:|   |..|:|....  ||:|   ..|.|.:::.|           .||....:.|.::...|
Mouse   699 MRSLPKHERLVDLHGSV--IDYN---YGGGSSVAVLLIMERLHRDLYTGLKAGLTLETRLQIALD 758

  Fly   568 VNGKNKNNLSPLH-QSIKNEDSDISLFLLEQ--GADITAL------------------------- 604
            |    ...:..|| |.:.:.|..:...||::  .|.||.|
Mouse   759 V----VEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELF 819

  Fly   605 TENLDSALDL-------------SIKHDLSEVVDALCRRGIALSINKNGESP---------LWSA 647
            |...|:::|:             |||  |.|..:....:....:..:.|..|         .|..
Mouse   820 TGKYDNSVDVYAFGILFWYICSGSIK--LPEAFERCASKDHLWNNVRRGTRPERLPVFDEECWQL 882

  Fly   648 LEKGYEDVAKILVRHGIDTDCWDEGP-----EGCRQTLLHRAIDENKESVAIFLIQSQCDLDSSR 707
            :|.                 |||..|     .|..|.:|...:|.          ..:|   ||.
Mouse   883 MEA-----------------CWDGDPLKRPLLGIVQPMLRSIMDR----------LCKC---SSE 917

  Fly   708 QP 709
            ||
Mouse   918 QP 919

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG41099	NP_001015359.1	BTB	67..164	CDD:279045	11/45 (24%)
		BTB	75..166	CDD:197585	11/47 (23%)
		ANK	252..385	CDD:238125	31/147 (21%)
		ANK repeat	291..322	CDD:293786	9/36 (25%)
		ANK repeat	325..362	CDD:293786	9/36 (25%)
		Ank_2	330..431	CDD:289560	23/108 (21%)
		ANK	463..595	CDD:238125	34/165 (21%)
		ANK repeat	468..501	CDD:293786	7/43 (16%)
		Ank_2	473..572	CDD:289560	28/131 (21%)
		ANK repeat	503..539	CDD:293786	12/46 (26%)
		ANK	536..660	CDD:238125	31/184 (17%)
		ANK repeat	541..572	CDD:293786	8/41 (20%)
		ANK repeat	574..637	CDD:293786	18/103 (17%)
		Ank_2	579..670	CDD:289560	23/140 (16%)
		ANK repeat	639..670	CDD:293786	5/39 (13%)
		Ank_2	644..752	CDD:289560	15/71 (21%)
		ANK repeat	672..721	CDD:293786	10/43 (23%)
		ANK	721..843	CDD:238125
		ANK repeat	723..752	CDD:293786
		ANKYR	752..977	CDD:223738
		ANK repeat	754..786	CDD:293786
		ANK	820..944	CDD:238125
		ANK repeat	822..855	CDD:293786
		ANK repeat	857..888	CDD:293786
		ANK	885..1017	CDD:238125
		ANK repeat	890..921	CDD:293786
		ANK repeat	923..955	CDD:293786
		ANK repeat	996..1021	CDD:293786
		FYVE_ANFY1	1054..1116	CDD:277267
Dstyk	NP_766104.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		PKc_Dusty	649..910	CDD:270877	55/288 (19%)
		S_TKc	651..895	CDD:214567	51/271 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900