DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG41099 and Ripk1

DIOPT Version :9

Sequence 1:NP_001015359.1 Gene:CG41099 / 3355072 FlyBaseID:FBgn0039955 Length:1124 Species:Drosophila melanogaster
Sequence 2:NP_001346926.1 Gene:Ripk1 / 19766 MGIID:108212 Length:656 Species:Mus musculus


Alignment Length:306 Identity:54/306 - (17%)
Similarity:99/306 - (32%) Gaps:117/306 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   104 LSNIQQLDWSDLNEDVVLS------------------LLRWIYTDLIDLQNDGLALDLLKAAHRF 150
            |.||:... |||.|...|.                  :|:.:||.....:.:.:.|:..|..||.
Mouse     7 LDNIKMAS-SDLLEKTDLDSGGFGKVSLCYHRSHGFVILKKVYTGPNRAEYNEVLLEEGKMMHRL 70

  Fly   151 ---GLPSLLGICERALVTSVGVRSCIRFYCVAEEVGASTLLEYCSSIISTHWDDLTTDDFQHMSG 212
               .:..||||                   :.||...|.::||                   |..
Mouse    71 RHSRVVKLLGI-------------------IIEEGNYSLVMEY-------------------MEK 97

  Fly   213 PLLFEMLKTKTKHPLHAAVRLLREDVVSLCIQKYGNSLVNTFSENGILPLEMALSSKNAKIAKSL 277
            ..|..:|||:...||....|::.|.:..:|.          ..:.|::       .|:.|....|
Mouse    98 GNLMHVLKTQIDVPLSLKGRIIVEAIEGMCY----------LHDKGVI-------HKDLKPENIL 145

  Fly   278 VDNG----MANINAVNMEGFSLL-----------KSALKNGDAFSANFLLDQNCLLDLPSKPSSD 327
            ||..    :|::...:.:.:|.|           .|..|..:..:..::..:: |.|:.:||:..
Mouse   146 VDRDFHIKIADLGVASFKTWSKLTKEKDNKQKEVSSTTKKNNGGTLYYMAPEH-LNDINAKPTEK 209

  Fly   328 TALH------------------IICN------YGPDNTPEIMEVVK 349
            :.::                  :||.      ....|.|.:.|:::
Mouse   210 SDVYSFGIVLWAIFAKKEPYENVICTEQFVICIKSGNRPNVEEILE 255

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG41099NP_001015359.1 BTB 67..164 CDD:279045 19/80 (24%)
BTB 75..166 CDD:197585 19/82 (23%)
ANK 252..385 CDD:238125 20/137 (15%)
ANK repeat 291..322 CDD:293786 6/41 (15%)
ANK repeat 325..362 CDD:293786 5/49 (10%)
Ank_2 330..431 CDD:289560 5/44 (11%)
ANK 463..595 CDD:238125
ANK repeat 468..501 CDD:293786
Ank_2 473..572 CDD:289560
ANK repeat 503..539 CDD:293786
ANK 536..660 CDD:238125
ANK repeat 541..572 CDD:293786
ANK repeat 574..637 CDD:293786
Ank_2 579..670 CDD:289560
ANK repeat 639..670 CDD:293786
Ank_2 644..752 CDD:289560
ANK repeat 672..721 CDD:293786
ANK 721..843 CDD:238125
ANK repeat 723..752 CDD:293786
ANKYR 752..977 CDD:223738
ANK repeat 754..786 CDD:293786
ANK 820..944 CDD:238125
ANK repeat 822..855 CDD:293786
ANK repeat 857..888 CDD:293786
ANK 885..1017 CDD:238125
ANK repeat 890..921 CDD:293786
ANK repeat 923..955 CDD:293786
ANK repeat 996..1021 CDD:293786
FYVE_ANFY1 1054..1116 CDD:277267
Ripk1NP_001346926.1 PKc_like 23..291 CDD:419665 47/289 (16%)
Interaction with SQSTM1. /evidence=ECO:0000250|UniProtKB:Q13546 291..567
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 327..373
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 388..423
RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269|PubMed:18442983, ECO:0000269|PubMed:27819681, ECO:0000269|PubMed:27819682 520..536
Death_RIP1 568..653 CDD:260048
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0192
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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