DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG41099 and Ank1

DIOPT Version :9

Sequence 1:	NP_001015359.1	Gene:	CG41099 / 3355072	FlyBaseID:	FBgn0039955	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	XP_006509052.1	Gene:	Ank1 / 11733	MGIID:	88024	Length:	1950	Species:	Mus musculus

Alignment Length:	1005	Identity:	246/1005 - (24%)
Similarity:	401/1005 - (39%)	Gaps:	194/1005 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 AHRFGLPS-LLGICERALVTSVGVRSCIRFYCVAEEVGASTLLEYCSSIISTHWDDLTTDDFQHM 210
            |.|..:|| .:|.|:....||        |...|........|::..:.:     |:.|.:...:
Mouse    46 AGRVLVPSNKMGFCKADAATS--------FLRAARSGNLDKALDHLRNGV-----DINTCNQNGL 97

  Fly   211 SG--------------PLLFE--MLKTKTKH---PLHAAVRLLREDVVSLCIQKYGNSLVNTFSE 256
            :|              .||.:  :|:|.||.   .||.|....:::||...: .||.: ||..|:
Mouse    98 NGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELV-NYGAN-VNAQSQ 160

  Fly   257 NGILPLEMALSSKNAKIAKSLVDNGMANINAVNMEGFSLLKSAL--------------------- 300
            .|..||.||....:.::.|.|::|| ||.|....:||:.|..||
Mouse   161 KGFTPLYMAAQENHLEVVKFLLENG-ANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR 224

  Fly   301 --------KNGDAFSANFLLDQNCLLDLPSKPSSDTALHIICNYGPDNTPEIMEVVKKILQRQLN 357
                    :|.|..:|..||..:...|:.|| :..|.|||..:|      |.:.|.:.:|.|..:
Mouse   225 LPALHIAARNDDTRTAAVLLQNDPNPDVLSK-TGFTPLHIAAHY------ENLNVAQLLLNRGAS 282

  Fly   358 INIQNIKGETPLHIAIARRNVEMVKLLLKVPNIDINLRTYDEKCALELSLSMGDHEFLIASILLS 422
            :|.....|.||||||..|.||.||:|||. ....|..||.||...|..:...|  ...|:.|||.
Mouse   283 VNFTPQNGITPLHIASRRGNVIMVRLLLD-RGAQIETRTKDELTPLHCAARNG--HVRISEILLD 344

  Fly   423 MGARTDRTNSKTGDSLLQVFALDRHRGEKSAIFLADFADLDHINFRGLTALHIAALNNMPNLVKK 487
            .||.. :..:|.|.|.:.:.|...|. :...:.|...|::|.|....||.||:||......:.|.
Mouse   345 HGAPI-QAKTKNGLSPIHMAAQGDHL-DCVRLLLQYNAEIDDITLDHLTPLHVAAHCGHHRVAKV 407

  Fly   488 LIVNGASSNLKHIDCGLKSALHIAVEANAIDALEAFVELKNKSHDIDFNCQDINGDSPLSLCLSL 552
            |:..||..|.:.:: |. :.||||.:.|.|..:|.   |......||...:  :|.:||.:...:
Mouse   408 LLDKGAKPNSRALN-GF-TPLHIACKKNHIRVMEL---LLKTGASIDAVTE--SGLTPLHVASFM 465

  Fly   553 KRTTLVPTLIRGGSDVNGKNKNNLSPLHQSIKNEDSDISLFLLEQGADITALTENLDSALDLSIK 617
            ....:|..|::.|:..|..|....:|||.:.:...::::.:||:..|...|..
Mouse   466 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKANAKA------------ 518

  Fly   618 HDLSEVVDALCRRGIALSINKNGESPLWSALEKGYEDVAKILVRHGIDTDCWDEGPEGCRQTLLH 682
                                |:.::||..|...|:..:.|:|:.:|...:.    ......|.||
Mouse   519 --------------------KDDQTPLHCAARIGHTGMVKLLLENGASPNL----ATTAGHTPLH 559

  Fly   683 RAIDENKESVAIFLIQSQCDLDSSRQPGPNGEGGDEAQDKASPLHLCCHWGQTKVLQTLIDHGAN 747
            .|..|.....|:.|::.:.......:.|            .:|||:...:|:.::.:.|::|.|:
Mouse   560 TAAREGHVDTALALLEKEASQACMTKKG------------FTPLHVAAKYGKVRLAELLLEHDAH 612

  Fly   748 VNLIDAESKSPLHVAIESQYDEIISILLCHPDIDLKLRDKSGNTPFATALDFRN--HNAAQ---- 806
            .|.......:|||||:.....:|:.:||           ..|.:|.:.|.:...  |.||:
Mouse   613 PNAAGKNGLTPLHVAVHHNNLDIVKLLL-----------PRGGSPHSPAWNGYTPLHIAAKQNQI 666

  Fly   807 ---RILDRFPTAAEQMDIRGRNFLHLAILKDDLESVLFLLAIQVDVNSRVHDANQSSPLHLAAAS 868
               |.|.::..:|....::|...||||..:...|.|..||:.|  .|..:.:.:..:||||.:..
Mouse   667 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHTEMVALLLSKQ--ANGNLGNKSGLTPLHLVSQE 729

  Fly   869 QNEMITRNLILAGARMNERDAVQKLPLHIAIERGNLPAVSALIQNNADYDATDADGNNALHIAVR 933
            .:..:...||..|..::....:...|||:|...||:..|..|:|:.||.:|....|.:.||.|.:
Mouse   730 GHVPVADVLIKHGVTVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQ 794

  Fly   934 CAQFFIVRELLTESRVNAEATNLKGRNPL-----------HELCRVVEDSTA-GLICELFLESMP 986
            .....|| .||.::..:....:..|..||           .::.:||.|.|: .|:.:....|.|
Mouse   795 QGHTDIV-TLLLKNGASPNEVSSNGTTPLAIAKRLGYISVTDVLKVVTDETSVVLVSDKHRMSYP 858

  Fly   987 KYPINIPDM--DGNTPLLLSFMRGQSPLCKILVKAGACLGT--ENKDGINIFNFKLATDQLLHNL 1047
            :....|.|:  |..|             ..|.:.....:|:  |.:|..::...|        .|
Mouse   859 ETVDEILDVSEDEGT-------------AHISIMGDELVGSKAERRDSRDVGEEK--------EL 902

  Fly  1048 LDQLPQESPWAESDYCQH--CTNRFTITMR 1075
            ||.:|:.....||.....  |....|:.:|
Mouse   903 LDFVPKLDQVVESPAIPRIPCVTPETVVIR 932

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG41099	NP_001015359.1	BTB	67..164	CDD:279045	6/17 (35%)
		BTB	75..166	CDD:197585	6/19 (32%)
		ANK	252..385	CDD:238125	50/161 (31%)
		ANK repeat	291..322	CDD:293786	11/59 (19%)
		ANK repeat	325..362	CDD:293786	10/36 (28%)
		Ank_2	330..431	CDD:289560	37/100 (37%)
		ANK	463..595	CDD:238125	35/131 (27%)
		ANK repeat	468..501	CDD:293786	11/32 (34%)
		Ank_2	473..572	CDD:289560	27/98 (28%)
		ANK repeat	503..539	CDD:293786	11/35 (31%)
		ANK	536..660	CDD:238125	21/123 (17%)
		ANK repeat	541..572	CDD:293786	7/30 (23%)
		ANK repeat	574..637	CDD:293786	7/62 (11%)
		Ank_2	579..670	CDD:289560	14/90 (16%)
		ANK repeat	639..670	CDD:293786	7/30 (23%)
		Ank_2	644..752	CDD:289560	22/107 (21%)
		ANK repeat	672..721	CDD:293786	8/48 (17%)
		ANK	721..843	CDD:238125	32/130 (25%)
		ANK repeat	723..752	CDD:293786	8/28 (29%)
		ANKYR	752..977	CDD:223738	62/245 (25%)
		ANK repeat	754..786	CDD:293786	8/31 (26%)
		ANK	820..944	CDD:238125	36/123 (29%)
		ANK repeat	822..855	CDD:293786	11/32 (34%)
		ANK repeat	857..888	CDD:293786	7/30 (23%)
		ANK	885..1017	CDD:238125	35/145 (24%)
		ANK repeat	890..921	CDD:293786	12/30 (40%)
		ANK repeat	923..955	CDD:293786	8/31 (26%)
		ANK repeat	996..1021	CDD:293786	3/24 (13%)
		FYVE_ANFY1	1054..1116	CDD:277267	5/24 (21%)
Ank1	XP_006509052.1	ANK repeat	454..485	CDD:293786	7/30 (23%)
		ANK repeat	487..518	CDD:293786	7/30 (23%)
		ANK repeat	520..549	CDD:293786	7/28 (25%)
		ANK repeat	554..584	CDD:293786	7/29 (24%)
		ANK repeat	586..617	CDD:293786	9/42 (21%)
		Ank_2	597..>810	CDD:393464	60/226 (27%)
		ANK repeat	619..647	CDD:293786	9/38 (24%)
		ANK repeat	652..682	CDD:293786	6/29 (21%)
		ANK repeat	685..716	CDD:293786	11/32 (34%)
		ANK repeat	718..749	CDD:293786	7/30 (23%)
		ANK repeat	751..782	CDD:293786	12/30 (40%)
		ANK repeat	784..812	CDD:293786	8/28 (29%)
		Ank_4	785..837	CDD:372654	11/52 (21%)
		ZU5	970..1074	CDD:128514
		UPA_2	1295..1424	CDD:375346
		Death_ank1	1460..1543	CDD:260067
		ANK repeat	65..93	CDD:293786	7/40 (18%)
		Ank_2	67..158	CDD:372319	21/97 (22%)
		ANK repeat	95..126	CDD:293786	5/30 (17%)
		ANK repeat	129..159	CDD:293786	9/31 (29%)
		PHA02876	<141..>486	CDD:165207	108/366 (30%)
		ANK repeat	161..192	CDD:293786	12/31 (39%)
		ANK repeat	194..218	CDD:293786	5/23 (22%)
		ANK repeat	227..254	CDD:293786	6/26 (23%)
		ANK repeat	257..287	CDD:293786	10/35 (29%)
		ANK repeat	289..320	CDD:293786	16/31 (52%)
		ANK repeat	322..353	CDD:293786	10/33 (30%)
		ANK repeat	355..386	CDD:293786	7/31 (23%)
		ANK repeat	391..419	CDD:293786	10/27 (37%)
		ANK repeat	421..452	CDD:293786	11/35 (31%)
		PHA02875	433..>643	CDD:165206	53/273 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	1	0.960