DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG41099 and Ankhd1

DIOPT Version :9

Sequence 1:	NP_001015359.1	Gene:	CG41099 / 3355072	FlyBaseID:	FBgn0039955	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_780584.2	Gene:	Ankhd1 / 108857	MGIID:	1921733	Length:	2548	Species:	Mus musculus

Alignment Length:	1066	Identity:	224/1066 - (21%)
Similarity:	374/1066 - (35%)	Gaps:	316/1066 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 DVVSLCIQKYGNSLVNTFSENGILPLEMALSSKNAKIAKSLVDNGMANINA-------------- 287
            |:|.:.:.:..|  :...:|||..||..|.|:.:.::|:.|:|:| |.||.
Mouse   322 DIVKVLLNEGAN--IEDHNENGHTPLMEAASAGHVEVARVLLDHG-AGINTHSNEFKESALTLAC 383

  Fly   288 ----VNMEGFSL----------------LKSALKNGDAFSANFLLDQNCLLDLPSKPSSDTALHI 332
                ::|..|.|                |..|..:|....|..|||....:::|: .|.::.|.:
Mouse   384 YKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPA-DSFESPLTL 447

  Fly   333 ICNYGPDNTPEIMEVVKKILQRQLNINIQNIKGETPLHIAIARRNVEMVKLLLKVPNIDINLRTY 397
            ....|.      :|:...:::|..|:...|.:|.|||..|....:.|||.||| ....:||.:|.
Mouse   448 AACGGH------VELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLL-AQGANINAQTE 505

  Fly   398 D-EKCALELSLSMGDHEFLIASILLSMGARTDRTNSKTGDSLLQVFALDRHRGEKSAIFLADFAD 461
            : ::.||.|:...|..|  :|..|:..||     :.:.|.|...:.|......|.....||..|:
Mouse   506 ETQETALTLACCGGFSE--VADFLIKAGA-----DIELGCSTPLMEASQEGHLELVKYLLAAGAN 563

  Fly   462 LDHINFRGLTALHIAALNNMPNLVKKLIVNGASSNLKHIDCGLKSALHIAVEANAIDALEAFVEL 526
            :......|.|||..|..|...::...|:..||  :|:|...|.::.|..|..|..:..::..:
Mouse   564 VHATTATGDTALTYACENGHTDVADVLLQAGA--HLEHESEGGRTPLMKAARAGHLCTVQFLI-- 624

  Fly   527 KNKSHDIDFNCQDINGD-SPLSLCLSLKRTTLVPTLIRGGSDVNGKNKNNLSPLHQSIKNEDSDI 590
               |...:.|....|.| :.:||..:.....:|..|:..|:|...:.|:..:.|.::.|...:::
Mouse   625 ---SKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNV 686

  Fly   591 SLFLLE--------QGADITALT--ENLDSALDLSIKHDLSEVV-----------DALCRRGIAL 634
            ..:||:        ...|::.||  ...:|.:.....|.|:.||           .:....|:..
Mouse   687 VSYLLDYPNNVLSVPTTDVSQLTSPSQDESQVPRVPIHTLAMVVPPQEPDRTSQETSTALLGVQK 751

  Fly   635 SINKNGESPLW----------------------------------SALEKGYEDVAKILVRHGID 665
            ..:|...|.|.                                  ||:||......:::....::
Mouse   752 GASKQKSSSLQVADQDLLPPFHPYQPLECIVEETEGKLNELGQRISAIEKAQLKSLELIQGEPLN 816

  Fly   666 TDCWDE---------------------------------------------GPEGCRQTLLHRAI 685
            .|..:|                                             ..|...|...:|.:
Mouse   817 KDKIEELKKNREEQVQKKKKILKELQKVERQLQMKTQQQFTKEYLETKGQRDTESPHQQCSNRGV 881

  Fly   686 ------------DENKESVAI-FLIQSQCDLDSSRQPGPNGEGGD--EAQDKASPLHLCCHW--- 732
                        |.:.||..: .::....|:|..:|..|:.|..|  ..|..:||.   |::
Mouse   882 FMAGEEDGSLPQDHSSESPQLDTVLFKDHDIDDKQQSPPSAEQIDFVPVQPLSSPQ---CNFFSD 943

  Fly   733 ---------------------GQTKV----------------------LQTLIDH---------- 744
                                 ||.::                      .|||.|.
Mouse   944 LGSNGTNSLVLQKVSGNQQIVGQPQIAIAGHEQGLLVQEPDGLMVATPAQTLTDTLDDLIAAVST 1008

  Fly   745 ----GAN------------------VNL-------------IDAESKS----PLHVAIESQYDEI 770
                |:|                  .|:             |||.::|    .|.:|....::|:
Mouse  1009 RVPVGSNNPSQTTECPTPESCYQTPSNMATPSTPPVYPSVDIDAHTESNHDTALTLACAGGHEEL 1073

  Fly   771 ISILLCHPDIDLKLRDKSGNTPFATALDFRNHNAAQRILDRFPTAAEQMDIRGRNFLHLAILKDD 835
            :|:|:.. |..::.|||.|.||...|....:....:.:||:......|.:......|.||.....
Mouse  1074 VSVLIAR-DAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGR 1137

  Fly   836 LESVLFLLAIQVDVNSRVHDANQSSPLHLAAASQNEMITRNLILAGARMNERDAVQKL---PLHI 897
            .|.|..|||  ...|....:.:..:||.|||:.....|.:.|:.|||.:|.|.. .||   ||.:
Mouse  1138 QEVVDLLLA--RGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTG-SKLGISPLML 1199

  Fly   898 AIERGNLPAVSALIQNNADYDA-TDADGNNALHIAVRCAQFFIVRELLTESRVNAEATNLKGRNP 961
            |...|::|||..|:...:|.:| .:.:.|.||.:|....:..:| .||.:.:.|.|.....|..|
Mouse  1200 AAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVV-SLLLDRKANVEHRAKTGLTP 1263

  Fly   962 LHELC--------RVVEDSTAGL-----------------------ICELFLESMPKYPINIPDM 995
            |.|..        ||:.|..|.:                       .|||.:.....  |::.:.
Mouse  1264 LMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLINRGAH--IDVRNK 1326

  Fly   996 DGNTPLLLSFMRGQSPLCKILVKAGA 1021
            .|||||.|:...|...:.::||:|||
Mouse  1327 KGNTPLWLASNGGHFDVVQLLVQAGA 1352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG41099	NP_001015359.1	BTB	67..164	CDD:279045
		BTB	75..166	CDD:197585
		ANK	252..385	CDD:238125	41/166 (25%)
		ANK repeat	291..322	CDD:293786	9/46 (20%)
		ANK repeat	325..362	CDD:293786	6/36 (17%)
		Ank_2	330..431	CDD:289560	29/101 (29%)
		ANK	463..595	CDD:238125	28/132 (21%)
		ANK repeat	468..501	CDD:293786	11/32 (34%)
		Ank_2	473..572	CDD:289560	22/99 (22%)
		ANK repeat	503..539	CDD:293786	6/35 (17%)
		ANK	536..660	CDD:238125	30/179 (17%)
		ANK repeat	541..572	CDD:293786	8/31 (26%)
		ANK repeat	574..637	CDD:293786	13/83 (16%)
		Ank_2	579..670	CDD:289560	21/145 (14%)
		ANK repeat	639..670	CDD:293786	7/64 (11%)
		Ank_2	644..752	CDD:289560	32/292 (11%)
		ANK repeat	672..721	CDD:293786	12/63 (19%)
		ANK	721..843	CDD:238125	37/216 (17%)
		ANK repeat	723..752	CDD:293786	12/119 (10%)
		ANKYR	752..977	CDD:223738	69/263 (26%)
		ANK repeat	754..786	CDD:293786	7/35 (20%)
		ANK	820..944	CDD:238125	38/127 (30%)
		ANK repeat	822..855	CDD:293786	9/32 (28%)
		ANK repeat	857..888	CDD:293786	11/30 (37%)
		ANK	885..1017	CDD:238125	42/166 (25%)
		ANK repeat	890..921	CDD:293786	12/34 (35%)
		ANK repeat	923..955	CDD:293786	9/31 (29%)
		ANK repeat	996..1021	CDD:293786	10/24 (42%)
		FYVE_ANFY1	1054..1116	CDD:277267
Ankhd1	NP_780584.2	Ank_2	212..304	CDD:289560
		ANK repeat	212..238	CDD:293786
		ANK	235..361	CDD:238125	11/40 (28%)
		ANK repeat	240..272	CDD:293786
		ANK repeat	277..305	CDD:293786
		Ank_2	279..368	CDD:289560	15/48 (31%)
		ANK	302..428	CDD:238125	24/108 (22%)
		ANK repeat	307..338	CDD:293786	3/17 (18%)
		ANK repeat	340..372	CDD:293786	13/32 (41%)
		ANK	370..494	CDD:238125	27/130 (21%)
		ANK repeat	374..405	CDD:293786	3/30 (10%)
		Ank_4	377..428	CDD:290365	7/50 (14%)
		ANK repeat	409..438	CDD:293786	7/28 (25%)
		Ank_2	412..503	CDD:289560	28/98 (29%)
		ANK repeat	440..471	CDD:293786	6/36 (17%)
		ANK repeat	473..503	CDD:293786	13/30 (43%)
		ANK repeat	506..535	CDD:293786	9/35 (26%)
		ANK	540..658	CDD:238125	27/124 (22%)
		ANK repeat	540..568	CDD:293786	5/27 (19%)
		Ank_2	542..632	CDD:289560	21/96 (22%)
		ANK repeat	570..601	CDD:293786	11/32 (34%)
		ANK repeat	603..632	CDD:293786	5/33 (15%)
		Ank_2	608..697	CDD:289560	18/93 (19%)
		ANK	633..>697	CDD:238125	13/63 (21%)
		ANK repeat	637..667	CDD:293786	7/29 (24%)
		MAP7	<783..>870	CDD:283355	6/86 (7%)
		Prefoldin	<817..855	CDD:298833	2/37 (5%)
		ANK repeat	1059..1088	CDD:293786	6/29 (21%)
		Ank_2	1062..1155	CDD:289560	25/95 (26%)
		ANK	1086..1213	CDD:238125	40/129 (31%)
		ANK repeat	1090..1122	CDD:293786	7/31 (23%)
		ANK repeat	1124..1155	CDD:293786	9/32 (28%)
		Ank_2	1129..1222	CDD:289560	32/95 (34%)
		ANK repeat	1157..1188	CDD:293786	11/30 (37%)
		ANK repeat	1192..1222	CDD:293786	10/29 (34%)
		Ank_2	1197..1288	CDD:289560	26/91 (29%)
		ANK repeat	1225..1257	CDD:293786	9/32 (28%)
		ANK	1255..1381	CDD:238125	24/100 (24%)
		ANK repeat	1259..1288	CDD:293786	8/28 (29%)
		Ank_2	1264..1358	CDD:289560	22/91 (24%)
		ANK repeat	1294..1325	CDD:293786	4/32 (13%)
		ANK repeat	1327..1358	CDD:293786	12/26 (46%)
		KH-I	1696..1758	CDD:238053
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1115202at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010