DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG41099 and si:cabz01054396.2

DIOPT Version :9

Sequence 1:	NP_001015359.1	Gene:	CG41099 / 3355072	FlyBaseID:	FBgn0039955	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	XP_017210893.2	Gene:	si:cabz01054396.2 / 100537687	ZFINID:	ZDB-GENE-161017-46	Length:	568	Species:	Danio rerio

Alignment Length:	489	Identity:	86/489 - (17%)
Similarity:	143/489 - (29%)	Gaps:	208/489 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   686 DENKESVAIFLIQSQC-DLDSSRQPGPNGE--GGDE-----------AQDKASPLHLCCHWGQTK 736
            ::.:|.:.:.|::.:. |.:.:.||..:.|  .||:           :|:|......|.|.|:..
Zfish    20 EDPEEQIDLILLKEESNDSEEATQPEKHPEFIPGDKSSRSSQTEKPSSQNKTESSLACKHCGEAF 84

  Fly   737 VLQTLIDHGANVNLIDAESKSPLHVAIESQYDEIISILLCHPDIDLKLRDKSGNTPFATALDFRN 801
            ..::                                      .:||.::...|..|:|.|
Zfish    85 TRKS--------------------------------------SLDLHMKAHMGEKPYACA----- 106

  Fly   802 HNAAQRILDRFPTAAEQMDIRGRNFLHLAILKDDLESVLFLLAIQVDVNSRVHDANQSSPLHLAA 866
                               ..|::|.|...||..:.
Zfish   107 -------------------ECGKSFTHKGYLKTHMR----------------------------- 123

  Fly   867 ASQNEMITRNLILAGARMNERDAVQKLPLHIAIERGNLPAVSALIQNNADYDATDADGNNALHIA 931
             |.||..:.:..|..:..:.:.:   |..|:.:..|..|                       :..
Zfish   124 -SHNEESSYSCALCDSSFSRKGS---LKTHMRVHTGEKP-----------------------YTC 161

  Fly   932 VRCAQFFIVRELLTESRVNAEATNLKGRNPLHELCRVVEDS---TAGLICELFLESMPKYPINIP 993
            .:|.:.|     ..:..:|....:..|.|  |.:|::..:|   ...|...:.:.:..| |...|
Zfish   162 AQCGKSF-----TRKGTLNTHMRSHSGEN--HHICKLCGNSFSRKGSLKAHMRIHTGEK-PYECP 218

  Fly   994 DMD-----------------GNTP---LLLSFMRGQSPLCKILVKAGACL----GTENKDGINIF 1034
            ...                 |.||   :..||.|.|.|..|...|..||:    |.:.|..:|
Zfish   219 QCQRSFTRKGTLNSHLKTHIGVTPSSKIKKSFFRRQHPKTKTEEKPFACVQCARGFKYKKNLN-- 281

  Fly  1035 NFKLATDQLLHNLLDQLPQESPWAESDYCQHCTNRFT--ITMRKH---H-------CRHCGRVLC 1087
                 ....:|:      :||.:.    ||||..|||  |.:|.|   |       |.|||:...
Zfish   282 -----QHMRIHS------RESCFV----CQHCGRRFTSRIYLRNHLKTHTGEKPYVCTHCGKSFS 331

  Fly  1088 SKCSCNDVPILKFGINKPVRVCT--VCFNVLQCG 1119
                      ||..|...:|:.|  ..|...|||
Zfish   332 ----------LKGSIKVHMRIHTGEKPFTCEQCG 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG41099	NP_001015359.1	BTB	67..164	CDD:279045
		BTB	75..166	CDD:197585
		ANK	252..385	CDD:238125
		ANK repeat	291..322	CDD:293786
		ANK repeat	325..362	CDD:293786
		Ank_2	330..431	CDD:289560
		ANK	463..595	CDD:238125
		ANK repeat	468..501	CDD:293786
		Ank_2	473..572	CDD:289560
		ANK repeat	503..539	CDD:293786
		ANK	536..660	CDD:238125
		ANK repeat	541..572	CDD:293786
		ANK repeat	574..637	CDD:293786
		Ank_2	579..670	CDD:289560
		ANK repeat	639..670	CDD:293786
		Ank_2	644..752	CDD:289560	13/79 (16%)
		ANK repeat	672..721	CDD:293786	8/48 (17%)
		ANK	721..843	CDD:238125	15/121 (12%)
		ANK repeat	723..752	CDD:293786	3/28 (11%)
		ANKYR	752..977	CDD:223738	27/227 (12%)
		ANK repeat	754..786	CDD:293786	2/31 (6%)
		ANK	820..944	CDD:238125	15/123 (12%)
		ANK repeat	822..855	CDD:293786	5/32 (16%)
		ANK repeat	857..888	CDD:293786	4/30 (13%)
		ANK	885..1017	CDD:238125	25/154 (16%)
		ANK repeat	890..921	CDD:293786	4/30 (13%)
		ANK repeat	923..955	CDD:293786	3/31 (10%)
		ANK repeat	996..1021	CDD:293786	10/44 (23%)
		FYVE_ANFY1	1054..1116	CDD:277267	23/75 (31%)
si:cabz01054396.2	XP_017210893.2	C2H2 Zn finger	77..97	CDD:275370	5/57 (9%)
		COG5048	101..510	CDD:227381	70/370 (19%)
		C2H2 Zn finger	105..125	CDD:275368	6/73 (8%)
		C2H2 Zn finger	133..153	CDD:275368	3/22 (14%)
		C2H2 Zn finger	161..181	CDD:275368	3/24 (13%)
		C2H2 Zn finger	189..209	CDD:275368	3/19 (16%)
		C2H2 Zn finger	217..237	CDD:275368	1/19 (5%)
		C2H2 Zn finger	267..287	CDD:275368	4/26 (15%)
		C2H2 Zn finger	295..315	CDD:275368	10/19 (53%)
		C2H2 Zn finger	323..343	CDD:275368	8/29 (28%)
		C2H2 Zn finger	351..371	CDD:275368	3/5 (60%)
		C2H2 Zn finger	379..399	CDD:275368
		C2H2 Zn finger	407..427	CDD:275368
		C2H2 Zn finger	435..455	CDD:275368
		C2H2 Zn finger	463..483	CDD:275368
		C2H2 Zn finger	492..512	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1115202at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010