DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG41099 and LOC100490559

DIOPT Version :9

Sequence 1:	NP_001015359.1	Gene:	CG41099 / 3355072	FlyBaseID:	FBgn0039955	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	XP_031750905.1	Gene:	LOC100490559 / 100490559	-ID:	-	Length:	764	Species:	Xenopus tropicalis

Alignment Length:	840	Identity:	162/840 - (19%)
Similarity:	265/840 - (31%)	Gaps:	243/840 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 AHKIVLHARSEKWGNDLLSNIQQLDWSDLNEDVVLSLLRWIYTDLIDLQNDGLALDLLKAAHRFG 151
            ||......||:|..:..:...||:..|:...:|.|.:: ::.|....:.:...:..:|::.   |
Frog    34 AHPAGRMKRSKKGSDTGMGGKQQIPLSERILNVTLEIV-YVLTGEDYVVSKRTSAGILQSC---G 94

  Fly   152 LPSLLGICERALVT-SVGVRSCIR--------------FYCVAEEVGASTLLEYCSSIISTHWDD 201
            ...:.|.|:|.:.| |...||.::              |:.:.||| |....|..|...|..||
Frog    95 DCMMGGFCQRHVPTVSHSSRSALQRENARKVLELISNIFHMLTEEV-AIRHEEAGSYFSSEEWD- 157

  Fly   202 LTTDDFQHMSGPLLF--EMLKTKTKHPLH---------AAVRLLREDVV----------SLCIQK 245
                   ::.|..:|  |::|...:..|.         :::|...|..|          |.|.::
Frog   158 -------YLKGNHVFYTEVIKENPQQQLRSQDDGKEEASSIRSYMEAKVISNNKAPKRCSPCPRE 215

  Fly   246 YGNSLVNTF---------------SENGILPLE-MALSSKN--AKIAKSLVDNGMANINAV-NME 291
            .||.:.|:.               ||:.|.||. ..|.:.:  .....||.|..|.|.... :.|
Frog   216 EGNPMDNSAAPISNYPTASWEGERSESSIDPLTGRTLGTMHIWGHSQSSLNDTSMGNKETCPSWE 280

  Fly   292 GFSLLKSALKN-------------GDAFSANFLLDQNCLLD---------LP---SKPSSDTALH 331
            |....||.:..             |......|:.:::...|         ||   |:|.:.| ||
Frog   281 GGGRAKSPIGPHTDPIQGTSSPVLGSKLRNRFVKEESASWDKEGCSSYSALPEPVSEPGTPT-LH 344

  Fly   332 I-IC-------------------NYGPDNTPEIMEVVKKILQRQLNINI---QNIKGETPLHIA- 372
            : :|                   :|....|||.::............:.   ..||.||....|
Frog   345 MSLCAASSGIKEEYSPWEEGESVDYSCTLTPEAVQTAHTPAPGGPTFHYSRSSGIKEETASRQAG 409

  Fly   373 -IARRNVEMVKLLLKVPNIDI-NLRTYDEKCALELSLSMGDHEFLIASILLSMGARTDRTNSKTG 435
             .:...:...|.|::||:... .:|..::...:..|     |...:.|  .|.|.|....||.|
Frog   410 ESSEFGINPPKELIRVPDPPTPTIRPTNQSPTIYKS-----HVIKVES--ASWGERPLDYNSST- 466

  Fly   436 DSLLQVFALDRHRGEKSAIFLADFADLDHINFRGLTALHIAALNNMPNLVKKLIVNGASSNLKHI 500
                            ..|..||            |:.||.          :..:|...|:::..
Frog   467 ----------------DPIEAAD------------TSAHIT----------RYPLNNRLSDMEFS 493

  Fly   501 DCGLKSALHIAVEANAIDALEAFVELKNKSHDIDFNCQDINGDSPLSLCLS-----LKRTTLV-- 558
            ||..: ...:.:.|.|:.|:.::.|....||......:.......|..||.     .:.|||:
Frog   494 DCAAE-LTRVQLSAPAVAAMYSYAEQPYPSHAGPARHRRTPKGKKLFTCLECGKCFTRNTTLLSH 557

  Fly   559 PTLIRGGSDVNGKNKNNLSPLHQSIKNEDSDISLFLLEQGADITALTENLDSALDLSIKHDLSEV 623
            ....|.|..:.........|.:.|:      :|...:..|....|.:|
Frog   558 QRSHREGMRLTCAECGLCFPRYSSL------VSHQQIHTGGKAFACSE----------------- 599

  Fly   624 VDALCRRGIALSINKN----GESPL-WSALEKGYEDVAKILVRH-GIDTDCWDEGPEGC------ 676
             ..||....:..:|..    ||.|. .|...||:...:. |||| .:.|   .|.|..|
Frog   600 -CGLCFARYSSLLNHQKVHPGEKPFACSECGKGFSRNSN-LVRHKRMHT---GEKPYSCPECGKC 659

  Fly   677 --RQTLLHRAIDENKESVAIFLIQSQCDLDSSRQPGPNGEGGDEAQDKASPLHLCCHWGQTKVLQ 739
              |...|.:.:  ...::......|||.|..:|...........|..:..|...|
Frog   660 FTRNAALIKHL--TAHALGKLFACSQCGLCFTRSATLLSHQKSHAGGQPYPCPQC---------- 712

  Fly   740 TLIDHGANVNLIDAESKSPLHVAIESQYDEIISILLC------HPDIDLKLRDKSGNTPF 793
                |....|:.|.|....:|..     ::|.|...|      |.|....|:..:|:..|
Frog   713 ----HKVFTNVTDLERHQEIHSG-----EKIFSCFECGQHFTHHLDFTEHLQSHTGDDAF 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG41099	NP_001015359.1	BTB	67..164	CDD:279045	16/76 (21%)
		BTB	75..166	CDD:197585	17/79 (22%)
		ANK	252..385	CDD:238125	37/201 (18%)
		ANK repeat	291..322	CDD:293786	9/55 (16%)
		ANK repeat	325..362	CDD:293786	8/59 (14%)
		Ank_2	330..431	CDD:289560	23/126 (18%)
		ANK	463..595	CDD:238125	24/138 (17%)
		ANK repeat	468..501	CDD:293786	5/32 (16%)
		Ank_2	473..572	CDD:289560	20/105 (19%)
		ANK repeat	503..539	CDD:293786	6/35 (17%)
		ANK	536..660	CDD:238125	23/135 (17%)
		ANK repeat	541..572	CDD:293786	8/37 (22%)
		ANK repeat	574..637	CDD:293786	8/62 (13%)
		Ank_2	579..670	CDD:289560	19/96 (20%)
		ANK repeat	639..670	CDD:293786	11/36 (31%)
		Ank_2	644..752	CDD:289560	23/117 (20%)
		ANK repeat	672..721	CDD:293786	10/56 (18%)
		ANK	721..843	CDD:238125	15/79 (19%)
		ANK repeat	723..752	CDD:293786	4/28 (14%)
		ANKYR	752..977	CDD:223738	11/48 (23%)
		ANK repeat	754..786	CDD:293786	8/37 (22%)
		ANK	820..944	CDD:238125
		ANK repeat	822..855	CDD:293786
		ANK repeat	857..888	CDD:293786
		ANK	885..1017	CDD:238125
		ANK repeat	890..921	CDD:293786
		ANK repeat	923..955	CDD:293786
		ANK repeat	996..1021	CDD:293786
		FYVE_ANFY1	1054..1116	CDD:277267
LOC100490559	XP_031750905.1	zf-C2H2	539..561	CDD:395048	5/21 (24%)
		C2H2 Zn finger	541..559	CDD:275368	5/17 (29%)
		C2H2 Zn finger	569..589	CDD:275368	3/25 (12%)
		COG5048	<597..744	CDD:227381	36/189 (19%)
		C2H2 Zn finger	597..617	CDD:275368	4/37 (11%)
		C2H2 Zn finger	625..645	CDD:275368	7/20 (35%)
		zf-H2C2_2	637..662	CDD:404364	8/28 (29%)
		C2H2 Zn finger	653..673	CDD:275368	3/21 (14%)
		C2H2 Zn finger	681..701	CDD:275368	5/19 (26%)
		C2H2 Zn finger	709..729	CDD:275368	5/33 (15%)
		C2H2 Zn finger	737..757	CDD:275368	4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1115202at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010