DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG41099 and ankk1

DIOPT Version :9

Sequence 1:	NP_001015359.1	Gene:	CG41099 / 3355072	FlyBaseID:	FBgn0039955	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_001124137.1	Gene:	ankk1 / 100170831	ZFINID:	ZDB-GENE-071015-4	Length:	733	Species:	Danio rerio

Alignment Length:	925	Identity:	203/925 - (21%)
Similarity:	341/925 - (36%)	Gaps:	304/925 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 DWSDLNE-------DVVLSLLR---WIYTDLIDLQNDGLALDLLKAAH-RFG-LPSLLGICE--R 161
            ||..|.|       .|.|.:||   .:.|...|.:|   .:::.|... :|. |.|:.|||:  .
Zfish    31 DWEKLVERKFGRVYKVKLKVLRETCALKTTTNDYRN---IMEISKIGRMKFNYLISIYGICKDPP 92

  Fly   162 ALVTSVGVRSCIRFYCVAEEVGASTLLEY-----CSSIISTH---WDDLTTDDFQHMSGPLLFEM 218
            |||                       :||     ..:::|.|   |             |..|:|
Zfish    93 ALV-----------------------MEYMRKGSLDNLLSNHLLMW-------------PKKFQM 121

  Fly   219 LKTKT---------KHP-LHAAVR---LLREDVVSLCIQKYGNSLVNTFSENGILPLEMALSSKN 270
            :...|         |.| ||..::   :|.:|.:.:.|..:|.             ::...|||
Zfish   122 IHEMTMGMNFLHSMKPPILHLNLKPANILLDDHLHVKISDFGF-------------IKWEFSSK- 172

  Fly   271 AKIAKSLVDNGMANINAVNMEGFSLLKSALKNG---DAFSANFLLDQNCLLDLPSKPS----SDT 328
            .:..:.|:..|  |||.|..|  :|.::....|   |.:|.:.::.:    .|..|.|    |.|
Zfish   173 TEFIEHLMARG--NINYVPPE--TLSQNPEPPGTKYDVYSFSIIMWE----ILTQKRSYAGLSMT 229

  Fly   329 ALHIICNYG--------PDNTPEIMEVVKKILQRQLNINIQNIKGETPLHIAIARRNVEMVKLLL 385
            .:.|..:.|        |::.|...|.:..::|:..|   |:.:...|....:  |..|::..:|
Zfish   230 EILIRVSSGKRPGVEKIPEDKPPECEDMIGVMQQCWN---QDSRSRPPFSKTV--RLTEVLSEVL 289

  Fly   386 KVPNIDINLRTYDEKCALELSLSMGDHEFLIASILLSMGARTDRTNSKTGDSLLQVFALDRHRGE 450
            |:|:      |:..:                 .|...:..:..:|...:.||.:|
Zfish   290 KIPD------TFSRR-----------------EIRKRLPEQPKKTADSSDDSSIQ---------- 321

  Fly   451 KSAIFLADFADLDHINFRGLTALHIAALNNMPNLVKKLIVNGASSNLKHIDCGLK---SALHIAV 512
             |.:...||                   |:...:|:|          :|:....:   |.||.||
Zfish   322 -SLLVRKDF-------------------NSFKKVVRK----------EHVSMLFQDNNSLLHHAV 356

  Fly   513 EANAIDALEAFVELKNKSHDIDFNCQDINGDSPLSLCLSLKRTTLVPTLIRGGSDVNGKNKNNLS 577
            .....::::..:.|     ....|||.:.|.:||.:.:..|...:...|...|:|||..:.:..:
Zfish   357 AGGDRESVQMVLNL-----GASVNCQSVKGYTPLIVAVLHKFYEICSLLTDCGADVNLSDGDQWT 416

  Fly   578 PLHQSIKNEDSDISLFLLEQGADITALTENLDSALDLSIKHDLSEVVDALCRRGIALSINKNGES 642
            .||.:::..|...:.|||:..|                 :.|..|               |:|.:
Zfish   417 ALHFAVQAGDDRATRFLLDNKA-----------------RADAKE---------------KDGWT 449

  Fly   643 PLWSALEKGYEDVAKILVRHGIDTDCWDEGPEGCRQTLLHRAIDENKESVAIFLIQSQCDLDSSR 707
            ||..|.:.|:|::.:||:|.....|..:.  :.|| |.||.|......::...|:....|:|.
Zfish   450 PLHLAAQNGHENIVRILLRRLDSVDVQEH--QSCR-TALHVASIYGHINIVKLLLNKGADIDK-- 509

  Fly   708 QPGPNGEGGDEAQDKASPLHLCCHWGQTKVLQTLIDHGANVNLIDAESKSPLHVAIESQYDEIIS 772
                      :..::::.|||....|..:|::.|::.||:||.:|.:|.|.||.|..:.|..|..
Zfish   510 ----------QDNNQSTALHLAAEEGHFRVVRLLVNSGADVNKVDEQSYSSLHFAALNGYTGICR 564

  Fly   773 ILLC-----------------------HPDIDLKLRDKSGNTPFATALDFRNHNAAQRILDRFPT 814
            :||.                       ||:|.|.|.:..|:
Zfish   565 LLLSKGIDPNSRTNKNWTAMHLAALKGHPEIILTLEEHQGS------------------------ 605

  Fly   815 AAEQMDIRGRNF---LHLAILKDDLESVLFLLAIQVDVNSRVHDANQSSPLHLAAASQNEMITRN 876
                ::|:|:|.   ||||......|.|..||....|.|  :.:.|..:|||||..|.:......
Zfish   606 ----VNIQGKNGWTPLHLACHHGQEEVVTGLLTAGADPN--LAEDNGWTPLHLACNSSSFPSVLQ 664

  Fly   877 LILAGARMNERDAVQKLPLHIAIERGNLPAVSALIQNNADYDATDADGNNALHIAVRCAQFFIVR 941
            ||...|.:|.::..|..|||:|.:..|:|.:.||:.|||..:..|:.|..||.:|.:|.
Zfish   665 LISHKANVNAQNNSQSTPLHLAAQLSNIPIIKALLMNNAQREMQDSKGCTALTLAQQCN------ 723

  Fly   942 ELLTESRVNAEATNL 956
                    |:||..|
Zfish   724 --------NSEAVEL 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG41099	NP_001015359.1	BTB	67..164	CDD:279045	19/66 (29%)
		BTB	75..166	CDD:197585	21/68 (31%)
		ANK	252..385	CDD:238125	30/147 (20%)
		ANK repeat	291..322	CDD:293786	6/33 (18%)
		ANK repeat	325..362	CDD:293786	10/48 (21%)
		Ank_2	330..431	CDD:289560	16/108 (15%)
		ANK	463..595	CDD:238125	26/134 (19%)
		ANK repeat	468..501	CDD:293786	4/32 (13%)
		Ank_2	473..572	CDD:289560	22/101 (22%)
		ANK repeat	503..539	CDD:293786	8/38 (21%)
		ANK	536..660	CDD:238125	29/123 (24%)
		ANK repeat	541..572	CDD:293786	9/30 (30%)
		ANK repeat	574..637	CDD:293786	9/62 (15%)
		Ank_2	579..670	CDD:289560	20/90 (22%)
		ANK repeat	639..670	CDD:293786	10/30 (33%)
		Ank_2	644..752	CDD:289560	27/107 (25%)
		ANK repeat	672..721	CDD:293786	9/48 (19%)
		ANK	721..843	CDD:238125	35/147 (24%)
		ANK repeat	723..752	CDD:293786	10/28 (36%)
		ANKYR	752..977	CDD:223738	62/231 (27%)
		ANK repeat	754..786	CDD:293786	14/54 (26%)
		ANK	820..944	CDD:238125	42/126 (33%)
		ANK repeat	822..855	CDD:293786	12/35 (34%)
		ANK repeat	857..888	CDD:293786	11/30 (37%)
		ANK	885..1017	CDD:238125	23/72 (32%)
		ANK repeat	890..921	CDD:293786	12/30 (40%)
		ANK repeat	923..955	CDD:293786	8/31 (26%)
		ANK repeat	996..1021	CDD:293786
		FYVE_ANFY1	1054..1116	CDD:277267
ankk1	NP_001124137.1	PKc_like	32..289	CDD:304357	67/322 (21%)
		STYKc	33..276	CDD:214568	64/306 (21%)
		ANK repeat	347..378	CDD:293786	8/35 (23%)
		Ank_2	352..443	CDD:289560	25/112 (22%)
		ANK	375..501	CDD:238125	38/160 (24%)
		ANK repeat	381..411	CDD:293786	9/29 (31%)
		ANK repeat	413..444	CDD:293786	8/47 (17%)
		Ank_2	418..511	CDD:289560	29/139 (21%)
		ANK	441..567	CDD:238125	40/155 (26%)
		ANK repeat	446..477	CDD:293786	10/30 (33%)
		ANK repeat	479..511	CDD:293786	9/44 (20%)
		Ank_2	485..576	CDD:289560	26/102 (25%)
		ANK	508..629	CDD:238125	35/160 (22%)
		ANK repeat	513..544	CDD:293786	10/30 (33%)
		ANK repeat	546..576	CDD:293786	9/29 (31%)
		Ank_2	551..641	CDD:289560	26/119 (22%)
		ANK repeat	581..610	CDD:293786	7/56 (13%)
		ANK	607..731	CDD:238125	46/140 (33%)
		ANK repeat	612..643	CDD:293786	11/32 (34%)
		Ank_2	617..709	CDD:289560	33/93 (35%)
		ANK repeat	645..676	CDD:293786	11/30 (37%)
		ANK repeat	678..709	CDD:293786	12/30 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900