DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG41099 and zfyve1

DIOPT Version :9

Sequence 1:	NP_001015359.1	Gene:	CG41099 / 3355072	FlyBaseID:	FBgn0039955	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	XP_001344703.1	Gene:	zfyve1 / 100005732	ZFINID:	ZDB-GENE-131205-1	Length:	779	Species:	Danio rerio

Alignment Length:	748	Identity:	148/748 - (19%)
Similarity:	240/748 - (32%)	Gaps:	262/748 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   501 DCGLKSALHIAVEANAIDALEAFVELKNKSHDIDFNCQDINGDS-----------------PLSL 548
            :||....:...:|.:..|.:.....::.....:.: |....||.                 .::|
Zfish    36 ECGSLQCIRCELELHRQDRMRNHDRIRIAPGHVPY-CDSCKGDGGVPNGGRLRAVVRCQGCKINL 99

  Fly   549 CLSLKRTTLVPTLIRGGSDVNGKNKNNLSPLHQSIKNEDSDISLFLLEQGADITALTENLDSAL- 612
            ||..::.|        .|.|: |.|:.|:......|..:::.|.. .||..::.|..|.:.|.|
Zfish   100 CLDCQKRT--------HSGVS-KRKHPLTAYPPPSKPPENNCSTG-DEQLDELKAKLEKVTSFLL 154

  Fly   613 -----DLSIKHDLSEVVDALCRRGIALSI----NKNGE-------------------SP------ 643
                 |:.:|::...|....||....|.:    ...||                   ||
Zfish   155 VDENEDMQVKNEEDFVRKLGCRPEELLKVVSIFGNTGEGKSHTLNHTFFLGREVFKTSPTQESCT 219

  Fly   644 --LWSALEKGYEDVAKILVRHGIDTDCWDEGPEGCRQTLLHRAIDENKESVAIFLIQSQCDLDSS 706
              :|:|:    :.|.|::|   :||       ||    ||....::.:.:..:..:.:..||...
Zfish   220 VGVWAAM----DPVHKVVV---VDT-------EG----LLGAGTNQGQRTRLLLKVLAVSDLVIY 266

  Fly   707 RQPGPNGEGGDEAQD-------KASPLHLCCHWGQTKVLQ-TLIDHGANVNLIDAESKSPLHVAI 763
            |      ...|...|       .||..:| .|:  ||.|: |....|.:|.|   .:..|
Zfish   267 R------THADRLHDDLFKFLGDASDAYL-KHF--TKELKATTARCGLDVPL---STLGP----- 314

  Fly   764 ESQYDEIISILLCHPDIDLKL--RDKSGNTPFATALDFRNHNAAQRILDR-------FPTAAEQM 819
                    ::::.|..:..||  .||..             .:|:|:|..       ||.|...:
Zfish   315 --------AVIIFHETVHTKLLGSDKPS-------------ESAERLLQERFRKLGLFPEAFSSI 358

  Fly   820 DIRGRNFLHLAILKDDLESVLFLLAIQVDVNSR--------VHDANQS---------SPLHLAAA 867
            ..||.. .|..  ..|...:|..:..|:|.||.        :|.|.|:         ...|||:.
Zfish   359 QYRGTR-THNP--PTDFSGLLRSVEQQLDNNSTRSPRSAGVIHKALQALSECFSGEIPDEHLASN 420

  Fly   868 S--QNEMITRNLIL----AGARMNERDAVQKLPLHIAIERGNLPAVSALIQNNADYDATDADGNN 926
            |  .:|..|.:.|.    :|.: |..:.:::..:|.|..|         .:.:|.||       |
Zfish   421 SFFPDEYFTCSSICLSCGSGCK-NSMNHLREGVVHEAKHR---------CRYSAHYD-------N 468

  Fly   927 ALHIAVRCAQFFIVRELLTESRVNAEATNLKGRNPLHELCRVVEDSTAGLICELF---LESMPKY 988
            .::....|.:                    .|:..:     ||..:||......|   :.:...|
Zfish   469 RIYTCKACYE--------------------SGKEVI-----VVPKTTASSDSPWFGLAIYAWSGY 508

  Fly   989 PINIPDMD----------GNTPLLLSFMR--------GQSPLCKILVKAGACLGTENKDGINIFN 1035
            .|..|:..          ||...:.:.:|        |.....|....|...|    .||:|...
Zfish   509 VIECPNCSVIYRSRQYWYGNQDPVDTVVRTEIQHVWPGSDKFLKDNNNAAQRL----LDGVNFMA 569

  Fly  1036 FKLA--------------TDQLLHNLLDQLPQESP--WAESDY---CQHCTNRFTITMRKHHCRH 1081
            ..::              |||:           :|  |..:..   |..|...|.....|||||.
Zfish   570 QSVSELSVKPAKAVTAWLTDQI-----------APAYWKPNSLILRCYKCGAGFEDNDTKHHCRA 623

  Fly  1082 CGRVLCSKCSCNDVPILKFGIN-KPVRVCTVCF 1113
            ||...|..||....|:.:.|.. .|||||..||
Zfish   624 CGEGFCDGCSSKTRPVPERGWGLAPVRVCDACF 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG41099	NP_001015359.1	BTB	67..164	CDD:279045
		BTB	75..166	CDD:197585
		ANK	252..385	CDD:238125
		ANK repeat	291..322	CDD:293786
		ANK repeat	325..362	CDD:293786
		Ank_2	330..431	CDD:289560
		ANK	463..595	CDD:238125	18/110 (16%)
		ANK repeat	468..501	CDD:293786	148/748 (20%)
		Ank_2	473..572	CDD:289560	13/87 (15%)
		ANK repeat	503..539	CDD:293786	4/35 (11%)
		ANK	536..660	CDD:238125	34/177 (19%)
		ANK repeat	541..572	CDD:293786	8/47 (17%)
		ANK repeat	574..637	CDD:293786	15/72 (21%)
		Ank_2	579..670	CDD:289560	25/127 (20%)
		ANK repeat	639..670	CDD:293786	11/57 (19%)
		Ank_2	644..752	CDD:289560	27/115 (23%)
		ANK repeat	672..721	CDD:293786	8/48 (17%)
		ANK	721..843	CDD:238125	29/138 (21%)
		ANK repeat	723..752	CDD:293786	11/29 (38%)
		ANKYR	752..977	CDD:223738	46/256 (18%)
		ANK repeat	754..786	CDD:293786	4/33 (12%)
		ANK	820..944	CDD:238125	29/146 (20%)
		ANK repeat	822..855	CDD:293786	9/40 (23%)
		ANK repeat	857..888	CDD:293786	10/45 (22%)
		ANK	885..1017	CDD:238125	23/152 (15%)
		ANK repeat	890..921	CDD:293786	6/30 (20%)
		ANK repeat	923..955	CDD:293786	2/31 (6%)
		ANK repeat	996..1021	CDD:293786	6/42 (14%)
		FYVE_ANFY1	1054..1116	CDD:277267	24/66 (36%)
zfyve1	XP_001344703.1	GBP	175..411	CDD:206650	58/294 (20%)
		PHD_SF	595..656	CDD:304600	21/60 (35%)
		FYVE_ZFYV1	713..773	CDD:277273
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1818
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900