DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17684 and dpp9

DIOPT Version :9

Sequence 1:	NP_001015352.3	Gene:	CG17684 / 3355066	FlyBaseID:	FBgn0263780	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	XP_031757283.1	Gene:	dpp9 / 779598	XenbaseID:	XB-GENE-947854	Length:	856	Species:	Xenopus tropicalis

Alignment Length:	774	Identity:	174/774 - (22%)
Similarity:	290/774 - (37%)	Gaps:	211/774 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 PVKLKDTLKVQRTRLQYASWLGNTTAIIFVVKNDIFIRQSPLVEEDIRITSSGH-------ENHI 240
            |:::|  .:....|:.......|...|.|:..:|::|.....:||. |:|.. |       ::..
Frog   174 PIEIK--TRCDGPRMDPKICPANPNFISFINNSDLWIENIHTMEEQ-RLTYC-HKGLRCVMDDPC 234

  Fly   241 YNGVPDWLYQEEIFETPEAIWTSSDGT---------HFMYALFNDTNVGMMTYPWLSSGALFSGS 296
            ..|:..::.||| |:.....|.|....         ..:|...::::|.::..|   |.||..
Frog   235 SAGIATFVIQEE-FDRFTGYWWSPTAVDLPGGFSVLRILYEEVDESDVEIIHVP---SPALEE-- 293

  Fly   297 GIFSGSIFPETKMVRFPTPGTTNPEVELWAVDITNLSDIQ------KFNIKPPATIYGQDYYLTS 355
                    .:|...|:|..|:.||::.|...:||..:|.:      |..:.|..:::....|:..
Frog   294 --------RKTDAYRYPRTGSKNPKITLKLSEITTNNDGEIVAAQDKELVLPFHSLFPSAEYIVR 350

  Fly   356 AGWISDS-----------NCQVSVVYMGRSQNYSVISLCSKEEDWK--CLEVHSERAP------- 400
            |||..|.           .|.:.:|.:...   ..|.:|..||..|  ..||.....|
Frog   351 AGWAKDGKFAWAMLLDRPQCLLQLVLLPPE---LFIPVCEDEEQRKQYVKEVPPHIQPYVIYEEK 412

  Fly   401 EDEWLDIFPHPVF------SSDGSSFL-------------FLANIQESENYQFTHIKHVMISQRR 446
            .|.|:::  |.||      ..|..||:             .:.::.::|:.:::.    |||...
Frog   413 SDTWVNV--HDVFHLLRQEKEDEISFICSSESQTEFCHLYLMTSLLQNEHREWSQ----MISPCT 471

  Fly   447 ISVIS-HGRYEVT------KILC------W-DTINHKVYFMATQDKKPGQRHLY--SVQDPIHDD 495
            :.:.. |.:.||.      ::||      | :.....|||..|:| .|.:.|||  |.|:| .:.
Frog   472 VEMFKCHIKQEVALTSGDWEVLCRHGAKVWVNEATQLVYFQGTKD-TPLEHHLYVTSYQNP-GEV 534

  Fly   496 IRKVEPQCITCDLGDDLWSSRYYYTNCT---HFEAFITPSLGVATNYGIEFYILECQGPGLPVSG 557
            :|..|               |.|..:||   :|:.|::....|:....:..|.|.    |.|
Frog   535 VRLTE---------------RGYSHSCTMSPNFDVFVSQYSSVSCPPCVHLYRLN----GNP--- 577

  Fly   558 VHMQTTHSLVKILYDTRPFYTERLQKLALPT----------QRSFEVPL------PHGGRAQVQL 606
                        ||....|:...::....|.          |.|.:|.|      ||.
Frog   578 ------------LYQQPQFWASVMEAARCPPYYVPPEIFHFQASSQVKLYGMVYKPHN------- 623

  Fly   607 LLPPSWREELRDAAFPVIVEVNGRPGSESVSEKFKIDWGTYMSSRNDVVYIRL------------ 659
            |:|        ....|.::.|.|.|..:.|:..||           .:.|:||
Frog   624 LVP--------GTKHPTVLFVYGGPQVQLVNNSFK-----------GMKYLRLNTLAHLGYAVVV 669

  Fly   660 -DVRGSKGQS---KKTLYRHLGGVEVLDQISVIGYLLDTIGFLDETRVGMWGWGYGGYVTSMALG 720
             |.|||..:.   :..|...:|.||:.||:..:.::.:..||:|..||.:.||.|||:::.|.:.
Frog   670 IDGRGSCHRGLVFEGALKNKMGQVEIQDQVEGLHFVAERFGFVDLDRVAIHGWSYGGFLSLMGII 734

  Fly   721 TQQDVFKCGIAVSPTADWL-YST-FTERILGLPAENFKGYVEADATQRARLIKSNSY--FLIHGL 781
            .:.:|||..||.:|...|: |.| :|||.:..|..|..||....|......:.:..:  .::||.
Frog   735 QRPEVFKVAIAGAPVTLWMAYDTGYTERYMDTPVNNQVGYEAGSAALHVDKLPNEPHRLLILHGF 799

  Fly   782 ADTTAPFVHGVQLAKSLTSANILFRYQTYADEGHDL----SGVLEHVYSSMEQYFAECL 836
            .|....|.|...|...|..|...::.|.|.:|.|.:    ||  ||...::..:..|.|
Frog   800 LDENVHFFHTNFLLSQLIRAGKPYQLQIYPNERHSIRCPESG--EHYEITLLHFLQEHL 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17684	NP_001015352.3	DPPIV_N	147..554	CDD:279298	95/450 (21%)
CG17684	NP_001015352.3	Abhydrolase	643..836	CDD:304388	58/216 (27%)
dpp9	XP_031757283.1	DPPIV_N	143..566	CDD:395744	92/435 (21%)
dpp9	XP_031757283.1	Peptidase_S9	655..856	CDD:395257	57/202 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910