Protein Alignment CG17684 and Dpp8

DIOPT Version :10

• Sequence 1: NP_001015352.3
• Gene: CG17684 / 3355066
• FlyBaseID: FBgn0263780
• Length: 855
• Species: Drosophila melanogaster
• Sequence 2: NP_083182.2
• Gene: Dpp8 / 74388
• MGIID: 1921638
• Length: 892
• Species: Mus musculus
• Alignment Length: 765
• Identity: 177/765 - (23%)
• Similarity: 280/765 - (36%)
• Gaps: 241/765 - (31%)

  Fly   209 IIFVVKNDIFIRQSPLV-EEDIRITSSGHENHIYN------------GVPDWLYQEEI------F 254
            |.|:..|||:|  |.|| .|:.|||      :::|            ||..::.|||.      :
Mouse   222 IAFIHSNDIWI--SNLVTREERRIT------YVHNELANMEEDPRSAGVATFVLQEEFDRYSGYW 278

  Fly   255 ETPEAIWTSSDG--THFMYALFNDTNVGM--MTYPWLSSGALFSGSGIFSGSIFPETKMV---RF 312
            ..|:|..|.|.|  ...:|...:::.|.:  :|.|.|                  ||:..   |:
Mouse   279 WCPQAERTPSGGKILRILYEENDESEVEIIHVTSPML------------------ETRRADSFRY 325

  Fly   313 PTPGTTNPEVEL-----------WAVDITNLSDIQKFNIKPPATIYGQDYYLTSAGWISDSNCQV 366
            |..||.||:|..           ..:|:.:...:|.|.|     ::....|:..|||..:.....
Mouse   326 PKTGTANPKVTFKMSEIVVDAAGGIIDVIDKELVQPFEI-----LFEGVEYIARAGWTPEGKHAW 385

  Fly   367 SVVYMGRSQNYSVISLCSK------EEDWKCLEVHSERAPE------------DEWLDIFPHPVF 413
            |:: :.|||.:..|.|.|.      |:|....:...|..|:            |.|::|  |.:|
Mouse   386 SIL-LDRSQTHLQIVLISPELFIPVEDDAMDRQRLIESVPDSVTPLIIYEETTDIWINI--HDIF 447

  Fly   414 ------SSDGSSFLFLANIQESENYQFTHIKHVMISQRRISVISHGRY----------------- 455
                  ..|...|:|.:..:..    |.|:..:      .|::...:|
Mouse   448 HVFPQTHEDEIEFIFASECKTG----FRHLYKI------TSILKESKYKRSSGGLPAPSDFKCPI 502

  Fly   456 --EVT------KIL------CW-DTINHKVYFMATQDKKPGQRHLYSVQDPIHDDIRKVEPQCIT 505
              |:|      ::|      .| |.....|||..|:| .|.:.|||........::.::
Mouse   503 KEEITITSGEWEVLGRHGSNIWVDEARKLVYFEGTKD-SPLEHHLYVTSYANPGEVVRL------ 560

  Fly   506 CDLGDDLWSSRYYYTNC---THFEAFITPSLGVATNYGIEFY-------------------ILEC 548
                    :.|.|..:|   .|.:.||:........:.:..|                   ||:.
Mouse   561 --------TDRGYSHSCCLSRHCDFFISKYSNQKNPHCVSLYKLSSPEDDPVHKTKEFWATILDS 617

  Fly   549 QGPGLP------VSGVHMQTTHSLVKILYDTRPFYTERLQKLALPTQRSFEVPLPHGGRAQVQLL 607
            .|| ||      :......|..:|..:||.                        ||.
Mouse   618 AGP-LPDYTPPEIFSFESTTGFTLYGMLYK------------------------PHD-------- 649

  Fly   608 LPPSWREELRDAAFPVIVEVNGRPGSESVSEKFKIDWGTYMSSRNDV-----VYIRLDVRGS--K 665
            |.|..:       :|.::.:.|.|..:.|:.:||   |......|.:     |.:.:|.|||  :
Mouse   650 LQPGKK-------YPTVLFIYGGPQVQLVNNRFK---GVKYFRLNTLASLGYVVVVIDNRGSCHR 704

  Fly   666 GQSKKTLYRH-LGGVEVLDQISVIGYLLDTIGFLDETRVGMWGWGYGGYVTSMALGTQQDVFKCG 729
            |...:..::: :|.:|:.||:..:.||.....|:|..|||:.||.||||::.|||..:.|:|:..
Mouse   705 GLKFEGAFKYKMGQIEIDDQVEGLQYLASQYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVA 769

  Fly   730 IAVSPTADWL-YST-FTERILGLPAENFKGYVEADATQRARLIKS--NSYFLIHGLADTTAPFVH 790
            ||.:|...|: |.| :|||.:|.|.:|.:||.......:|....|  |...|:||..|....|.|
Mouse   770 IAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAH 834

  Fly   791 GVQLAKSLTSANILFRYQTYADEGHDL----SGVLEHVYSSMEQYFAECL 836
            ...|...|..|...:..|.|..|.|.:    ||  ||....:..|..|.|
Mouse   835 TSILLSFLVRAGKPYDLQIYPQERHSIRVPESG--EHYELHLLHYLQENL 882

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17684	NP_001015352.3	DPPIV_N	147..554	CDD:395744	94/459 (20%)
		Peptidase_S9	643..836	CDD:459761	66/208 (32%)
Dpp8	NP_083182.2	Dpp_8_9_N	1..156	CDD:466112
		DPPIV_N	169..589	CDD:395744	89/425 (21%)
		Peptidase_S9	681..885	CDD:459761	66/204 (32%)