DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17684 and dpp6b

DIOPT Version :9

Sequence 1:	NP_001015352.3	Gene:	CG17684 / 3355066	FlyBaseID:	FBgn0263780	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_001108594.1	Gene:	dpp6b / 566832	ZFINID:	ZDB-GENE-070705-88	Length:	868	Species:	Danio rerio

Alignment Length:	884	Identity:	261/884 - (29%)
Similarity:	419/884 - (47%)	Gaps:	123/884 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RSGGGGGSWRLPPDETLQVQDPKQKDHDFDFDEG----HNWRSIILSLLVISFVVSGIVTAIYLL 69
            |.|||.||   ....:||.|.....|::.:...|    .||:.|.::||||..:.|.|||::.||
Zfish    56 RGGGGAGS---GGRGSLQKQARMDADNEGELVGGSAPQRNWKGIAIALLVILVICSLIVTSVILL 117

  Fly    70 GYVDELLYWSGRRMILDEYLQGDLIPRRLPSSWVTTQKYVFQSDDGSLAVLDTTTNLVKVLVTNH 134
            ..|::....|.:::.:::...|.|......::|::..:.::...||::.:|:..||..|.||.|.
Zfish   118 TPVEDTSLASKQKVTIEDIFSGKLQAHNPQATWLSDTELLYHDHDGNVKMLNIQTNYNKTLVENK 182

  Fly   135 TLRQLNVRRYLCSSDLKYVLFTHNVKKNFQKSFTAFYTIYDVTNDHHTPVKLKDTLKVQRTRLQY 199
            |.......:|..|.||||||..:|:...:|.||.|:|.|..:  |....|:|... :||.|.|||
Zfish   183 TFETYRPTQYQVSPDLKYVLLAYNIMPIYQYSFMAYYIICSL--DSPERVELTPN-EVQSTALQY 244

  Fly   200 ASWLGNTTAIIFVVKNDIFIR---QSPLVEEDIRITSSGHENHIYNGVPDWLYQEEIFETPEAIW 261
            |.|......:||:.:|:|:.:   .||    .||:.|:|....|:||:.||||:||||:...|.|
Zfish   245 AGWGPKGQQLIFIFENNIYYKAQVNSP----SIRLVSTGSLGVIFNGLADWLYEEEIFQNHIAHW 305

  Fly   262 TSSDGTHFMYALFNDTNVGMMTYPWLSSGALFSGSGIFSGSIFPETKMVRFPTPGTTNPEVELWA 326
            .|.||....||..|||.|..|..|            :|:..::|..:..|:|..|..|||:.|..
Zfish   306 WSPDGLRLAYATINDTLVPKMEIP------------MFTSVLYPNGQEYRYPKAGEENPEIYLSV 358

  Fly   327 VDITNLSDIQKFNIKPPATIYGQDYYLTSAGWISDSNCQVSVVYMGRSQNYSVISLCSKEEDWKC 391
            |.:.......:.. ||......:|||:|...|.:.:  :::|.::.|:||.|:::|| :.....|
Zfish   359 VSLNGPLHTVRMK-KPEDPRIRKDYYITMVKWATST--KLAVNWLNRAQNSSILTLC-EATTGIC 419

  Fly   392 LEVHSERAPEDEWLDIFPH-----PVFSSDGSSFLFLANIQESENYQFTHIKHVMISQRRISV-- 449
            .:.|.:.:  |.||    |     |:||.||..|.|...:.:....:|.||. :..||...|.
Zfish   420 TKKHEDES--DSWL----HRQNEPPLFSKDGYRFFFTRAVPQGGRGKFFHIS-MSTSQPNSSTDT 477

  Fly   450 ---ISHGRYEVTKILCWDTINHKVYFMATQDKKPGQRHLYSVQDPIHDDIRKVEPQCITCDLGDD 511
               ::.|.::||:||.::.....|||::|:| ...:|.|||.     :.......:|::|:.
Zfish   478 LQSLTSGDWDVTQILAYNEDTRIVYFLSTED-GASRRQLYSA-----NTTGSFNRRCLSCNF--- 533

  Fly   512 LWSSRYYYTNCTHFEAFITPSLGVATNYGIEFYILECQGPGLPVSGVHMQTTHSLVKILYDTRPF 576
                     .|    .:::.|.....||    :.|.|:|||:|         ||.|   |.||..
Zfish   534 ---------RC----GYVSGSFSPDANY----FFLNCKGPGVP---------HSAV---YSTRYG 569

  Fly   577 YTERL-----QKLALPTQRSFEVPLPHGGRAQV-------QLLLPPSWREELRDAAFPVIVEVNG 629
            ..|::     .:|...|..:.::|:.......:       |:|.|..:   :..:.:|:::.|:|
Zfish   570 QYEKILDVETNELLNVTVNNTQMPIVEYRNVNIDDYVLSMQILKPAVF---VATSHYPLLLLVDG 631

  Fly   630 RPGSESVSEKFKIDWGTYMSSRNDVVYIRLDVRGSKGQSKKTLYR---HLGGVEVLDQISVIGYL 691
            .||.:.|:|:|::||.|.:.|..:.:.:|||.|||..|....|:|   .||..|..|.:..: .:
Zfish   632 TPGGQMVTEQFQVDWSTVLVSSFNTIVVRLDGRGSGFQGTNLLHRVKKKLGEFEERDHLEAL-RI 695

  Fly   692 LDTIGFLDETRVGMWGWGYGGYVTSMALGTQQD------VFKCGIAVSPTADW-LY-STFTERIL 748
            :..:.::|.:|:|::|..||||:.|..|...:.      ..|||.||||..|: :| |.|:||.|
Zfish   696 MSQMTYIDNSRIGVYGKAYGGYLASRLLHLDESPNLSKIKIKCGTAVSPITDFSIYASAFSERYL 760

  Fly   749 GLPAENFKGYVEADATQRARLIKSNSYFLIHGLADTTAPFVHGVQLAKSLTSANILFRYQTYADE 813
            |||..|.:.|..|..|.|...::.....:||..||....|.|..:....|.:....:..|.|.||
Zfish   761 GLPQINKREYEMARLTDRMEQLRDKKLMIIHPTADEKVHFQHTAKFINHLINEKANYTLQIYPDE 825

  Fly   814 GHDLSG--VLEHVYSSMEQYFAECLSLDPDDTKPEVDNS 850
            ||.|:.  ..:|:..|:..:|.||.      |.||:..|
Zfish   826 GHFLNSKDSQQHLSQSLVNFFVECF------TPPEIIQS 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17684	NP_001015352.3	DPPIV_N	147..554	CDD:279298	127/419 (30%)
CG17684	NP_001015352.3	Abhydrolase	643..836	CDD:304388	67/205 (33%)
dpp6b	NP_001108594.1	DPPIV_N	195..560	CDD:279298	128/429 (30%)
		DAP2	<433..850	CDD:224423	127/459 (28%)
		Abhydrolase	642..850	CDD:304388	68/208 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	181	1.000	Domainoid score	I3415
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100574
Panther	1	1.100	-	-	O	PTHR11731
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X274
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.780