DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17684 and dpp4

DIOPT Version :9

Sequence 1:	NP_001015352.3	Gene:	CG17684 / 3355066	FlyBaseID:	FBgn0263780	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	XP_012825865.2	Gene:	dpp4 / 548987	XenbaseID:	XB-GENE-976654	Length:	810	Species:	Xenopus tropicalis

Alignment Length:	819	Identity:	240/819 - (29%)
Similarity:	402/819 - (49%)	Gaps:	97/819 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 WRSIILSLLVISFVVSGIVTAIYLL---GYVDELLYWSGRRMILDEYLQGDLIPRRLPSSWVTTQ 106
            |...:|.:|:.:.||:.:...:.||   |..|     :.:...|::|...:...:.....||:..
Frog    63 WLKWLLGILMGAVVVTVVAVPVALLATKGKED-----TRKTFTLEDYFGDEYRAKSFGLKWVSEN 122

  Fly   107 KYVFQSDDGSLAVLDTTTNLVKVLVTNHTLRQLNVRRYLCSSDLKYVLFTHNVKKNFQKSFTAFY 171
            :::|::.|..| :.:........:::|.|:...|...|..|.:..|.|..:|.:|.::.|:||.|
Frog   123 EFLFRTKDNVL-IYNVDNEKTTEMISNTTIYNSNSSFYTLSDNRNYALLQYNYEKLWRHSYTASY 186

  Fly   172 TIYDVTNDHHTPVKLKDTLKVQRTRLQYASW--LGNTTAIIFVVKNDIFIRQSPLVEEDIRITSS 234
            .|||.......      |..|...::||.:|  :||..|  :|.:|:|:|:::| ....|:||::
Frog   187 HIYDTVKGEIV------TANVLPNQIQYITWSPVGNKLA--YVWENNIYIKETP-GGSSIQITTN 242

  Fly   235 GHENHIYNGVPDWLYQEEIFETPEAIWTSSDGTHFMYALFNDTNVGMMTYPWLSSGALFSGSGIF 299
            |..|.|.||:|||:|:||:|.|..|:|.|.|.....|..||||:|..:.|.       |.|.
Frog   243 GEHNKILNGIPDWVYEEEMFSTNYALWWSPDAASLAYVEFNDTDVPAIEYS-------FYGE--- 297

  Fly   300 SGSIFPETKMVRFPTPGTTNPEVELWAVDITNLSDIQKFNIKPPATIYGQDYYLTSAGWISDSNC 364
            ....:|:|.::.:|..|..||.|.|:.|:..:|.......|.|||.:...|||:....|:  :|.
Frog   298 DSDQYPKTVVIPYPKAGAKNPTVRLFVVNTASLPAFNSVEIPPPAELRTIDYYINGMNWV--TNG 360

  Fly   365 QVSVVYMGRSQNYSVISLCS-KEEDWKCLEVHSERAPEDEWLDIF--PHPVFSSDGSSFLFLANI 426
            :::|.::.|.||.|::::|. ....|.|.....|::... |:..|  ..|.|:.||..:..:.:.
Frog   361 KMAVQWLRRIQNVSLLTVCDFAAPAWNCQPPVYEQSTTG-WVGYFQPSSPYFTQDGQKYYKVISN 424

  Fly   427 QESENYQFTHIKHVMISQRRISVISHGRYEVTKILCWDTINHKVYFMATQDKKPGQRHLYSVQDP 491
            :|.    |.|| |:....:....|:.|::|||.|   .|:...:.:..:.:..||:|.||.
Frog   425 KEG----FKHI-HLFEGAKEPVAITSGKWEVTSI---TTVASNLLYYISNEGFPGRRQLYK---- 477

  Fly   492 IHDDIRKVEPQCITCDLGDDLWSSRYYYTNCTHFEAFITPSLGVATNYGIEFYILECQGPGLPV- 555
            |..|......||:||::..:         .|..:.|:.:..        .::|.|.|.|||:|:
Frog   478 IRLDGGSNSAQCVTCNIRQE---------RCQQYSAYFSKD--------SKYYALNCNGPGVPIY 525

  Fly   556 --------SGVHMQTTHSLVKILYDTRPFYTERLQKLALPTQRSFEVPLPHGGRAQVQLLLPPSW 612
                    ..:|:...:..:|:|.|          ::.:||:.:..: :..|.....||.|||::
Frog   526 TLYNSSNDKEMHIMEDNEELKLLLD----------EVQMPTKENKSI-IIDGFELWYQLTLPPNF 579

  Fly   613 REELRDAAFPVIVEVNGRPGSESVSEKFKIDWGTYMSSRNDVVYIRLDVRGSKGQSKK---TLYR 674
            .:..:   :|::::|.|.|.|:.|.:.|:::|.||::|...::....|.|||..|..|   .||.
Frog   580 DKSKK---YPLLIDVYGGPCSQKVDQYFRLNWATYLASTEKIIVASFDGRGSGYQGDKIMHQLYH 641

  Fly   675 HLGGVEVLDQISVIGYLLDTIGFLDETRVGMWGWGYGGYVTSMALGTQQDVFKCGIAVSPTADWL 739
            .||.:||.|||:...|.: |:||:|..|:.:|||.||||||||.||:...:|||||||:|.:.|.
Frog   642 KLGTLEVQDQIAAARYFI-TLGFVDPKRIAIWGWSYGGYVTSMVLGSGSGLFKCGIAVAPVSSWE 705

  Fly   740 Y--STFTERILGLPA--ENFKGYVEADATQRARLIKSNSYFLIHGLADTTAPFVHGVQLAKSLTS 800
            |  |.:|||.:|||.  :|.:.|:.:....||:..|...|.||||.||....|.....::|:|..
Frog   706 YYDSIYTERYMGLPTPEDNLENYLSSTVMARAQKFKDVEYLLIHGTADDNVHFQQAAHISKALVD 770

  Fly   801 ANILFRYQTYADEGHDLSGVL-EHVYSSMEQYFAECLSL 838
            |.:.|....|.|:.|.:.|.. .|:|:.|..|..:|.::
Frog   771 AQVDFDTMWYTDKDHGIGGTANRHIYTHMSHYLKQCFNI 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17684	NP_001015352.3	DPPIV_N	147..554	CDD:279298	119/411 (29%)
CG17684	NP_001015352.3	Abhydrolase	643..836	CDD:304388	80/200 (40%)
dpp4	XP_012825865.2	DPPIV_rep	94..114	CDD:408582	3/24 (13%)
		DPPIV_N	162..524	CDD:395744	119/412 (29%)
		Peptidase_S9	604..810	CDD:395257	82/207 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	1	1.000	-	-		otm48727
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X274
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920