Protein Alignment CG17684 and DPP8

DIOPT Version :10

• Sequence 1: NP_001015352.3
• Gene: CG17684 / 3355066
• FlyBaseID: FBgn0263780
• Length: 855
• Species: Drosophila melanogaster
• Sequence 2: NP_932064.1
• Gene: DPP8 / 54878
• HGNCID: 16490
• Length: 898
• Species: Homo sapiens
• Alignment Length: 853
• Identity: 193/853 - (22%)
• Similarity: 306/853 - (35%)
• Gaps: 266/853 - (31%)

  Fly   108 YVFQSDDGSLAVLD----------TTTNLVKVLVTNHTLRQLNVRRYLCSSDLKYVLFTHNVKKN 162
            ::||:..|...|.|          ...|||:....|     :.:...||.:|..::.|.|
Human   178 FLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPN-----IRMDPKLCPADPDWIAFIH----- 232

  Fly   163 FQKSFTAFYTIYDVTNDHHTPVKLKDTLKVQRTRLQYASWLGNTTAIIFVVKNDIFIRQSPLVEE 227
                          :||    :.:.:.:..:..||.|             |.|::     ..:||
Human   233 --------------SND----IWISNIVTREERRLTY-------------VHNEL-----ANMEE 261

  Fly   228 DIRITSSGHENHIYNGVPDWLYQEEIFETPEAIW------TSSDGTHFMYALFNDTNVGMMTYPW 286
            |.|..          ||..::.||| |:.....|      |:..|...:..|:.:.:...:....
Human   262 DARSA----------GVATFVLQEE-FDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIH 315

  Fly   287 LSSGALFSGSGIFSGSIFPETKMV---RFPTPGTTNPEV-----------ELWAVDITNLSDIQK 337
            ::|..|             ||:..   |:|..||.||:|           |...:|:.:...||.
Human   316 VTSPML-------------ETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQP 367

  Fly   338 FNIKPPATIYGQDYYLTSAGWISDSNCQVSVVYMGRSQNYSVISLCSKE----------EDWKCL 392
            |.|     ::....|:..|||..:.....|:: :.|||....|.|.|.|          |..:.:
Human   368 FEI-----LFEGVEYIARAGWTPEGKYAWSIL-LDRSQTRLQIVLISPELFIPVEDDVMERQRLI 426

  Fly   393 E----------VHSERAPEDEWLDIFPHPVF------SSDGSSFLFLANIQES--ENYQFTHI-- 437
            |          ::.|..  |.|::|  |.:|      ..:...|:|.:..:..  ..|:.|.|
Human   427 ESVPDSVTPLIIYEETT--DIWINI--HDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILK 487

  Fly   438 --KHVMIS-------------QRRISVISHGRYEVT----KILCWDTINHKVYFMATQDKKPGQR 483
              |:...|             :..|::.| |.:||.    ..:..|.:...|||..|:| .|.:.
Human   488 ESKYKRSSGGLPAPSDFKCPIKEEIAITS-GEWEVLGRHGSNIQVDEVRRLVYFEGTKD-SPLEH 550

  Fly   484 HLYSVQDPIHDDIRKVEPQCIT--CDLGDDLWSSRYYYTNC--THFEAFITPSLGVATNYGIEFY 544
            |||.|.        .|.|..:|  .|.|       |.::.|  .|.:.||:........:.:..|
Human   551 HLYVVS--------YVNPGEVTRLTDRG-------YSHSCCISQHCDFFISKYSNQKNPHCVSLY 600

  Fly   545 -------------------ILECQGPGLP------VSGVHMQTTHSLVKILYDTRPFYTERLQKL 584
                               ||:..|| ||      :......|..:|..:||.
Human   601 KLSSPEDDPTCKTKEFWATILDSAGP-LPDYTPPEIFSFESTTGFTLYGMLYK------------ 652

  Fly   585 ALPTQRSFEVPLPHGGRAQVQLLLPPSWREELRDAAFPVIVEVNGRPGSESVSEKFKIDWGTYMS 649
                        ||.        |.|..:       :|.::.:.|.|..:.|:.:||   |....
Human   653 ------------PHD--------LQPGKK-------YPTVLFIYGGPQVQLVNNRFK---GVKYF 687

  Fly   650 SRNDV-----VYIRLDVRGS--KGQSKKTLYRH-LGGVEVLDQISVIGYLLDTIGFLDETRVGMW 706
            ..|.:     |.:.:|.|||  :|...:..::: :|.:|:.||:..:.||.....|:|..|||:.
Human   688 RLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIH 752

  Fly   707 GWGYGGYVTSMALGTQQDVFKCGIAVSPTADWL-YST-FTERILGLPAENFKGYVEADATQRARL 769
            ||.||||::.|||..:.|:|:..||.:|...|: |.| :|||.:|.|.:|.:||.......:|..
Human   753 GWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEK 817

  Fly   770 IKS--NSYFLIHGLADTTAPFVHGVQLAKSLTSANILFRYQTYADEGHDL----SGVLEHVYSSM 828
            ..|  |...|:||..|....|.|...|...|..|...:..|.|..|.|.:    ||  ||....:
Human   818 FPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESG--EHYELHL 880

  Fly   829 EQYFAECL 836
            ..|..|.|
Human   881 LHYLQENL 888

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17684	NP_001015352.3	DPPIV_N	147..554	CDD:395744	99/498 (20%)
		Peptidase_S9	643..836	CDD:459761	66/208 (32%)
DPP8	NP_932064.1	Dpp_8_9_N	8..162	CDD:466112
		DPPIV_N	175..595	CDD:395744	105/513 (20%)
		Peptidase_S9	687..891	CDD:459761	66/204 (32%)