DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17684 and DPP8

DIOPT Version :9

Sequence 1:	NP_001015352.3	Gene:	CG17684 / 3355066	FlyBaseID:	FBgn0263780	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_001307804.1	Gene:	DPP8 / 54878	HGNCID:	16490	Length:	898	Species:	Homo sapiens

Alignment Length:	853	Identity:	193/853 - (22%)
Similarity:	306/853 - (35%)	Gaps:	266/853 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 YVFQSDDGSLAVLD----------TTTNLVKVLVTNHTLRQLNVRRYLCSSDLKYVLFTHNVKKN 162
            ::||:..|...|.|          ...|||:....|     :.:...||.:|..::.|.|
Human   178 FLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPN-----IRMDPKLCPADPDWIAFIH----- 232

  Fly   163 FQKSFTAFYTIYDVTNDHHTPVKLKDTLKVQRTRLQYASWLGNTTAIIFVVKNDIFIRQSPLVEE 227
                          :||    :.:.:.:..:..||.|             |.|::     ..:||
Human   233 --------------SND----IWISNIVTREERRLTY-------------VHNEL-----ANMEE 261

  Fly   228 DIRITSSGHENHIYNGVPDWLYQEEIFETPEAIW------TSSDGTHFMYALFNDTNVGMMTYPW 286
            |.|..          ||..::.||| |:.....|      |:..|...:..|:.:.:...:....
Human   262 DARSA----------GVATFVLQEE-FDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIH 315

  Fly   287 LSSGALFSGSGIFSGSIFPETKMV---RFPTPGTTNPEV-----------ELWAVDITNLSDIQK 337
            ::|..|             ||:..   |:|..||.||:|           |...:|:.:...||.
Human   316 VTSPML-------------ETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQP 367

  Fly   338 FNIKPPATIYGQDYYLTSAGWISDSNCQVSVVYMGRSQNYSVISLCSKE----------EDWKCL 392
            |.|     ::....|:..|||..:.....|:: :.|||....|.|.|.|          |..:.:
Human   368 FEI-----LFEGVEYIARAGWTPEGKYAWSIL-LDRSQTRLQIVLISPELFIPVEDDVMERQRLI 426

  Fly   393 E----------VHSERAPEDEWLDIFPHPVF------SSDGSSFLFLANIQES--ENYQFTHI-- 437
            |          ::.|..  |.|::|  |.:|      ..:...|:|.:..:..  ..|:.|.|
Human   427 ESVPDSVTPLIIYEETT--DIWINI--HDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILK 487

  Fly   438 --KHVMIS-------------QRRISVISHGRYEVT----KILCWDTINHKVYFMATQDKKPGQR 483
              |:...|             :..|::.| |.:||.    ..:..|.:...|||..|:| .|.:.
Human   488 ESKYKRSSGGLPAPSDFKCPIKEEIAITS-GEWEVLGRHGSNIQVDEVRRLVYFEGTKD-SPLEH 550

  Fly   484 HLYSVQDPIHDDIRKVEPQCIT--CDLGDDLWSSRYYYTNC--THFEAFITPSLGVATNYGIEFY 544
            |||.|.        .|.|..:|  .|.|       |.::.|  .|.:.||:........:.:..|
Human   551 HLYVVS--------YVNPGEVTRLTDRG-------YSHSCCISQHCDFFISKYSNQKNPHCVSLY 600

  Fly   545 -------------------ILECQGPGLP------VSGVHMQTTHSLVKILYDTRPFYTERLQKL 584
                               ||:..|| ||      :......|..:|..:||.
Human   601 KLSSPEDDPTCKTKEFWATILDSAGP-LPDYTPPEIFSFESTTGFTLYGMLYK------------ 652

  Fly   585 ALPTQRSFEVPLPHGGRAQVQLLLPPSWREELRDAAFPVIVEVNGRPGSESVSEKFKIDWGTYMS 649
                        ||.        |.|..:       :|.::.:.|.|..:.|:.:||   |....
Human   653 ------------PHD--------LQPGKK-------YPTVLFIYGGPQVQLVNNRFK---GVKYF 687

  Fly   650 SRNDV-----VYIRLDVRGS--KGQSKKTLYRH-LGGVEVLDQISVIGYLLDTIGFLDETRVGMW 706
            ..|.:     |.:.:|.|||  :|...:..::: :|.:|:.||:..:.||.....|:|..|||:.
Human   688 RLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIH 752

  Fly   707 GWGYGGYVTSMALGTQQDVFKCGIAVSPTADWL-YST-FTERILGLPAENFKGYVEADATQRARL 769
            ||.||||::.|||..:.|:|:..||.:|...|: |.| :|||.:|.|.:|.:||.......:|..
Human   753 GWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEK 817

  Fly   770 IKS--NSYFLIHGLADTTAPFVHGVQLAKSLTSANILFRYQTYADEGHDL----SGVLEHVYSSM 828
            ..|  |...|:||..|....|.|...|...|..|...:..|.|..|.|.:    ||  ||....:
Human   818 FPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESG--EHYELHL 880

  Fly   829 EQYFAECL 836
            ..|..|.|
Human   881 LHYLQENL 888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17684	NP_001015352.3	DPPIV_N	147..554	CDD:279298	99/498 (20%)
CG17684	NP_001015352.3	Abhydrolase	643..836	CDD:304388	66/208 (32%)
DPP8	NP_001307804.1	DPPIV_N	175..595	CDD:395744	105/513 (20%)
DPP8	NP_001307804.1	Peptidase_S9	686..891	CDD:395257	66/205 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810