DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17684 and ome

DIOPT Version :9

Sequence 1:	NP_001015352.3	Gene:	CG17684 / 3355066	FlyBaseID:	FBgn0263780	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_001097606.1	Gene:	ome / 44297	FlyBaseID:	FBgn0259175	Length:	1040	Species:	Drosophila melanogaster

Alignment Length:	905	Identity:	256/905 - (28%)
Similarity:	426/905 - (47%)	Gaps:	150/905 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GGGGGSWRLPP---------------DETLQVQDPKQKDHD----FDFDEG--------HNWRS- 47
            |||.|..:.||               .|::.......:|.|    ..|.||        |....
  Fly   199 GGGVGRHQHPPYYYKAAVGRRSSAKLHESMLGGGSSLEDDDGTSAGSFGEGMSRFKNLMHTKEKK 263

  Fly    48 ----IILSLLVISFVVSGIVTAIYLLGYVDE-----LLYWSGRRMILDEYLQGDLIPRRLPSSWV 103
                |||:::.....|:.:.||:..:...||     ....|...:.|::.|.|.|..:|...||.
  Fly   264 RRVRIILTVVTTVIAVALLATALVFILRTDEKDADDSDSNSNNAIDLEDVLSGQLYAKRFNGSWS 328

  Fly   104 TTQKYVFQSDDGSLAVLDTTTNLVKVLVTNHTLRQLNVRRYLC---SSDLKYVLFTHNVKKNFQK 165
            .....::: ::.|:...|..|....:|:.       :.:.|:.   |:|.:::|...|.||||:.
  Fly   329 NGNSLIYK-ENTSIMEFDAKTGERSILLE-------DAQHYVLYEKSADGEFLLLAKNYKKNFRY 385

  Fly   166 SFTAFYTIYDVTNDHHTPVKLKDTLKVQRTRLQYASW--LGNTTAIIFVVKNDIFIRQSPLVEED 228
            ||.|.|.:|::    :|...::.|::.::..|....|  :||  |::.....:::.::|.|.:|
  Fly   386 SFLAEYDLYNL----NTKEFIQLTIQNEQHYLSMVQWSPVGN--ALVINYDRNLYYKESALAQE- 443

  Fly   229 IRITSSGHENHIYNGVPDWLYQEEIFETPEAIWTSSDGTHFMYALFNDTNVGMMTYPWLSSGALF 293
            |.:||. .:..|.||:|||:|:||:|.:..|.|.:..||...:..|:|::..::.:|:...
  Fly   444 IALTSD-EQAGILNGIPDWVYEEEVFSSNVATWFNPSGTQLAFIKFDDSSTHLINFPYYGD---- 503

  Fly   294 SGSGIFSGSI---FPETKMVRFPTPGTTNPEVELWAVDITNL---SDIQKFNIKPPATIYGQDYY 352
                  :|.:   :|..:::.:|..|::||.|||..||:...   .|.......|.|.....||.
  Fly   504 ------AGDLRYQYPLHQVIAYPKAGSSNPRVELVMVDLKRAVAGGDFVTVMPVPSALNTETDYI 562

  Fly   353 LTSAGWISDSNCQVSVVYMGRSQNYS-VISLCSKEEDWKCLEVHSERAPEDEWLDIFPHPVFSSD 416
            :|...|:.|.|  |..::|.|.||.: |::.     |....:|......:..|:|::..|..:.:
  Fly   563 VTVVSWVDDDN--VLSIWMNRIQNAAYVVTF-----DGLNRKVIYSAESKTGWVDLYTAPFRNRN 620

  Fly   417 GSSFLFLANIQESENYQFTHIKHVMI--------SQRRISVISHGRYEVTKILCWDTINHKVYFM 473
            ||.   ||.:....||     |||.:        ..:.:..::.|:|.|..||.||..|..:::.
  Fly   621 GSR---LAFVLPHNNY-----KHVQLLSSTVASSEPQALEPLTEGKYVVDSILHWDGKNDIIFYT 677

  Fly   474 ATQDKKPGQRHLYSVQDPIHDDIRKVEPQCITCDL---GDDLWSSRYYYTNCTHFEAFITPSLGV 535
            |..:..|.|.|||:::     .:.|..|:|:||:|   ||         ...|:|.|....:
  Fly   678 ANTEDHPEQLHLYAIR-----ALAKQSPKCLTCNLIKSGD---------VQQTYFSATFNDN--- 725

  Fly   536 ATNYGIEFYILECQGPGLPVSGVHMQTTH-----------SLVKIL-YDTRPFYTERLQKLALPT 588
                  ...::...|||:|       |||           .:.|:| ::|......:|:.:|||:
  Fly   726 ------NHIVITSLGPGIP-------TTHIYEWKYENSQVVISKVLDWETNESLRAKLKGVALPS 777

  Fly   589 QRSFEVPLPHGGRAQVQLLLPPSWREELRDAAFPVIVEVNGRPGSESVSEKFKIDWGTYMSSRND 653
            .:...|.:..|.:|:|.|.|||: .:......:|::|:|.|.|.|.||:.|:.:|||||:||...
  Fly   778 HKILTVDIDGGFQAKVLLQLPPN-LDTSGATKYPMLVDVYGGPDSYSVTNKWMVDWGTYLSSNQS 841

  Fly   654 VVYIRLDVRGS--KGQS-KKTLYRHLGGVEVLDQISVIGYLLDTIGFLDETRVGMWGWGYGGYVT 715
            |:|.::|.|||  :|:| ...:|..||.||:.|||:|...|.....::|...||:|||.||||..
  Fly   842 VIYAKIDGRGSGLRGESLLHAIYLKLGTVEISDQINVTQKLSTLFNYIDPDHVGIWGWSYGGYAA 906

  Fly   716 SMALGTQQ-DVFKCGIAVSPTADWLY--STFTERILGLPAENFKGYVEADATQRARLIKSNSYFL 777
            :|||...: .||||..:::|..||.|  |.:|||.:|||..|..||..:..:..|..::...|.|
  Fly   907 AMALANDEAKVFKCAASIAPVTDWAYYDSIYTERYMGLPNTNELGYANSRLSTMAVKLRGKKYLL 971

  Fly   778 IHGLADTTAPFVHGVQLAKSLTSANILFRYQTYADEGHDLSGVLEHVYSSMEQYFAECLS 837
            :||..|....:...:.|||:|...:|||:..:||||.|.||.|..|:|.|::::|.||.:
  Fly   972 VHGTLDDNVHYQQAMILAKNLERQDILFKQISYADEDHGLSNVRPHLYHSLDRFFGECFA 1031

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17684	NP_001015352.3	DPPIV_N	147..554	CDD:279298	111/426 (26%)
CG17684	NP_001015352.3	Abhydrolase	643..836	CDD:304388	82/198 (41%)
ome	NP_001097606.1	DPPIV_N	367..739	CDD:279298	112/434 (26%)
		Peptidase_S9	828..1033	CDD:278741	83/204 (41%)
		FrsA	<882..1028	CDD:223999	57/145 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	136	1.000	Domainoid score	I1258
eggNOG	1	0.900	-	-		E1_COG1506
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	1	1.000	-	-		mtm8410
orthoMCL	1	0.900	-	-		OOG6_100574
Panther	1	1.100	-	-	P	PTHR11731
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X274
	9	8.820