DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17684 and Dpp10

DIOPT Version :9

Sequence 1:	NP_001015352.3	Gene:	CG17684 / 3355066	FlyBaseID:	FBgn0263780	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	XP_017454362.1	Gene:	Dpp10 / 363972	RGDID:	1306427	Length:	800	Species:	Rattus norvegicus

Alignment Length:	861	Identity:	263/861 - (30%)
Similarity:	422/861 - (49%)	Gaps:	111/861 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 PPDETLQVQDPKQKDHDFDFDEGHNWRSIILSLLVISFVVSGIVTAIYLLGYVDELLYWSGRRMI 84
            |.|:.|....|.|:          ||:.|.::|||| .||..::|...:|...|||...|..|:.
  Rat    21 PADQELGSNSPPQR----------NWKGIAIALLVI-LVVCSLITMSVILLTPDELTNSSETRLS 74

  Fly    85 LDEYLQGDLIPRRLPSSWVTTQKYVFQSDDGSLAVLDTTTNLVKVLVTNHTLRQLNVRRYLCSSD 149
            |:|.|..........:.|:.....|:::|:|.:..|:..||...:|:.|.|.......|:..|.|
  Rat    75 LEELLGKGFGLHNPEARWINDTDVVYKTDNGHVMKLNAETNATTLLLDNSTFVTFKASRHSLSPD 139

  Fly   150 LKYVLFTHNVKKNFQKSFTAFYTIYDVTNDHHT-------PVKLKDTLKVQRTRLQYASWLGNTT 207
            |||||..::||:.|..||||.|.||::    ||       |.:::|::      ||||:|.....
  Rat   140 LKYVLLAYDVKQIFHYSFTASYLIYNI----HTGEVWELNPPEVEDSV------LQYAAWGVQGQ 194

  Fly   208 AIIFVVKNDIFIRQSPLVEEDIRITSSGHENHIYNGVPDWLYQEEIFETPEAIWTSSDGTHFMYA 272
            .:|::.:|:|:. |..:....:|:||||.|..::||:.||||:||:..:..|.|.|.||....:.
  Rat   195 QLIYIFENNIYY-QPDIKSSSLRLTSSGKEGIVFNGIADWLYEEELLHSHIAHWWSPDGERLAFL 258

  Fly   273 LFNDTNVGMMTYPWLSSGALFSGSGIFSGSIFPETKMVRFPTPGTTNPEVELWAVDITNLSDIQK 337
            :.||:.|..|..|            .|:|:::|:.|...:|..|..||.|:|:.|::  ......
  Rat   259 MINDSLVPNMVIP------------RFTGALYPKAKQYPYPKAGQANPSVKLYVVNL--YGPTHT 309

  Fly   338 FNIKPPATIYGQDYYLTSAGWISDSNCQVSVVYMGRSQNYSVISLCSKEEDWKCLEVHSERAPED 402
            ..:.||.....::||:|...|:  ||.:..|.::.|.||.|::::| :.....|...:  ....|
  Rat   310 LELMPPDIFKSREYYITMVKWV--SNTRTVVRWLNRPQNISILTVC-ESTTGACSRKY--EMTSD 369

  Fly   403 EWLD-IFPHPVFSSDGSSFLFLANIQESENYQFTHIKHVMISQR--RISV--ISHGRYEVTKILC 462
            .|:. ....||||.|||.|.....:::....:|.||...::..:  :|:|  ::.|.:||.:||.
  Rat   370 TWISKQNEEPVFSRDGSKFFMTVPVKQGGRGEFHHIAMFLVQSKSEQITVRHLTSGNWEVIRILA 434

  Fly   463 WDTINHKVYFMATQDKKPGQRHLYSVQDPIHDDIRKVEPQCITCDLGDDLWSSRYYYTNCTHFEA 527
            :|....|:||::| :..|..|.|||....     ..:...||:|:...:         :||:|:|
  Rat   435 YDETTQKIYFLST-EFSPRGRQLYSASTE-----GLLSRDCISCNFRKE---------DCTYFDA 484

  Fly   528 FITPSLGVATNYGIEFYILECQGPGLPVSGVHMQTTHSLVKILYDTRPFYTERLQKLALPTQR-- 590
            ..:|.        .:.::|.|:||.:|:..:|.....|...|| :......|.:||..|..:.
  Rat   485 SFSPM--------NQHFLLFCEGPKVPMVSLHSTDNPSNYYIL-ERNSMMKETIQKKKLAKREIR 540

  Fly   591 -----SFEVPLPHGGRAQVQLLLPPSWREELRDAAFPVIVEVNGRPGSESVSEKFKIDWGTYMSS 650
                 .:|:||        ||..|..:.|:.:.|...:|.|   .||.:.|:|||.:||.:.:..
  Rat   541 ILHIDDYELPL--------QLSFPKDFLEKNQYALLLIIDE---EPGGQMVTEKFHVDWDSVLID 594

  Fly   651 RNDVVYIRLDVRGSKGQSKKTL---YRHLGGVEVLDQISVIGYLLDTIGFLDETRVGMWGWGYGG 712
            .::|:..|.|.|||..|..|.|   :|..|.||..|||:.|.|||.. .::|..|:.::|.||||
  Rat   595 TDNVIVARFDGRGSGFQGLKVLQEIHRRTGSVEAKDQIAAIKYLLKQ-PYIDSKRLSIFGKGYGG 658

  Fly   713 YVTSMALGTQQDVFKCGIAVSPTADW-LY-STFTERILGLPAENFKGYVEADATQRARLIKSNSY 775
            |:.||.|.:.:..||||..|:|.:|. || |.|:||.||:|::....|..:........:|..:.
  Rat   659 YIASMILKSDEKFFKCGTVVAPISDMKLYASAFSERYLGMPSKEESTYQASSVLHNIHGLKEENL 723

  Fly   776 FLIHGLADTTAPFVHGVQLAKSLTSANILFRYQTYADEGHDLSGVLE-HVYSSMEQYFAECLSLD 839
            .:|||.|||...|.|..:|.|.|..|.:.:..|.|.|||:.:|...: |.||::.::|::||
  Rat   724 LIIHGTADTKVHFQHSAELIKHLIKAGVNYTLQVYPDEGYHISDKSKHHFYSTILRFFSDCL--- 785

  Fly   840 PDDTKPEVDNSIVPAE 855
                |.||  |::|.|
  Rat   786 ----KEEV--SVLPQE 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17684	NP_001015352.3	DPPIV_N	147..554	CDD:279298	122/418 (29%)
CG17684	NP_001015352.3	Abhydrolase	643..836	CDD:304388	73/198 (37%)
Dpp10	XP_017454362.1	DPPIV_N	137..504	CDD:279298	122/419 (29%)
Dpp10	XP_017454362.1	Peptidase_S9	584..786	CDD:278741	76/209 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	1	1.000	-	-		FOG0000419
OrthoInspector	1	1.000	-	-		otm45634
orthoMCL	1	0.900	-	-		OOG6_100574
Panther	1	1.100	-	-	O	PTHR11731
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X274
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.780