DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17684 and CG45002

DIOPT Version :9

Sequence 1:	NP_001015352.3	Gene:	CG17684 / 3355066	FlyBaseID:	FBgn0263780	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_728041.3	Gene:	CG45002 / 32688	FlyBaseID:	FBgn0266354	Length:	1098	Species:	Drosophila melanogaster

Alignment Length:	988	Identity:	284/988 - (28%)
Similarity:	443/988 - (44%)	Gaps:	207/988 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LPPDETLQVQDPKQKDHDFDFDEGHNWRSIILSLLVISFVVSGIVTAIYLLGYVDELLYWSGRRM 83
            :|.||.|....|:::          |||.|.::||||:.|.|.|:.:|:||...||.|...||||
  Fly    36 VPKDEELVAISPERR----------NWRGIFIALLVIAAVFSLIIFSIFLLSPEDEGLRIRGRRM 90

  Fly    84 ILDEYLQGDLIPRRLPSSWVTTQKYVFQSDDGSLAVLDTTTNLVKVLVTNHTLRQLNVRRYLCSS 148
            :..:.|...|..:....:|...::.:::...|.|::|:......::|:||.|.||||...:|.:.
  Fly    91 LPSDILGRSLQWKPFNGTWSNGRELIYRDPTGGLSILNMADLTTRILMTNSTFRQLNAESFLVAP 155

  Fly   149 DLKYVLFTHNVKKNFQKSFTAFYTIYDVTNDHHTPVKLKDTLKVQRTRLQYASW--------LG- 204
            |.||||...:......:     :.:|:|...:..|:...:.: .:..|||:..|        ||
  Fly   156 DQKYVLLQSDSNAEGSR-----HHVYEVQTANTFPLGPTENI-AEAPRLQHVVWAPANPPPPLGA 214

  Fly   205 ---------------NTT----------------------------------------------A 208
                           :||                                              |
  Fly   215 PPPSGASGASGASGASTTTMAPLPSGSIILNSLAGAANGPASAGASGSSAPNPNGKAGGYNLNQA 279

  Fly   209 IIFVVKNDIFIRQSPLVEEDI--RITSSG-------HENHIYNGVPDWLYQE--EIFETPEAIWT 262
            |.||..|||:.:  |.|:.::  |||.:|       ....::||||||:|:.  |:.....::..
  Fly   280 IAFVHHNDIYYK--PKVQGELVCRITQTGSGSLEGESTGVVFNGVPDWMYENVPELESRRSSMEF 342

  Fly   263 SSDGTHFMYALFNDTNVGMMTYPWLSSGALFSGSGIFSGSIFPETKMVRFPTPGTTNPEVELWAV 327
            |.||....:..:||:.|....|.|:       |..|    .:|.....|:|..|:.||.|   .|
  Fly   343 SPDGLFLAFLSYNDSEVNEYKYTWM-------GDDI----KYPAVMSQRYPKTGSRNPNV---TV 393

  Fly   328 DITNLSDIQKF---NIKPPATIYGQDYYLTSAGWISDSNCQVSVVYMGRSQNYSVISLCSKEEDW 389
            ::.|||.|:..   .||.|:.: ....|:....|.|.::..|:|.  .|.|..:...|| :...:
  Fly   394 NVVNLSVIKYIFPTQIKLPSEL-SNGSYVGGLTWASSTDLSVTVT--NREQTKATTVLC-RAPHF 454

  Fly   390 KCLEVHSERAPEDEWLDIFPHPVFS---------------------------------------S 415
            .|..||:|....|.|:.....|:||                                       |
  Fly   455 HCQAVHTEVTINDGWVLPSERPIFSVRNQGHNRLGKMVQNAEEIQAESQNVNVTDGQTHTTHEIS 519

  Fly   416 DGSSFLFLANIQESENYQFTHIKHVMISQRRISVISHGRYEVTKILCWDTINHKVYFMATQDKKP 480
            :|...|....:::.|:..:.|:..:....||...::.||:|||:|:.||..:..|||||..:|:|
  Fly   520 NGGYLLKRLPVRDGEHGHYRHVVFISSLDRRPVPLTMGRFEVTEIVGWDEPHEIVYFMAAPEKRP 584

  Fly   481 GQRHLY------SVQDPIHDDIRKVEPQCITCDLGD--------------DLWS---SRYYYTNC 522
            |:||||      :|.:.....|....|.|:|||..:              |.|.   :|....:|
  Fly   585 GERHLYKISLKLNVTESNRTYITSTSPTCLTCDNTESTYRLHRARISQRGDRWEDIVARLEPDDC 649

  Fly   523 TH-------FEAFITPSLGVATNYGIEFYILECQGPGLPVSGVHMQTTHSLVKI-LYDTRPFYTE 579
            .:       |..       |..:....:|:.||.||..|  .|::..|.|..|| :.:.......
  Fly   650 LYDIPKNCLFNR-------VQFSQDYSYYVQECLGPEAP--SVYLVETASNDKIYVLNAGDVLRH 705

  Fly   580 RLQKLALPTQRSFEVPLPHGGRAQVQLLLPPSWREELRDAAFPVIVEVNGRPGSESVSEKFKIDW 644
            ||.:||:|..|:|.|.:.||..|||:|.|||..||| .|.|||:::.|:..|||:.|:|:|.:||
  Fly   706 RLSQLAIPQSRTFSVEIRHGFHAQVRLFLPPGMREE-EDVAFPLVLHVDASPGSQLVTERFHVDW 769

  Fly   645 GTYMSSRNDVVYIRLDVRGS--KGQSKKT-LYRHLGGVEVLDQISVIGYLLDTIGFLDETRVGMW 706
            ..|::|:...:..::|.|||  :|:..:| ::..||.|||.||:.|:.||.|.:.|:|..|:..:
  Fly   770 NWYLASQRSFIVAQIDGRGSGFQGELLRTQVHGKLGTVEVEDQLGVLTYLRDNLKFIDPLRICAF 834

  Fly   707 GWGYGGYVTSMAL-GTQQDVFKCGIAVSPTAD--WLYSTFTERILGLPAENFKGYVEADATQRAR 768
            |||||||.:||.| ...|.|.:|.:|::|..:  :.||.||||.:.|..:..:...|||.|.:|.
  Fly   835 GWGYGGYASSMMLIDDSQQVLQCAVAINPIVNFGFHYSFFTERYIPLKGDYLRALQEADLTMKAG 899

  Fly   769 LIKSNSYFLIHGLADTTAPFVHGVQLAKSLTSANILFRYQTYADEGHDLSGVLEHVYSSMEQYFA 833
            .||..:..|:||.|||.....|.:.|.::|....:.||:|.|.||.|.::..|.|||.:||.||.
  Fly   900 NIKGRNLMLMHGTADTLVHQEHTLMLVRALVEQQVKFRHQVYPDEDHAIARSLSHVYKTMEWYFD 964

  Fly   834 ECLS-LDPDDTKP 845
            ||.. :|.::..|
  Fly   965 ECFGPVDDNEWDP 977

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17684	NP_001015352.3	DPPIV_N	147..554	CDD:279298	125/559 (22%)
CG17684	NP_001015352.3	Abhydrolase	643..836	CDD:304388	78/198 (39%)
CG45002	NP_728041.3	DPPIV_N	278..681	CDD:279298	109/429 (25%)
		DAP2	<664..968	CDD:224423	121/306 (40%)
		Abhydrolase	765..969	CDD:304388	80/203 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	157	1.000	Domainoid score	I2534
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	256	1.000	Inparanoid score	I1947
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D269253at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8410
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11731
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.070