DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17684 and Dpp9

DIOPT Version :9

Sequence 1:	NP_001015352.3	Gene:	CG17684 / 3355066	FlyBaseID:	FBgn0263780	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	XP_217309.6	Gene:	Dpp9 / 301130	RGDID:	1588575	Length:	921	Species:	Rattus norvegicus

Alignment Length:	739	Identity:	169/739 - (22%)
Similarity:	283/739 - (38%)	Gaps:	191/739 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 FVVKNDIFIRQSPLVEEDIRIT------SSGHENHIYNGVPDWLYQEEI------FETPEAIWTS 263
            |:..||:::......||. |:|      :|..:|....||..::.|||.      :..|.|.|..
  Rat   261 FINNNDLWVANIETGEER-RLTFCHQGSASVLDNPKSAGVATFVIQEEFDRFTGCWWCPTASWEG 324

  Fly   264 SDGTHFMYALFNDTNVGMMTYPWLSSGALFSGSGIFSGSIFPETKMVRFPTPGTTNPEVELWAVD 328
            |.|...:..|:.:.:...:....:.|.||..          .:|...|:|..|:.||::.|...:
  Rat   325 SGGLKTLRILYEEVDESEVEVIHVPSPALEE----------RKTDSYRYPRTGSKNPKIALKLAE 379

  Fly   329 ITN------LSDIQKFNIKPPATIYGQDYYLTSAGWISDSNCQVSVVYMGRSQNYSVISL----- 382
            :..      :|..:|..::|.::::.:..|:..|||..|.. ....:::.|.|....:.|
  Rat   380 LQTDHQGKIVSSCEKELVQPFSSLFPKVEYIARAGWTRDGR-YAWAMFLDRPQQRLQLVLLPPAL 443

  Fly   383 ----CSKEEDWKCLEVHSERA-PE------------DEWL---DIFPHPVFSSDG-SSFLFL-AN 425
                ...|..|:    .:.|| |:            :.|:   ||| ||...::| ..|.|| ||
  Rat   444 FIPTLESEAQWQ----EAARAIPKNVQPFIIYEEVTNVWINVHDIF-HPFPQAEGQQDFCFLRAN 503

  Fly   426 IQESENYQFTHIKHVMIS-----------------------QRRISVISHGRYEV-----TKILC 462
            ..::   .|.|:..|.:.                       :..:::.| |.:||     :||
  Rat   504 ECKT---GFCHLYRVTVDLKTNDYDWTEPLSPAEDEFKCPIKEEVALTS-GEWEVLSRHGSKI-- 562

  Fly   463 WDTINHK---VYFMATQDKKPGQRHLYSVQ-DPIHDDIRKVEPQ-CITCDLGDDLWSSRYYYTNC 522
            |  :|.:   |||..|:| .|.:.|||.|. :...:.:|...|. ..:|.:..
  Rat   563 W--VNEQTKLVYFQGTKD-TPLEHHLYVVSYESAGEIVRLTTPGFSHSCSMSQ------------ 612

  Fly   523 THFEAFITPSLGVATNYGIEFYILECQGPGLPVSGVHMQTTHSLVKILYDTRPFYTERLQKLALP 587
             :|:.|::....|:|...:..|.|  .||  ....:|.|..            |:...::..:.|
  Rat   613 -NFDMFVSHYSSVSTPPCVHVYKL--SGP--DDDPLHKQPR------------FWASMMEAASCP 660

  Fly   588 TQRSFEVP---LPHGGRAQVQL--------LLPPSWREELRDAAFPVIVEVNGRPGSESVSEKFK 641
            ..   .||   .....||.|||        .|.|..:.       |.::.|.|.|..:.|:..||
  Rat   661 PD---YVPPEIFHFHTRADVQLYGMIYKPHTLQPGRKH-------PTVLFVYGGPQVQLVNNSFK 715

  Fly   642 IDWGTYMSSRNDVVYIRLDVRGSKGQS----------------KKTLYRHLGGVEVLDQISVIGY 690
                       .:.|:||:...|.|.:                :..|...:|.||:.||:..:.|
  Rat   716 -----------GIKYLRLNTLASLGYAVVVIDGRGSCQRGLHFEGALKNQMGQVEIEDQVEGLQY 769

  Fly   691 LLDTIGFLDETRVGMWGWGYGGYVTSMALGTQQDVFKCGIAVSPTADWL-YST-FTERILGLPAE 753
            :.:..||:|.:||.:.||.|||:::.|.|..:..|||..||.:|...|: |.| :|||.:.:|..
  Rat   770 VAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPEN 834

  Fly   754 NFKGYVEADATQRARLI--KSNSYFLIHGLADTTAPFVHGVQLAKSLTSANILFRYQTYADEGHD 816
            |.:||...........:  :.|...::||..|....|.|...|...|..|...::.|.|.:|.|.
  Rat   835 NQQGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHS 899

  Fly   817 L----SGVLEHVYSSMEQYFAECL 836
            :    ||  ||...::..:..|.|
  Rat   900 IRCRESG--EHYEVTLLHFLQEHL 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17684	NP_001015352.3	DPPIV_N	147..554	CDD:279298	90/420 (21%)
CG17684	NP_001015352.3	Abhydrolase	643..836	CDD:304388	58/216 (27%)
Dpp9	XP_217309.6	DPPIV_N	204..628	CDD:279298	86/405 (21%)
		FrsA	671..921	CDD:223999	72/269 (27%)
		Peptidase_S9	720..921	CDD:278741	57/202 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1506
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810